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Injectable hydrogel adhesive capable of rapidly stopping bleeding as well as preparation method and application of injectable hydrogel adhesive

A hydrogel adhesive and hydrogel technology, applied in the fields of application, surgical adhesives, medical science, etc., can solve the problems of low strength and rapid disintegration of materials, so as to improve mechanical properties and maintain biocompatibility , the effect of preventing adhesion

Active Publication Date: 2022-07-08
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese patent CN110404083A discloses an injectable hydrogel material and its preparation method and application, although it also discloses a carboxymethyl chitosan-based, Injectable hydrogels reacted with dialdehydelated polysaccharides, auxiliary cross-linking agents, and aldehydated contrast agents, but this injectable hydrogel only relies on the dynamic Schiff base reaction of carboxymethyl chitosan and dialdehydelated polysaccharides. Glue still has the problem of low strength, and carboxymethyl chitosan has the problem of rapid disintegration of the material after it is completely swollen in the body due to its good water solubility

Method used

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  • Injectable hydrogel adhesive capable of rapidly stopping bleeding as well as preparation method and application of injectable hydrogel adhesive
  • Injectable hydrogel adhesive capable of rapidly stopping bleeding as well as preparation method and application of injectable hydrogel adhesive
  • Injectable hydrogel adhesive capable of rapidly stopping bleeding as well as preparation method and application of injectable hydrogel adhesive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] (1) At room temperature, dissolve 2 g of chitosan in 90 ml of water, and then add 10 g of acrylic acid for overnight.

[0056] (2) Take 20 g of the above solution, add 0.2 g of methacrylic anhydride gelatin, 0.2 g of α-ketoglutaric acid, and 0.2 g of N-acryloyloxysuccinimide, and stir until transparent.

[0057] (3) Pour into the mold of the acrylic plate and cross-link in the UV cross-linking box for 30min.

[0058] (4) Take out the sample and freeze-dry it with a vacuum freeze dryer.

[0059] (5) The lyophilized sample was put into a grinding jar at 50 Hz, and ground for 1 min to obtain the first component.

[0060] (6) Under normal temperature (of course, it can also be under other temperature conditions of 10-25°C), in 4wt% sodium alginate solution, add sodium periodate, and react in the dark for 12h; then add polyethylene glycol to react 2h, then dialyzed in deionized water, then dried, and then ground to obtain aldehyde group-terminated sodium alginate powder, n...

Embodiment 2

[0066] (1) At room temperature, dissolve 2g of carboxyethyl chitosan in 90ml of water, and then add 10g of acrylic acid for overnight.

[0067] (2) Take 20 g of the above solution, add 0.2 g of methacrylic anhydride gelatin, 0.2 g of α-ketoglutaric acid, and 0.2 g of N-acryloyloxysuccinimide, and stir until transparent.

[0068] (3) Pour into the mold of the acrylic plate and cross-link in the UV cross-linking box for 30min.

[0069] (4) Take out the sample and freeze-dry it with a vacuum freeze dryer.

[0070] (5) The lyophilized sample was put into a grinding jar at 50 Hz, and ground for 1 min to obtain the first component.

[0071] (6) At room temperature, in 4wt% sodium alginate solution, add sodium periodate, and react in the dark for 12 hours; then add polyethylene glycol for 2 hours, then dialyze in deionized water, then dry and grind again. An aldehyde group-terminated sodium alginate powder is obtained.

[0072] (7) Dissolving 20 g of oxidized sodium alginate in 80 g...

Embodiment 3

[0077] (1) At room temperature, dissolve 6g of chitosan in 60ml of water, and then add 40g of acrylic acid overnight.

[0078] (2) Take 20 g of the above solution, add 0.02 g of methacrylic acid anhydride gelatin, 0.1 g of α-ketoglutaric acid, and 0.2 g of N-acryloyloxysuccinimide, and stir until transparent.

[0079] (3) Pour into the mold of the acrylic plate and cross-link in the UV cross-linking box for 30min.

[0080] (4) Take out the sample and freeze-dry it with a vacuum freeze dryer.

[0081] (5) The lyophilized sample was put into a grinding jar at 50 Hz, and ground for 1 min to obtain the first component.

[0082] (6) At room temperature, in 4wt% sodium alginate solution, add sodium periodate, and react in the dark for 12 hours; then add polyethylene glycol for 2 hours, then dialyze in deionized water, then dry and grind again. An aldehyde group-terminated sodium alginate powder is obtained.

[0083] (7) Dissolving 20 g of oxidized sodium alginate in 80 g of water...

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Abstract

The invention belongs to the technical field of medical polymer materials, and discloses an injectable hydrogel adhesive capable of rapidly stopping bleeding as well as a preparation method and application of the injectable hydrogel adhesive capable of rapidly stopping bleeding. A precursor of the injectable hydrogel adhesive capable of rapidly stopping bleeding comprises a first component and a second component, and the first component simultaneously comprises a chitosan component and a polyacrylic acid hydrogel component; the second component simultaneously comprises non-aldehyde polysaccharide, dialdehyde polysaccharide and a cationic salt solution; after the first component and the second component are mixed, hydrogel can be formed through in-situ crosslinking by means of Schiff base reaction, and the hydrogel can be used as a hydrogel adhesive for rapid hemostasis. The hydrogel adhesive based on two components is obtained by improving the composition of the hydrogel adhesive and the precursor of the hydrogel adhesive, has the characteristics of being injectable and rapid in gelling, has no requirements on the position and form of a wound surface in the use process, and can effectively overcome the difficulty of the existing hemostatic material in hemostasis of irregularly-shaped and non-compressible wounds.

Description

technical field [0001] The invention belongs to the technical field of medical polymer materials, and more particularly relates to an injectable and rapid hemostasis hydrogel adhesive, a preparation method and an application. Background technique [0002] Controlling bleeding from wounds is a critical issue, with more than 30% of traumatic deaths worldwide due to uncontrolled blood loss, and more than half of all deaths occur before first aid arrives. Rapid and effective hemostasis of irregularly shaped, uncompressed wounds is also a major challenge in surgical operations. Excessive blood loss can cause low blood pressure, damage to organ function, and even death. [0003] Existing hemostatic materials include gauze, medical sponge, hemostatic gel and hemostatic powder. Gauze and medical sponges promote the body's own coagulation by absorbing a large amount of liquid components in the blood, thereby increasing the concentration of coagulation factors in the wound. Existin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08
CPCA61L24/08A61L24/06A61L24/104A61L24/02A61L24/0015A61L24/0031A61L24/001A61K47/36A61K47/32A61K47/42A61K47/02A61K9/06A61K9/0019A61P7/04C08B37/003C08B37/0084C08H1/00C08F251/00A61L2400/06A61L2400/04A61L2300/602A61L2300/414C08L5/08C08L33/02C08L33/26C08L5/04C08L5/00C08F220/06C08F220/56C08F220/54C08F220/36
Inventor 臧剑锋杨月莹
Owner HUAZHONG UNIV OF SCI & TECH
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