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Soft lentinan capsule and its prepn

A technology of lentinan and lentinan, which is applied in the field of medicine, can solve the problems of inconvenient taking, unstable quality, and low bioavailability, and achieve the effects of convenient taking, high bioavailability, and simple production process

Inactive Publication Date: 2007-01-03
ZHUHAI EBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its main disadvantages are unstable quality, inconvenient taking, and low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Component Quantity (g / grain)

[0032] Lentinan 0.01

[0033] Salad oil 0.20

[0034] Beeswax 0.08

[0035] Gelatin 0.07

[0036] Glycerin 0.024

[0037] Benzyl alcohol 0.0006

[0038] Sorbic acid 0.00005

[0039] It is 384.65g based on 1000 grains.

[0040] The operation method of the above-mentioned embodiment is as follows: take gelatin and place it in a chemical glue tank, add distilled water and glycerin, heat to 85°C and stir, after the gelatin is completely dissolved, add preservatives and antioxidants, stir evenly, and after degassing, place in Keep warm at 65°C to obtain the gel solution of the soft capsule capsule material; take the suspending agent and diluent and heat and dissolve in a water bath at 65°C, then add the raw material of lentinan polysaccharide passed through a 80-mesh sieve, stir and mix evenly, cool to room temperature, and pass through the colloid Grind and polish twice to remove the air bubbles therein and further mix uniformly to form...

Embodiment 2

[0042] Component Quantity (g / grain)

[0043] Lentinan 0.01

[0044] Salad oil 0.15

[0045] Beeswax 0.08

[0046] Gelatin 0.07

[0047] Glycerin 0.024

[0048] Citric acid 0.0004

[0049] Sorbic acid 0.00005

[0050] It is 334.45g based on 1000 grains. Operation method is the same as embodiment 1.

Embodiment 3

[0052] Component Quantity (g / grain)

[0053] Lentinan 0.01

[0054] Salad oil 0.25

[0055] Hydroxyethyl methylcellulose 0.03

[0056]Gelatin 0.07

[0057] Glycerin 0.024

[0058] Citric acid 0.0006

[0059] Sorbic acid 0.00006

[0060] It is 384.66g based on 1000 grains. Operation method is the same as embodiment 1.

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PUM

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Abstract

The present invention discloses one kind of soft lentinan capsule and its preparation process, and the soft lentinan capsule is prepared through suspending lentinan in diluent to form stable suspension and filling the suspension into soft capsule shell. Of each 1000 capsules in 334.45-824.07 g, there are lentinan 10-50 g, diluent 100-400 g, gelatin 50-180 g and glycerin 14.1-64.5 g. The inclusion contains lentinan, diluent and suspending agent; and the capsule shell contains gelatin, glycerin, water, preservative and antioxidant. The soft lentinan capsule has the functions of benefiting Qi, invigorating spleen, tonifying deficiency and strengthening body's resistance, and may be used in treating chronic hepatitis B and as the assisting medicine for radiotherapy and chemotherapy treating tumor in digestive tract. The present invention has the advantages of stable quality, convenient taking and high bioavailability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a lentinan soft capsule used as an adjuvant drug for radiotherapy and chemotherapy for chronic persistent hepatitis B and digestive tract tumors and a preparation method thereof. Background technique [0002] Lentinus lentinus polysaccharide is a peptidoglycan extracted from the mycelium of lentinus edodes cultured by submerged fermentation and the fermentation broth. The polysaccharide part mainly contains mannitol glucose and a small amount of galactose. The peptide chain is mainly composed of aspartic acid, serine, lysine and glutamic acid, and contains a small amount of other amino acids. [0003] Studies have shown that: Lentinus polysaccharides can regulate chronic hepatitis T cell subsets, thereby improving the body's cellular immune function and having the function of an interferon inducer, thereby preventing the replication and proliferation of viruses in liver cells, and...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K9/48A61P1/16A61P35/00
Inventor 孙登雄韦梦星
Owner ZHUHAI EBANG PHARMA
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