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Flexible electrochemical glucose sensor based on laser direct writing and preparation method thereof

A glucose sensor, electrochemical technology, applied in the direction of material electrochemical variables, scientific instruments, instruments, etc., can solve the problems of low integration and complex preparation of sensing materials

Pending Publication Date: 2021-09-10
EAST CHINA UNIV OF SCI & TECH
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Problems solved by technology

Patent Document 2 discloses an enzyme-free glucose electrochemical sensor based on a flexible Ni-P paper electrode and its preparation method and application. Through the construction of a Ni-P paper-based electrode, the flexibility and catalytic activity of the detection electrode are increased, thereby improving the detection sensitivity. , but the preparation of the sensing material is still relatively complicated and the integration level is not high

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  • Flexible electrochemical glucose sensor based on laser direct writing and preparation method thereof
  • Flexible electrochemical glucose sensor based on laser direct writing and preparation method thereof
  • Flexible electrochemical glucose sensor based on laser direct writing and preparation method thereof

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preparation example Construction

[0050] [Preparation method of flexible electrochemical glucose sensor]

[0051] Refer to the following figure 1 The method for producing the flexible electrochemical glucose sensor of the present invention (hereinafter also referred to as "the method for producing the sensor of the present invention") will be described.

[0052] The preparation method of the flexible electrochemical glucose sensor of the present invention comprises the following steps (1) to (5).

[0053] step 1)

[0054] Prepare a planar polyimide film, and use an ultraviolet ozone cleaner to irradiate the surface of the polyimide film to improve surface hydrophilicity.

[0055] In some preferred embodiments, the polyimide film can be wiped with organic solvents such as ethanol and acetone to clean the surface before irradiation with an ultraviolet ozone cleaner.

[0056] In some preferred embodiments, the wavelength of the ultraviolet light source is used to be 185 and 254nm ultraviolet ozone cleaning m...

Embodiment

[0077] The structure and advantages of the present invention will be further described through the following examples, but it should be understood that the following examples are only illustrations for implementing the present invention, and are not intended to limit the protection scope of the present invention.

[0078] (Preparation of flexible electrochemical glucose sensor)

[0079] Prepare a polyimide film with a thickness of 0.125 mm, and wipe clean the surface with ethanol. Use the wavelength of ultraviolet light source as 185 and 254nm ultraviolet ozone cleaning machine to irradiate polyimide substrate, make polyimide film substrate 2cm away from ultraviolet light source, and irradiate 10 minutes, thus make substrate surface generate active group, Improve surface hydrophilicity.

[0080]Add 2.5g of copper nitrate and 2.5g of ethylene glycol in a beaker, and stir the mixed solution of copper nitrate and ethylene glycol on a magnetic stirrer until the copper nitrate is ...

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Abstract

The invention provides a flexible electrochemical glucose sensor and a preparation method thereof, the sensor is provided with a planar three-electrode composed of a working electrode, a reference electrode and a counter electrode which are located on the same plane of a polyimide film substrate, the working electrode is composed of a graphene layer and a copper oxide layer coated on at least one part of the surface of the graphene layer, the reference electrode is composed of a graphene layer and an Ag / AgCl conductive layer coated on at least a part of the surface of the graphene layer, the counter electrode is composed of a graphene layer, the working electrode, the reference electrode and the counter electrode are arranged at a predetermined interval from each other, and the Ag / AgCl conductive layer in the reference electrode is arranged facing the counter electrode. The sensor has the advantages of wide linear detection range, simplicity in processing and preparation, low production cost and easiness in batch production, is good in stability after being bent for multiple times, can be integrated with flexible temperature, pressure and strain sensors, and has wide application prospects in the fields of human health detection, biomedical treatment and the like.

Description

technical field [0001] The invention belongs to the technical field of sensor manufacturing, in particular to a flexible electrochemical glucose sensor based on laser direct writing and a preparation method thereof. Background technique [0002] According to the International Diabetes Federation (International Diabetes Mellitus, IDF), by 2019, about 463 million people worldwide will suffer from diabetes, that is, 9.3% of adults aged 20 to 79 will suffer from diabetes, and one in 11 people will be diabetic. Blood glucose concentration is one of the important indicators for early detection and treatment of diabetes. Therefore, rapid and accurate detection of glucose concentration has important practical significance. At present, glucose sensors are mainly divided into enzyme-based sensors and non-enzyme sensors. [0003] Enzyme-based sensors have high selectivity and good sensitivity to glucose, but such sensors have consumption and irreversible reactions. These devices usua...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30
CPCG01N27/308G01N27/301
Inventor 轩福贞高阳杨大圣王紫阳张颢出
Owner EAST CHINA UNIV OF SCI & TECH
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