Hibiscus sabdariffa anthocyanin extract as well as preparation method and application thereof

Abstract

The invention provides a preparation method of a hibiscus sabdariffa anthocyanin extract. The extraction process is simple, no pollution is caused, and the anthocyanin content is high. The hibiscus sabdariffa anthocyanin extract prepared by the preparation method disclosed by the invention is wide in application, and can be applied to multiple fields of foods, preparation of health-care products and / or medicines. The invention further provides an application of the hibiscus sabdariffa anthocyanin extract to preparation of a medicine for preventing or relieving colitis. The hibiscus sabdariffa anthocyanin extract has the specific effects on preventing or relieving colitis as follows: the hibiscus sabdariffa anthocyanin extract can relieve weight loss of dextran sodium sulfate induced colitis mice, reduce the inflammation level in serum and tissues, relieve shortening and edema of colon, protect intestinal mucosa barriers, increase the total content of short-chain fatty acids in the intestinal tract, maintain the stable state of intestinal flora, and reduce the abundance of harmful bacteria in the intestinal tract.

Description

technical field [0001] The invention belongs to the technical field of plant component extraction, and in particular relates to a roselle anthocyanin extract, a preparation method and application thereof. Background technique [0002] Inflammatory bowel disease (Inflammatory bowel disease, IBD) is a kind of chronic and easily relapsing disease that occurs in the digestive tract, mainly divided into Crohn's disease (CD) and ulcerative colitis (Uulcerativecolitis, UC). In CD, segmental, asymmetric, and transmural inflammatory infiltration is present, and there is a possibility of continuous damage to each segment of the gastrointestinal tract, usually accompanied by complications such as abscess, fistula, and stenosis. The entire area of ​​the digestive tract from the mouth to the anus. In contrast, UC is characterized by mucosal inflammation limited to the colonic segment, causing recurrence and metastasis of prolonged mucosal inflammation, starting in the rectum and extendi...

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Problems solved by technology

At present, there are also reports about the extraction of roselle anthocyanins and their applications. Roselle extracts have been proven to have anti-aging, blood fat-lowering, antibacterial and other effects. For example: the Chinese patent with publication number CN 108938691A (a kind of Roselle extract and its extraction method and application) disclose the Roselle extract with anti-aging effect by extracting with ethanol, then extracting the ethanol extract with cyclohexane; studies such as Chang show that taking Roselle extract Can reduce serum free fatty acids (Chang et al. Hibiscus sabdariffa extract inhibits obesity and fataccumulation, and improves liver steatosis in humans [J]. Food & Function, 2014, 5.); Liu et al. found that roselle calyx and its extracts are resistant to methoxy Inhibitory effect on the growth of Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii (Liu et al.In vitro antibacterial activity of roselle calyx and protocatechuic acid[J].Phytotherapy Research,2010, 19 (11): 942-945.); Publication number is that the Chinese patent of CN 108558971A has announced a kind of preparation method of roselle anthocyanin, yet, the extraction method used in above-mentioned content only uses macroporous resin to purify, can't realize the extraction of anthocyanin Highly enriched, the specific content of anthocyanins in the extract is not calibrated or there are still a large number of other flavonoids in the extract, and there is no research on the prevention or auxiliary treatment of roselle anthocyanins in the prevention or auxiliary treatment of colitis and other inflammatory bowel diseases at home and abroad. research report

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