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Method for preparing CaO-P2O5-MgO glass reinforced porous beta-tricalcium phosphate bioceramics

A cao-p2o5-na2o-mgo, glass-reinforced technology, applied in the direction of ceramic products, applications, home appliances, etc., can solve the problems that are not enough to meet clinical applications

Inactive Publication Date: 2006-09-13
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the contradiction between high porosity and low strength has always restricted the development and application of this material. The compressive strength of calcium phosphate porous materials reported so far is 0.3-3.3 MPa, which is not enough to meet the requirements of clinical application.

Method used

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  • Method for preparing CaO-P2O5-MgO glass reinforced porous beta-tricalcium phosphate bioceramics
  • Method for preparing CaO-P2O5-MgO glass reinforced porous beta-tricalcium phosphate bioceramics
  • Method for preparing CaO-P2O5-MgO glass reinforced porous beta-tricalcium phosphate bioceramics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: CaO-P 2 o 5 -Na 2 O-MgO bioglass

[0021] Take NH 4 h 2 PO 4 , Ca(OH) 2 、Na 2 CO 3 , (MgCO 3 ) 4 Mg(OH) 2 ·5H 2 O is the raw material, according to the P in the raw material 2 o 5 :CaO:Na 2 The mass percentage of O:MgO is 62:14.7:18:5.30, the total mass is 100 grams, and 47.12 grams of NH 4 h 2 PO 4 , 19.45 g Ca(OH) 2 , 30.19 g Na2 CO 3 and 63.69 g (MgCO 3 ) 4 Mg(OH) 2 ·5H 2 O. Grind the said raw material evenly, pour it into a beaker, slowly add deionized water, and keep stirring until no bubbles come out. The mixture is dried in an oven at a constant temperature of 80°C, and then calcined and melted. In the temperature range from ℃ to 910℃, the heating rate is 3.5℃ / minute, and the temperature is raised to 910℃ for 1 hour. The molten glass is naturally cooled, ground and sieved with the furnace temperature. The ground glass powder is heat treated at 700°C for half an hour, cooled to room temperature, then heated to 740°C for 1 hour...

Embodiment 2

[0022] Example 2: CaO-P 2 o 5 -Na 2 O-MgO bioglass

[0023] to (NH 4 ) 2 HPO 4 , CaCO 3 、Na 2 CO 3 , MgCO 3 as the raw material, according to the P in the raw material 2 o 5 :CaO:Na 2 The mass percentage of O:MgO is 41.4:9.80:12:3.50, the total mass is 50 grams, and 26.98 grams (NH 4 ) 2 HPO 4 , 13.06 g CaCO 3 , 15.40 g Na 2 CO 3 and 5.46 g MgCO 3 . Grind the said raw material evenly, pour it into a beaker, slowly add deionized water, and keep stirring until no bubbles come out. The mixture is dried in an oven at a constant temperature of 80°C, and then calcined and melted. ℃~980℃ temperature range, the heating rate is 3.5℃ / min, and the temperature is raised to 980℃ for 2 hours. The molten glass is naturally cooled with the furnace, ground and sieved. The ground glass fine powder is heat treated at 720°C for half an hour, cooled to room temperature, then heated to 750°C for 1 hour, then heat treated at 800°C for 2 hours, and naturally cooled with the furn...

Embodiment 3

[0024] Example 3: Glass Reinforced Tricalcium Phosphate Porous Ceramics

[0025] Raw materials: medical grade calcium carbonate (CaCO 3 ) and calcium hydrogen phosphate dihydrate (CaHPO 4 2H 2 O) is a raw material, and it is 1.5 to accurately weigh 171.1 grams of CaHPO by Ca / P mol ratio 4 2H 2 O and 50.0 g CaCO 3 , Pour the weighed material into a ball mill jar, add deionized water and zirconia balls. According to the ratio of material: grinding ball: water, the mass ratio is 1:3:2.2, the mixture is high-speed ball milled for 16 hours, dried at a constant temperature of 85°C in an oven, and calcined at 830°C after drying to obtain an average particle size of 380nm. Beta-calcium phosphate powder.

[0026] Process: β-tricalcium phosphate and the bioglass prepared in Example 1 are 80:20 by mass percentage, weigh the mixed powder with a total weight of 50 grams, measure 33 milliliters of deionized water, and add molar concentration to the deionized water 4 milliliters of am...

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Abstract

A CaO-P2O5-Na2O-MgO glass reinforced porous beta-tricalcium phosphate bioceramic is prepared through proportionally mixing P2O5, CaO, Na2O and MgO, smelting, heat treating for educing crystals to obtain bioglass, proportionally adding it to beta-calcium triphosphate powder, and porous foam immersion.

Description

technical field [0001] The present invention relates to a kind of CaO-P 2 o 5 -Na 2 The invention discloses a preparation method of O-MgO glass reinforced porous β-tricalcium phosphate bioceramic, which belongs to the technical field of bioceramic preparation. Background technique [0002] Porous biomaterials have irreplaceable functions in tissue engineering. Calcium phosphate-based materials are considered to be the best bone repair materials for bionic bone, scaffolds and carriers because of their good biocompatibility and bioactivity. Widely used in orthopedic surgery, plastic surgery and dentistry. β-tricalcium phosphate is an important binary compound in the calcium-phosphorus system. It is generally considered to be an absorbable bioactive ceramic material. When it is implanted in the human body, it can be degraded in the body, and the degraded Ca and P enter the living body. The circulatory system forms new bone, which has good biocompatibility and osteoinductive...

Claims

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Application Information

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IPC IPC(8): C04B35/82C04B35/447C04B38/00
Inventor 蔡舒于显著许国华肖张莹张喆
Owner TIANJIN UNIV
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