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Hollow fiber medicine carrier and its preparing method and use

A hollow, drug-based technology, which is applied in drug delivery, drug formulations, drug devices, etc., can solve problems such as compression resistance, poor flexural performance, poor plasticity, and brittle quality, so as to improve utilization rate, improve treatment effect, reduce effect of dosage

Inactive Publication Date: 2006-11-29
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, this system still has some shortcomings when repairing bone defects, such as poor plasticity, brittle quality, poor compression and fracture resistance, and cannot be used to repair load-bearing bone defects.
[0005] In summary, although there are many sustained-release drug carrier materials that can act as bone defect repair, and some drug release carrier systems have been commercially developed and applied, they all have shortcomings to varying degrees. It is a drug capsule, capsule material or implantable particle. The release process of the drug and the dose of the drug released are not only affected by the molecular weight, molecular size, water solubility and compatibility of the carrier material of the drug, but also by the carrier. The influence of material composition, structure, molecular weight, acid value, degradation rate, etc.

Method used

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  • Hollow fiber medicine carrier and its preparing method and use
  • Hollow fiber medicine carrier and its preparing method and use
  • Hollow fiber medicine carrier and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: see figure 1

[0031] The hollow bio-inorganic fiber drug carrier and filling material for root canal filling were prepared by precursor wire drawing method and drug vacuum adsorption method. The specific process is as follows:

[0032] 1. Sodium alginate (Na-Alg) and sodium pyrophosphate (Na-Alg) with a mass ratio of 2.3:1 4 P 2 o 7 ) was dissolved in hot water and stirred to completely dissolve into a sol, and the pH value of the sol was adjusted to 7 with acetic acid, and then stood in a constant temperature tank at 75°C for 1.5 hours to obtain a uniform phosphorus-containing sol without bubbles. (2) Phosphorus-containing sol in 0.4mol / L CaCl 2 drawing in solution, such as figure 1 , and then washed with water and dried to obtain dry precursor fibers. (3) The precursor fiber is treated at high temperature in air, the heat treatment temperature is 900° C., and the heat treatment time is 0.5 hour. A hollow bioinorganic fiber is obtained.

[0033]...

Embodiment 2

[0035] The inorganic hollow fiber is prepared by electrophoretic deposition method, and after filling the hollow fiber with medicine, the bone filling material is prepared with bio-inorganic bone cement, which is used for bone tuberculosis and bone defect repair. The specific process is as follows:

[0036] 1. Select the hydroxyapatite suspension as the electrophoretic deposition medium, alcohol as the suspension, the solid content of the suspension: 25g / L, and add 0.5% magnetic glass.

[0037] 2. Select carbon fiber as the precursor, and prepare bioactive calcium phosphate coating on its surface by electrophoretic deposition. Electrophoretic deposition pulse voltage: 30V, pulse current: 50mA, deposition time: 30s

[0038] 3. Treat the precursor fibers at high temperature in the air, the heat treatment temperature: 1000°C, and the heat treatment time: 0.5 hours.

[0039] 4. Add rifampicin to the mixer cup and dissolve it in a water bath at 50°C; use rifampicin vacuum adsorpt...

Embodiment 3

[0041] The biodegradable polymer hollow fiber is prepared by melt stretching method, and after the drug is filled in the hollow fiber, the bone filling material is prepared with bio-inorganic bone cement for tumor treatment. The specific process is as follows:

[0042] 1. Melt the degradable polylactic acid at a temperature of 115° C. using a melt rheometer. The melt is passed through a hollow blowing spinneret to form a hollow fiber, and the required hollow degradable polymer fiber is obtained through drawing and stretching.

[0043] 2. Add doxorubicin into the mixer cup to dissolve, and use vacuum adsorption method in the prepared hollow fiber, then take out the composite carrier, freeze-dry several times at low temperature to realize the drug deposition in the hollow fiber; use calcium phosphate bone cement to The hollow fiber carrier is modulated into a drug-loaded filling material to obtain the required hollow fiber drug carrier for tumor treatment.

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Abstract

The medicine carrying hollow fiber is medicine controlled releasing material prepared with inorganic bioactive hollow fiber or degradable polymer fiber as carrier and through deposition or adsorption of medicine on the hollow fiber carrier. The inorganic bioactive hollow fiber is prepared with hollow fiber precursor and through wire drawing process or electrophoresis deposition. The degradable polymer fiber may be prepared through composite painting process or smelting and stretching process. The medicine is deposited or adsorbed onto the hollow fiber substrate through perfusion, soaking, vacuum adsorption and drying, or low temperature freeze drying. The present invention has controllable medicine carrying amount and simple operation, and the medicine carrying hollow fiber may be implanted easily and have its medicine control released. In addition, the medicine carrying hollow fiber may be also used as implanted material or stuffing material.

Description

technical field [0001] The invention relates to a hollow fiber drug carrier and its preparation method and application Background technique [0002] The treatment of acute and chronic diseases can be effectively treated through the release of drugs. At present, various drug release systems such as tablets, injections, creams, ointments, and aerosols have been formed. Due to the instability, toxicity, small therapeutic range and solubility problems of some drugs, according to the general administration method, the drug concentration in the human body can only be maintained for a short period of time. The drug concentration fluctuates greatly, sometimes exceeding the patient's maximum tolerated dose of the drug, and sometimes lower than the effective dose, which will not only fail to achieve the desired curative effect, but may also cause side effects; frequent small doses of medication can regulate blood The drug concentration can avoid the above phenomenon, but it is often ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/02A61K9/00A61M31/00
Inventor 李世普张宏泉阎玉华万涛戴红莲
Owner WUHAN UNIV OF TECH
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