Surface sterilization antiviral spray as well as preparation method and application thereof

An anti-virus and spray technology, applied in the direction of anti-viral agents, biochemical equipment and methods, anti-inflammatory agents, etc., to achieve the effects of fast action speed, good stability, and strong penetration

Inactive Publication Date: 2021-07-23
山东莱博生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching, it is related to the use of lysozyme, tetrapyridinium chloride, glycyrrhizic acid, a viral protein receptor ACE2 inhibitor, and hydrogen-rich water, combined with acesulfame potassium and menthol to prepare an oropharyngeal surface, hand surface, and antiviral spray for epidemic prevention of new coronaviruses. agent has not been reported yet

Method used

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  • Surface sterilization antiviral spray as well as preparation method and application thereof
  • Surface sterilization antiviral spray as well as preparation method and application thereof
  • Surface sterilization antiviral spray as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]Embodiment 1: Preparation of antibacterial and antiviral spray on oropharyngeal surface and hand surface

[0032] Specifically, take the preparation of 100ml oropharyngeal face and hand surface bactericidal antiviral spray as an example:

[0033] (1) Based on the preparation of 100ml of spray, add 70ml of hydrogen-rich water to the stirring tank at room temperature, then add 0.2g of lysozyme to 4 million units / 100ml, 0.1g of tetrapyridyl ammonium chloride, and glycyrrhizic acid 0.01g, 0.03g acesulfame potassium, 0.1g menthol, dilute hydrogen-rich water to 100ml, stir until completely uniform and set aside;

[0034] (2) Test the pH value to determine whether the pH value reaches 6.0-6.8. If the pH value is between 6.0-6.8, it can be filled; if the pH value is not up to the standard, adjust the pH value to 6.0-6.8 with citric acid. Or more preferably 6.3.

Embodiment 2

[0035] Embodiment 2: Disinfection evaluation of antibacterial and antiviral spray on oropharyngeal surface and hand surface

[0036] 2.1 Microbial killing test

[0037] 2.1.1 Preparation of bacteria suspension and bacteria slices Bacterial species: Escherichia coli 8099, Staphylococcus aureus ATCC6538, Pseudomonas aeruginosa ATCC15442, Candida albicans ATCC10231.

[0038] 2.1.2 The test was carried out according to the bactericidal test method stipulated in the 2002 edition of the "Technical Specifications for Disinfection".

[0039] Table 1: Evaluation of Microbial Killing Effect

[0040]

[0041]

[0042] 2.2 On-the-spot experiment of oral and facial antibacterial and antiviral sprays on oral disinfection

[0043] 2.2.1 At the site of use, randomly select subjects. The test shall not be less than 30 person-times.

[0044] 2.2.2 Before disinfection, the subject washes his hands, rinses his mouth with water, soaks it in a test tube containing 10ml of diluent with a s...

Embodiment 3

[0052] Example 3: Protection evaluation of antibacterial and antiviral spray on oropharyngeal surface and hand surface

[0053] 3.1 Antibacterial zone method to test the bactericidal and antibacterial effect of oral and facial antiviral spray

[0054] 3.1.1 Prepare 2 bottles of 100mL LB liquid medium (yeast extract 5g / L, tryptone 10g / L, NaCl 10g / L, agar powder 15g / L), autoclave at 121°C for 20min, and insert Escherichia coli respectively after cooling 1 slant strain, 1 slant strain of Staphylococcus aureus. Shake well and incubate at 37°C for 1-2 days until cloudy.

[0055] 3.1.2 In the ultra-clean workbench, put 100mL of nutrient agar medium at about 45°C, shake well, then pour the medium into a dish, wait for it to solidify, and pour it into 4 petri dishes. Use a sterile pipette to draw 0.2 mL of Escherichia coli (8099) suspension and 0.2 mL of Staphylococcus aureus (ATCC6538), and spread them on the culture medium.

[0056] 3.1.3 Take the sterile circular filter paper pi...

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Abstract

The invention discloses a surface sterilization antiviral spray for oropharynx, face and hands. The surface sterilization antiviral spray is prepared from lysozyme, tetrapyridinium chloride, glycyrrhizic acid, acesulfame potassium, menthol and hydrogen-rich water. The invention also discloses application of the spray as a medicine product on the oropharynx, face and/or hands for surface sterilization and virus resistance, especially resistance to novel coronavirus SARS-CoV-2. The spray has the advantages of broad-spectrum disinfection, extremely strong seepage force, high acting speed, good stability, low toxicity, no corrosion, small irritation and good environment-friendly feature, and is particularly easy to form a layer of invisible protective film on the surface of oral mucosa, face and skin, especially on the surface of a hand, so that the infection from bacteria and viruses is effectively prevented, and the long-time antibacterial and antiviral effects are achieved. Therefore, the surface sterilization antiviral spray has a wide application prospect.

Description

technical field [0001] The invention relates to a spray and its preparation method and application, in particular to a bactericidal and antiviral spray on oropharyngeal surface, hand surface, and its preparation method and application. The invention belongs to the technical field of chemical disinfectants. Background technique [0002] The existence of harmful microorganisms will bring many diseases to humans, and even endanger human life in severe cases. Disinfection is an effective measure to maintain the safety of human life. In daily life, various disinfectants are often used. [0003] At present, the active ingredients of commonly used disinfectants mainly include the following types of substances: oxidizing substances, aldehydes, phenols, alcohols, alkali salts, halogens, surfactants, etc., but all have shortcomings. An ideal disinfectant should have a broad bactericidal spectrum, strong bactericidal ability, fast action speed, good stability, low toxicity, corrosiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/47A61K31/4425A61K31/704A61P1/02A61P31/02A61P31/12A61P31/14A61P31/04A61P31/10A61P29/00A61P17/00A61K47/10A61K47/22A61K33/00A61K9/12
CPCA61K38/47C12Y302/01017A61K31/4425A61K31/704A61P1/02A61P31/02A61P31/12A61P31/14A61P31/04A61P31/10A61K33/00A61P29/00A61P17/00A61K47/10A61K47/22A61K9/12A61K9/006A61K9/0014Y02A50/30
Inventor 丁兴龙陈振欧兰香
Owner 山东莱博生物科技有限公司
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