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Polyurethane as well as preparation method and application thereof

A technology of polyurethane and polymerization reaction, which is applied in the field of medical materials, can solve the problems of affecting the service performance and life of materials in vivo, high requirements for reaction conditions, and high risk of azide groups, etc., and achieves simple methods, simple processing, and mild conditions Effect

Active Publication Date: 2022-02-08
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the synthesis process of this type of method is relatively complicated, and the requirements for reaction conditions are relatively high, and the azide group has a high risk in the process of use.
[0005] On the other hand, when polyurethane medical devices are implanted in the body for a long time, they will cause creep due to long-term fatigue stress, which will affect the in vivo service performance and life of the material, and will also limit its further application.

Method used

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  • Polyurethane as well as preparation method and application thereof
  • Polyurethane as well as preparation method and application thereof
  • Polyurethane as well as preparation method and application thereof

Examples

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preparation example Construction

[0060] The present invention also provides a kind of preparation method of above-mentioned polyurethane, comprises the following steps:

[0061] Polymerize the chain extender, diisocyanate and polymer diol by one-step method, two-step method or semi-prepolymerization method to obtain polyurethane;

[0062] The polymerization reaction is bulk polymerization or solvent polymerization.

[0063] In the preparation method of polyurethane provided by the present invention, the raw material components and proportions used are the same as above, and will not be repeated here.

[0064] In some embodiments of the present invention, the polymerization reaction may be a one-step solvent polymerization reaction, or a two-step solvent polymerization reaction, or a one-step bulk polymerization reaction.

[0065] In some embodiments of the present invention, the preparation method of the one-step solvent polymerization includes:

[0066] In the mixed solvent, add polymer diol and heat up to...

Embodiment 1

[0096] one-step solvent polymerization

[0097] Add 400mL of a mixed solvent of tetrahydrofuran and N,N-dimethylacetamide (volume ratio 1:4), 50g of polycarbonate diol (polycarbonate containing 1,6-hexanediol) into a four-neck flask (i.e. polycarbonate-1,6-hexanediol), the weight average molecular weight is 1000) after stirring, the temperature is raised to 70°C; add chain extender 10g ethylene glycol, 5g quaternary ammonium-furan diol (with formula The structure shown in (I), m 1 = 2, n 1 = 3, n 2 =3) and 5g quaternary ammonium-maleimide glycol (with structure shown in formula (II), m 2 = 2, n 3 = 3, n 4 =3) Stir fully to dissolve the reactant completely; finally add 20g of 4,4'-diphenylmethane diisocyanate (MDI), raise the temperature to 120°C, and react for 6 hours, then cool down to 70°C to stop stirring and cool to obtain polycarbonate Ester polyurethane solution.

Embodiment 2

[0099] one-step solvent polymerization

[0100] Add 400mL of a mixed solvent of tetrahydrofuran and N,N-dimethylacetamide (volume ratio: 1:4), 50g of polytetramethylene glycol (weight average molecular weight: 1000) into a four-neck flask, stir and heat up to 70°C; add Chain extender 10g ethylene glycol, 5g quaternary ammonium-furan diol (m 1 = 2, n 1 = 3, n 2 =3) and 5g quaternary ammonium-maleimide glycol (m 2 = 2, n 3 = 3, n 4=3) Stir well to dissolve the reactants completely; finally add 20g of 4,4'-diphenylmethane diisocyanate (MDI), raise the temperature to 120°C, stop stirring after 6 hours of reaction and cool down to obtain a polyurethane solution.

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Abstract

The invention relates to the technical field of medical materials, in particular to polyurethane as well as a preparation method and application thereof. The polyurethane is obtained by polymerizing a chain extender, diisocyanate and macromolecular dihydric alcohol; wherein the chain extender comprises a component A, a component B and a component C, the component A comprises dihydric alcohol containing a quaternary ammonium-furan structure or diamine containing the quaternary ammonium-furan structure; the component B comprises dihydric alcohol containing a quaternary ammonium-maleimide structure or diamine containing the quaternary ammonium-maleimide structure; and the component C is micromolecular dihydric alcohol and / or micromolecular diamine; The quaternary ammonium cations of polyurethane in a rigid chain segment have an antibacterial function; the furan and maleimide groups carried by the chain extender do not influence the synthesis and processing of polyurethane at a high temperature, and then a cross-linking reaction can be carried out again at a low temperature, so that post-heating cross-linking treatment between polyurethane hard segments is realized, and the creep resistance of the material is enhanced.

Description

[0001] This application claims the priority of the Chinese patent application submitted to the China Patent Office on July 21, 2021, the application number is 202110823673.7, and the invention title is "An antibacterial polyurethane, its preparation method and application", the entire content of which is incorporated herein by reference. Applying. technical field [0002] The invention relates to the technical field of medical materials, in particular to a polyurethane, its preparation method and application. Background technique [0003] Polyurethanes (TPUs) refer to a class of thermoplastic elastic block polymer materials composed of soft segments and hard segments. Among them, polyester or polyether diol constitutes the soft segment of TPUs, and diisocyanate and small molecule diol or diamine chain extender form the hard segment. Due to the incompatibility between the soft segment and the hard segment in the polyurethane molecule, the hard segments are easily aggregated ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/67C08G18/66C08G18/44C08G18/48C08G18/32A61L31/06A61L31/16
CPCC08G18/675C08G18/6655C08G18/6688C08G18/44C08G18/4854C08G18/3293C08G18/3206A61L31/06A61L31/16C08L75/04C08L75/08
Inventor 宋凌杰石恒冲栾世方杨华伟殷敬华闫顺杰张德海张鹏翔黄岐善陈卓
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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