Yak type I collagen product for repairing light injury of skin

A technology of collagen and light damage, applied in the field of yak type I collagen products, can solve the problems of poor skin repair effect, achieve the effects of convenient storage and use, promote the growth of epidermal cells, and improve inflammation symptoms

Active Publication Date: 2021-10-26
胶原蛋白(武汉)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, skin photodamage can be treated locally with topical corticosteroids or soothing lotions in the absence of blisters, but the above methods are less effective in repairing photodamaged skin

Method used

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  • Yak type I collagen product for repairing light injury of skin
  • Yak type I collagen product for repairing light injury of skin
  • Yak type I collagen product for repairing light injury of skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The preparation of embodiment 1 yak type I collagen

[0053] 1. Preparation method

[0054] Wash the yak tendons, remove foreign matter, and crush them into small pieces; treat the pulverized small pieces with 1% chlorhexidine and 5% hydrogen peroxide, take the precipitate, wash it with water until neutral; wash the obtained precipitate with 10 Degrease with % n-butanol, take the precipitate, wash with water until neutral; decalcify the precipitate obtained in the previous step with 0.5M hydrochloric acid, after decalcification is complete, take the precipitate, wash with water until neutral; the tissue precipitate obtained in the previous step Soak in 0.5M sodium hydroxide solution, stir at 10°C for 2 hours, take the precipitate, wash with water until neutral; extract collagen with 0.5M acetic acid solution containing 1g / L pepsin to obtain a crude collagen extract; pH to neutral, enzyme inactivation; 8-14kDa dialysis bag for dialysis, after dialysis, freeze-drying, an...

Embodiment 2

[0064] Example 2 Preparation of skin photodamage repair liquid complex

[0065] The skin photodamage repair liquid complex is made of the following components by mass ratio: yak collagen 10%, butylene glycol 10%, erythritol 8%, avocado tree extract 1%, glycerin 5%, niacinamide 3% , hyaluronic acid 2%, bisabolol 0.5%, methylparaben 0.14%, and the balance is water.

[0066] Preparation process: Heat phase A substances (water, glycerin, erythritol, nicotinamide, hyaluronic acid) to 85 degrees, stir until completely dissolved, homogenize for 3 minutes, and keep warm for 10-15 minutes; pre-dissolve phase B substances (butadiene Diol), completely dissolved until transparent, cooled to 70 degrees and added; pre-dissolved phase C substances (shea tree extract, yak collagen), phase D substances (methylparaben, bisabolol); cooled to 40 degrees Add phase D substance, cool down to 35 degrees, add phase C substance, stir until completely dissolved and transparent. Cool down to 30 degrees...

Embodiment 3

[0067] Embodiment 3 Preparation of skin photodamage repair cream complex

[0068] The skin photodamage repair cream complex is made of the following components by mass ratio: 15% yak collagen, 10% butanediol, 8% glycerin, 7% betaine, 6% caprylic / capric triglyceride, poly Silicone 6%, Cetearyl Glucoside 3%, Chamomile Flower Extract 1%, Glyceryl Stearate 1%, Sodium Hyaluronate 1%, Phenoxyethanol 0.2%, Centella Asiatica Extract 0.1% , and the balance is water.

[0069] Stir the phase A material (caprylic acid / capric triglyceride, cyclohexane, polydimethylsiloxane, glyceryl stearic acid, cetearyl glucoside) to 90 degrees, and stir evenly. Phase B substances (water, glycerin, betaine, sodium hyaluronate) were stirred and heated to 90 degrees, stirred evenly, and then the substances in phase A were vacuum pumped into phase B, the two phases were mixed and emulsified, homogenized for 3-5 minutes, and stirred evenly , keep warm for 10-20 minutes; cool down to 45 degrees, then add C-...

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Abstract

The invention belongs to the field of skin light-injury repair and particularly relates to a yak type I collagen product for repairing light injury of skin. According to the yak type I collagen product, it is discovered that a yak type I collagen has a remarkable repairing effect on skin injured by ultraviolet light and can be used for improving inflammation symptoms after skin injury, promoting epidermal cell growth of the skin and inducing proliferation and differentiation of epidermal cells; and meanwhile, moisture of an epidermal layer can be kept, repair and reconstruction of collagenous fibers are promoted, and thus, the yak type I collagen can be applied to preparation of skin light-injury repair products. The invention also provides a skin light-injury repairing composition containing the yak type I collagen, and the skin light-injury repairing composition can be used for improving inflammation symptoms of the skin after the light injury, promoting the growth of the epidermal cells and increasing the content of collagen in the injured skin and has a remarkable skin light-injury repairing effect.

Description

technical field [0001] The invention belongs to the field of skin photodamage repair, and in particular relates to a yak type I collagen product used for skin photodamage repair. Background technique [0002] Skin photodamage is mainly acute and chronic damage caused by UV directly or indirectly to the skin, including phototoxicity, photosensitivity, photoaging and photocarcinogenesis. It is inevitable to be irradiated by sunlight in daily life, and the damage of ultraviolet rays in the sun to human skin cannot be ignored. Most of the ultraviolet rays in sunlight are UVA with a wavelength of 320-400nm, about 50% of UVA penetrates into the epidermis, and is deeper than UVB radiation, through the photooxidation of melanin or direct skin pigmentation (Meirowsky effect), resulting in rapid But long-lasting tan; and is also a major cause of photoaging, photosensitivity and damage to the retina and the appearance of cataracts. Sunlight contains a small part of UVB with a wavelen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61P17/00A61P17/16A61K8/65A61Q19/00A23L33/17
CPCA61K38/39A61P17/00A61P17/16A61K8/65A61Q19/004A23L33/17A23V2002/00A23V2200/318A23V2250/5422
Inventor 肖建喜付彩虹
Owner 胶原蛋白(武汉)生物科技有限公司
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