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A fiber bundle/polypeptide hydrogel containing double drugs for promoting wound healing and preparation method thereof

A technology for healing double drugs and wound healing, which is applied in the directions of medical preparations containing active ingredients, medical preparations without active ingredients, and pharmaceutical formulas, which can solve the problems of single drug release form and uneven drug loading, and achieve biological Good compatibility, convenient and fast production process, and the effect of promoting wound healing

Active Publication Date: 2021-08-03
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of uneven drug loading and single drug release form caused by the physical embedding of hydrogel drugs used for wound healing in the prior art, and combine polymer fiber bundles with polypeptide hydrogels , using microfluidic textile technology to prepare sodium alginate fiber bundles, and quickly self-assemble peptides around the fiber bundles to provide a fiber bundle / polypeptide composite hydrogel system that can contain two drugs that promote wound healing. The rapid release of anti-inflammatory drugs and the slow release of wound repair drugs, while providing suitable humidity and ventilation environment for the wound, can promote chronic wound healing

Method used

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  • A fiber bundle/polypeptide hydrogel containing double drugs for promoting wound healing and preparation method thereof
  • A fiber bundle/polypeptide hydrogel containing double drugs for promoting wound healing and preparation method thereof
  • A fiber bundle/polypeptide hydrogel containing double drugs for promoting wound healing and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0071] A sodium alginate fiber bundle / polypeptide hydrogel containing double drugs to promote wound healing is prepared by the following preparation method, including the following steps:

[0072] Step (1), 1 μg of recombinant bovine basic fibroblast growth factor (purchased from Shanghai Sangon Bioengineering Co., Ltd., C600062-0010) was dissolved in 10mL of 3wt% sodium alginate aqueous solution to form a mesophase solution; 3g Dissolve calcium chloride powder in 100mL isopropanol, stir until completely dissolved, and prepare 3% w / v calcium chloride isopropanol solution as the external phase solution; draw 1mL intermediate phase solution and 100mL external phase solution into the syringe Injected into the inner and outer phases of the microfluidic chip respectively, the flow rate of the inner phase is 50 μL / min, and the flow rate of the outer phase is 500 μL / min, to prepare sodium alginate fiber bundles loaded with recombinant bovine basic fibroblast growth factor; Collect so...

Embodiment 2

[0076] A sodium alginate fiber bundle / polypeptide hydrogel containing double drugs to promote wound healing is prepared by the following preparation method, including the following steps:

[0077] Step (1), dissolving 1 μg of recombinant bovine basic fibroblast growth factor in 10mL of 3wt% sodium alginate aqueous solution to form a mesophase solution; dissolving 3g of calcium chloride powder in 100mL of isopropanol and stirring until completely dissolved , prepared into 3% w / v calcium chloride isopropanol solution as the external phase solution; pump 1mL of the intermediate phase solution and 100mL of the external phase solution into the syringe, inject them into the internal and external phases of the microfluidic chip, and the internal phase The flow rate of the external phase is 50 μL / min, and the flow rate of the external phase is 500 μL / min to prepare sodium alginate fiber bundles loaded with recombinant bovine basic fibroblast growth factor; collect the prepared sodium a...

Embodiment 3

[0081] A sodium alginate fiber bundle / polypeptide hydrogel containing double drugs to promote wound healing is prepared by the following preparation method, including the following steps:

[0082] Step (1), dissolving 1 μg of recombinant bovine basic fibroblast growth factor in 10mL of 3wt% sodium alginate aqueous solution to form a mesophase solution; dissolving 3g of calcium chloride powder in 100mL of isopropanol and stirring until completely dissolved , prepared into 3% w / v calcium chloride isopropanol solution as the external phase solution; pump 1mL of the intermediate phase solution and 100mL of the external phase solution into the syringe, inject them into the internal and external phases of the microfluidic chip, and the internal phase The flow rate of the external phase is 50 μL / min, and the flow rate of the external phase is 500 μL / min to prepare sodium alginate fiber bundles loaded with recombinant bovine basic fibroblast growth factor; collect the prepared sodium a...

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Abstract

The invention discloses a fiber bundle / polypeptide hydrogel containing double drugs for promoting wound healing, which is prepared into sodium alginate fiber bundles by using a sodium alginate solution containing drugs for promoting wound healing through microfluidic "spinning" technology ; Then compound the sodium alginate fiber bundle with the polypeptide pregel solution containing antibacterial drugs to obtain a hydrogel pregel system, and self-assemble to form a sodium alginate fiber bundle / polypeptide hydrogel composite drug-loading system. The double-drug drug-carrying system of the present invention is a material with sustained release of drugs wrapped in sodium alginate fiber bundles inside and rapid release of antibacterial drugs wrapped in polypeptide hydrogel outside, which can treat wound infection and release drugs slowly during the wound healing process Promote healing, can effectively shorten the acute inflammatory period of chronic wounds, and promote rapid wound healing; it can also provide a moist environment for the wound, ensure a certain degree of air permeability on the wound surface, and has a wide range of application values ​​in the treatment of chronic wounds and other wounds.

Description

technical field [0001] The invention relates to a fiber bundle / polypeptide hydrogel containing double drugs to promote wound healing and a preparation method thereof. Background technique [0002] Wound healing is mainly divided into three stages: acute inflammation stage, cell proliferation stage, and scar repair stage. Chronic wounds have always been in the inflammatory phase, or re-infected after the wound has healed, resulting in a high incidence of chronic wounds and poor healing, causing many patients to suffer. According to the survey, many patients suffer from skin disorders such as chronic wounds or large-area wounds after surgery every year, and bear a large amount of treatment costs. Wound healing is a complex dynamic process, including pH changes, protease activation, and vascular tissue regeneration, and is affected by various external factors, such as the patient's inherent constitution and the external recovery environment. In the process of treating wound i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/42A61K38/18A61K31/43A61P17/02
CPCA61K9/06A61K31/43A61K38/1825A61K47/36A61K47/42A61P17/02A61K2300/00
Inventor 岳婉晴钟文英崔天宇李秀平何苏云
Owner CHINA PHARM UNIV
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