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Preparation method of biologically active nanometer composite layer on medical-use metal surface

A bioactive and nanocomposite technology is applied in the field of preparing bioactive composite layers with nanostructures, and achieves the effects of simple procedure, strong operability and short time period.

Inactive Publication Date: 2006-05-10
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the surface modification of medical metals is carried out by chemical methods or electrochemical methods. The prepared metal surface only has a micron-scale pore structure, and the nanostructure has not been successfully applied to the surface modification of medical metals in a real sense.

Method used

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  • Preparation method of biologically active nanometer composite layer on medical-use metal surface

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Experimental program
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preparation example Construction

[0023] Such as figure 1 Shown, the present invention provides a kind of medical metal surface bioactive nanocomposite layer preparation method, and it comprises the steps:

[0024] Pretreatment step, put the medical pure titanium or titanium alloy substrate into the diluted acid solution for erosion treatment;

[0025] In the anodic oxidation step, the pretreated titanium or titanium alloy substrate is used as the anode, placed in a polytetrafluoroethylene beaker containing an electrolyte solution, and the stainless steel or platinum sheet is used as the cathode, and anodized for 0.5 to 6 hours to form a dense Titanium dioxide nanotube structure film;

[0026] Activation treatment step, after the anodic oxidation is completed, wash the titanium or titanium alloy substrate with water, and put it into an alkaline solution at 40-80°C for activation treatment for 0.5-3 hours;

[0027] Heat treatment step, the treated titanium or titanium alloy substrate is placed in a temperatur...

experiment example 1

[0037]Put the medical pure titanium TA2 matrix into 3% diluted hydrofluoric acid solution for erosion for 60 seconds, remove the dirt and oxides on the surface, rinse and dry with deionized water; put the pretreated titanium matrix As an anode, put it into a polytetrafluoroethylene beaker containing 0.4% hydrofluoric acid electrolyte, and stainless steel as a cathode, perform anodic oxidation at a DC voltage of 20V and 15°C for 0.5 hours; put the oxidized titanium substrate into a 60 ℃ for 1 hour in a 5mol / L sodium hydroxide solution, rinsed with deionized water, and dried; then put the titanium substrate into a temperature-controlled box-type resistance furnace and raise the temperature to 500°C with a heating rate of 5°C / min, and kept at 500°C for 2 hours, and took it out after cooling to room temperature. After immersing the treated titanium substrate in a pre-prepared simulated body fluid at 36.5°C for 7 days, it was taken out for cleaning and drying. Wherein, each ion c...

experiment example 2

[0039] Put the medical titanium alloy substrate into a mixture containing 2% hydrofluoric acid and 15% nitric acid for 60 seconds to remove dirt and oxides on the surface, rinse and dry with deionized water; The treated titanium alloy substrate is used as an anode, put into a polytetrafluoroethylene beaker containing 0.4% hydrofluoric acid electrolyte, stainless steel is used as a cathode, and anodic oxidation is carried out at a DC voltage of 20V and 25°C for 0.5 hours; the oxidized Put the titanium alloy substrate into a 10mol / L sodium hydroxide solution at 60°C for 30 minutes of activation treatment, rinse with deionized water, and dry; then put the titanium alloy substrate into a temperature-controlled box-type resistance furnace and raise the temperature to 600 °C, the heating rate is 10 °C / min, and it is kept at 600 °C for 1 hour, and it is taken out after cooling to room temperature. After immersing the treated titanium alloy substrate in the pre-prepared simulated body...

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Abstract

This invention relates to a biological active nanometer compound layer making method for the medical metal surface, which includes the following steps: putting the medical metal titanium and its alloy radix into the diluent acid liquid to do corrad pretreatment; using the pretreated titanium and its alloy radix as the anode to do anode oxidation to create the compact titanium dioxide nanometer tube film on the surface of the metal; putting them into the alkali lye to do activation treatment, then doing heat treatment with them under 450íµí½650íµ for 0.5í½3 hours; Then putting them into the simulate liquid to produce hydroxyl apatite. The charater of this invention is that it provides a method that combines the anode oxidation and alkali heat treatment, and this invention impoves the biological compatibility of the medical metal greatly.

Description

【Technical field】 [0001] The invention relates to a method for preparing a bioactive nanocomposite layer on the surface of a medical material, in particular to a method for preparing a bioactive composite layer with a nanostructure in a body fluid environment by combining an anodic oxidation method and a chemical method. 【Background technique】 [0002] Titanium and titanium alloys are biomaterials commonly used in human hard tissues in the medical field due to their excellent mechanical strength, low density, low elastic modulus, and good corrosion resistance in physiological environments. However, if titanium and titanium alloys are in the environment of the human body for a long time, there will be problems of low biological activity and dissolution of metal ions. In order to solve the above problems, it is necessary to control and improve the surface properties of metals, and improve the biocompatibility and corrosion resistance of metal implant materials through surface ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C28/04A61L27/32
Inventor 王臻李荣先
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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