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Adsorbent for removing protein binding uremic toxin through blood perfusion and preparation method thereof

A technology for blood perfusion and adsorbent, which is applied in the fields of blood circulation treatment, chemical instruments and methods, suction instruments, etc., to achieve the effects of good adsorption performance, reduced use of organic solvents, and good adsorption kinetics

Active Publication Date: 2021-05-14
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that although the above-mentioned products have achieved good clinical therapeutic effects, there is still room for improvement in the two aspects of continuing to improve the removal ability of PBUTs and removing middle molecular toxins at the same time.

Method used

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  • Adsorbent for removing protein binding uremic toxin through blood perfusion and preparation method thereof
  • Adsorbent for removing protein binding uremic toxin through blood perfusion and preparation method thereof
  • Adsorbent for removing protein binding uremic toxin through blood perfusion and preparation method thereof

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preparation example Construction

[0077] According to another aspect of the present invention, the present invention also relates to a method for preparing an adsorbent for removing protein-bound uremic toxins by hemoperfusion as described above, comprising the following steps:

[0078] (a) mixing the oil phase and the water phase for polymerization, and obtaining resin A after separation;

[0079] The oil phase includes styrene, acrylonitrile, divinylbenzene, porogen and benzoyl peroxide;

[0080] The aqueous phase comprises gelatin, sodium chloride and water;

[0081] (b) adding concentrated sulfuric acid to the resin A obtained in step (a) for hydrolysis to obtain resin B;

[0082] (c) Mix the ethanol solution of the imprinted molecules, the resin B, 1,2-dichloroethane, and anhydrous ferric chloride to perform a cross-linking-imprinting reaction to obtain a protein-bound uremic drug for hemoperfusion removal. Adsorbents for toxins.

[0083] The preparation method of the invention has simple steps, mild c...

Embodiment 1

[0135] A method for preparing an adsorbent for removing protein-bound uremic toxins by hemoperfusion, comprising the following steps:

[0136](a) Polymerization reaction: 15 mass parts of styrene, 15 mass parts of acrylonitrile, 70 mass parts of 80% divinylbenzene, 50 mass parts of toluene, 50 mass parts of n-octanol, 1.5 mass parts of Benzoyl oxide (BPO) is uniformly mixed and prepared into an oil phase, and dropped into a pre-prepared water phase containing 1% mass concentration of gelatin and 10% mass concentration of sodium chloride at 50°C, the mass of the water phase and the oil phase The ratio is 4:1; after mixing, let it stand for 10 minutes, start stirring, adjust the particle size to a suitable range, then raise the temperature to 90°C at a speed of 1°C / 2min, and keep it warm for 12h; stop the reaction, drain the polymerization mother liquor, and wash with water at 50°C Resin until the effluent is clear, ethanol extracts the porogen at room temperature and transfers ...

Embodiment 2

[0140] A method for preparing an adsorbent for removing protein-bound uremic toxins by hemoperfusion, comprising the following steps:

[0141] (a) Polymerization reaction: the styrene of 5 mass parts, the acrylonitrile of 5 mass parts, the 80% divinylbenzene of 90 mass parts, the toluene of 100 mass parts, the n-octanol of 50 mass parts, the BPO of 0.5 mass parts Mix them evenly to form an oil phase, and put them into a pre-prepared water phase containing 0.5% mass concentration of gelatin and 5% mass concentration of sodium chloride at 50°C, and the mass ratio of the water phase to the oil phase is 3:1; After mixing, let it stand for 10 minutes, start stirring, adjust the particle size to a suitable range, raise the temperature to 80°C at a rate of 1°C / 2min, and keep it warm for 10h; stop the reaction, drain the polymerization mother liquor, wash the resin with water at 50°C until the effluent is clear, Extract the porogen with ethanol at room temperature, transfer to the wat...

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Abstract

The invention relates to the technical field of chemical engineering and biological medicine, in particular to an adsorbent for removing protein binding uremic toxin through blood perfusion and a preparation method thereof. The adsorbent for removing the protein-bound uremic toxin through blood perfusion is porous resin which has an amide group and takes polystyrene-acrylonitrile-divinylbenzene as a skeleton, and the porous resin has imprinted holes of imprinted molecules; and the imprinting molecules include a protein-binding toxoid and / or an analog of a protein-binding toxoid. The adsorbent disclosed by the invention has a remarkable removal effect on protein binding toxoid such as indoxyl sulfate and p-cresol sulfate, also has a certain removal capability on middle-macromolecule and small-molecule substances such as beta 2-microglobulin, vitamin B12, creatinine and pentobarbital sodium, and is excellent in safety performance and mechanical strength.

Description

technical field [0001] The invention relates to the technical fields of chemical engineering and biomedicine, in particular to an adsorbent used for hemoperfusion to remove protein-bound uremic toxins and a preparation method thereof. Background technique [0002] Uremia is a clinical syndrome shared by various advanced chronic kidney disease (CKD), which refers to a series of clinical manifestations that appear when chronic renal failure caused by CKD enters the terminal stage. sign. Uremic toxins refer to a large group of metabolic products that accumulate in the blood and tissues and are toxic as the renal function declines and the renal clearance rate of solutes decreases. The European Uremic Toxin Working Group (EUTox) divides them into three categories according to their biochemical characteristics and clearance methods: 1. Water-soluble, small molecular substances that are not bound to proteins, and the molecular weight is usually less than 500, such as urea, creatin...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/28B01J20/30A61M1/36
CPCB01J20/268B01J20/28004B01J20/28011B01J20/28064B01J20/3057B01J20/3085A61M1/3621
Inventor 欧来良于浩峰
Owner NANKAI UNIV
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