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Application of titanium oxide-loaded silver monatomic material in virus killing

A titanium oxide and atomic technology, applied in the field of biomedicine, can solve the problems of poor virus targeting, low catalytic activity, and body toxicity, and achieve the effects of good stability, high biological safety, and strong sensitivity

Pending Publication Date: 2021-09-17
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Silver nanoparticles have a good effect, but the surface dispersion of silver in nanoparticles is usually lower than 5 wt%, which means that only less than 5% of the silver atoms on the surface can exert the effect, which causes waste of resources on the one hand and is not used by others. The silver atoms used may be toxic to the body
Nano-titanium oxide also has a certain ability to convert hydrogen peroxide into hydroxyl radicals, and at the same time has biological safety, but its catalytic activity is relatively low and its targeting to viruses is poor

Method used

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  • Application of titanium oxide-loaded silver monatomic material in virus killing
  • Application of titanium oxide-loaded silver monatomic material in virus killing
  • Application of titanium oxide-loaded silver monatomic material in virus killing

Examples

Experimental program
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Effect test

Embodiment 1

[0086] The geometrical characterization of silver single atoms is shown in Figure 1. Scanning Electron Microscopy (SEM) and Dynamic Light Scattering (DLS) experiments were first used to examine whether Ag loading resulted in aggregated TiO 2 ; the results show that the carrier still has a uniform size distribution after loading, with a size of 10-15 nm (Fig. 1b-c). As shown in Fig. 1d–e, Ag atoms are dispersed in TiO 2 In Ag single atoms on the carrier, Ag, Ti and O elements are well distributed in the whole space. In contrast, when Ag NPs were observed, particles with a size of 3–5 nm were detected (Fig. 1f–g). Ag-TiO was investigated by Raman and solid-state ultraviolet-visible absorption spectroscopy (UV-vis) 2 The interaction spectrum of ( Figure 1h ). The peak around 450 nm is attributed to a size larger than 3 nm, further confirming the existence of Ag NPs. Figure 1i shows the TiO before and after Ag doping 2 The characteristic peak of , remained unchanged, but ...

Embodiment 2

[0088] Adsorption capacity of single-atom materials for coronaviruses: the analysis of single-atom materials with Ag loadings of 0.2 wt% and 1 wt% for SARSCoV 2The absorption capacity of pseudoviruses. The results showed that SAN loaded with 1% Ag exhibited a higher ability to adsorb pseudoviruses (Fig. 2a). We also compared and analyzed the adsorption capacity of the pseudovirus with the Ag loading of 1 wt% Ag single atom, the loaded Ag nanoparticles and the carrier. Surprisingly, the adsorption capacity of Ag single atoms to pseudoviruses was 99.65%, and the adsorption capacities of Ag nanoparticles and nano-TiO2 were only 90.62% and 82.71% (Fig. 2b–c). Finally, we confirmed the direct interaction between single atoms and pseudoviruses by scanning electron microscopy. Interestingly, we observed that pseudoviruses (smaller particles) were absorbed onto the surface of TiO-supported Ag single-atom materials (larger particles) (Fig. 2d–e). In skin test assays, Ag monoatomic a...

Embodiment 3

[0091] The reason for the ability of monatomic materials to adsorb viruses: Spike protein is SARS-CoV 2 The outermost structure responsible for binding to the host cell. We speculate that this uptake is partly dependent on the interaction of silver atoms with the spike protein. In this work, different materials were co-incubated with Spike 1 protein RBD, and then the supernatant was extracted for immunoassay. PBS is the blank control group of phosphate buffered saline, MOCK represents the cell group without material treatment; SAN represents the cell group treated with titanium oxide-loaded silver single atoms, and Ag represents the cells treated with titanium oxide-loaded silver nanoparticles Group, TiO 2 represents the group of cells treated with pure vehicle, TiO 2 +Ag refers to the group of cells treated with both titanium oxide support and silver ions. like Figure 3a As shown in -b, the absorption of S1RBD by Ag single atoms is higher than that of TiO 2 , Titanium ...

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Abstract

The invention belongs to the field of biological medicine, and particularly relates to an application of a loaded silver monatomic material in virus killing, the titanium oxide silver monatomic loaded material has the following structure: silver monatomic is stably anchored on the surface of titanium oxide and / or in a skeleton in a monodisperse form, and the bonding mode is Ti-O-Ag; the band gap range of the electronic structures of the Ag single atoms and the titanium oxide is 2.9-3.2 eV due to embedding of the Ag single atoms; the titanium oxide-loaded silver monatomic material has more excellent catalytic activity than silver nanoparticles and peroxidase activity, broad-spectrum virus killing is realized by utilizing the principle that hydroxyl free radicals can efficiently destroy nucleic acid and protein, and the electronic structure band gap of Ag monatomic and titanium oxide is reduced by chimeric silver monatomic, the sensitivity to visible light is higher, and photodynamic virus killing can be induced by photocatalysis under light irradiation.

Description

technical field [0001] The invention belongs to the field of biomedicine, and particularly relates to the application of a titanium oxide-supported silver single atom material in virus elimination. Background technique [0002] There are many highly infectious coronavirus variants such as SARS virus and new coronary pneumonia virus. Today's drugs and vaccines cannot cope with the emerging variants. Therefore, it is urgent to develop a broad-spectrum and high-efficiency treatment against coronavirus and various variants. New materials with low killing, low drug resistance, safety and reliability lay the foundation for large-scale killing. [0003] The novel coronavirus pneumonia (COVID-19) has continued to spread around the world since its outbreak, posing a serious threat to the public health security of more than 200 countries. The novel virus that causes this severe acute respiratory syndrome, called SARS-CoV-2, is a single-stranded RNA virus. [0004] It has been report...

Claims

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Application Information

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IPC IPC(8): A01N59/16A01N25/04A01P1/00B82Y30/00B82Y40/00B82Y5/00A61K41/00A61K47/69A61P31/14
CPCA01N59/16A01N25/04B82Y30/00B82Y40/00B82Y5/00A61K41/0057A61K47/6923A61P31/14
Inventor 聂国辉张斌王大吉丁辉刘洋
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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