Rhodiola root powdery injection and its preparation
A Rhodiola rosea powder injection technology, which is applied in the field of preparation of the large-plant Rhodiola rosea powder injection, can solve the problems of high stability, high bioavailability, restrictions on the application of large-plant Rhodiola rosea, and long medication cycle. Achieve significant anti-myocardial ischemia, significant anti-cerebral ischemia effects, and rapid onset of effect
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Embodiment 1
[0017] (1) Get 1000g of large rhodiola medicinal material, slice it, use 12 times the amount of 45% ethanol to reflux extract 3 times each time, each time for 1 hour, combine the extracts, filter, and the filtrate reclaims ethanol under reduced pressure and concentrates to relative For a concentrated solution with a density of 1.05 (60°C), add 3 times the amount of water, stir evenly, refrigerate for 72 hours, filter, and concentrate the filtrate under reduced pressure to a concentrated solution with a relative density of 1.08 (60°C), add ethanol to make the The amount reaches 80%, stir well, adjust the pH value to 8.0 with 20% sodium hydroxide solution, refrigerate for 48 hours, filter, and the filtrate recovers ethanol under reduced pressure and concentrates to a concentrated solution with a relative density of 1.12 (60°C) to obtain extract, spare;
[0018] (2) Get the above-mentioned extract, flow through the macroporous adsorption resin chromatography column, first elute w...
Embodiment 2
[0021] (1) Get 1000g of large rhodiola medicinal material, slice it, and extract 3 times with 10 times the amount of 65% ethanol at a time, each time for 1 hour, combine the extracts, filter, and the filtrate reclaims ethanol under reduced pressure and concentrates it to a relatively high temperature. For a concentrated solution with a density of 1.08 (60°C), add 4 times the amount of water, stir evenly, refrigerate for 66 hours, filter, and concentrate the filtrate under reduced pressure to a concentrated solution with a relative density of 1.06 (60°C), add ethanol to make the The amount reaches 85%, stir well, adjust the pH value to 8.5 with 30% sodium hydroxide solution, refrigerate for 38 hours, filter, and the filtrate recovers ethanol under reduced pressure and concentrates to a concentrated solution with a relative density of 1.13 (60°C) to obtain extract, spare;
[0022] (2) Get the above-mentioned extract, extract it with an equal volume of n-butanol each time, extrac...
Embodiment 3
[0025] (1) Get 1000g of large rhodiola medicinal material, slice it, and extract twice with 12 times of 60% ethanol backflow, each time for 1.5 hours, combine the extracts, filter, and the filtrate reclaims ethanol under reduced pressure and concentrates it to a relatively high temperature. For a concentrated solution with a density of 1.06 (60°C), add 5 times the amount of water, stir evenly, refrigerate for 56 hours, filter, and concentrate the filtrate under reduced pressure to a concentrated solution with a relative density of 1.07 (60°C), add ethanol to make the The amount reaches 85%, stir well, adjust the pH value to 8.5 with 30% sodium hydroxide solution, refrigerate for 48 hours, filter, and the filtrate recovers ethanol under reduced pressure and concentrates to a concentrated solution with a relative density of 1.18 (60°C) to obtain extract, spare;
[0026] (2) Take the above extract, after vacuum drying, grind into fine powder, dissolve with 250ml of ethanol, add 1...
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