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Medical water-based adhesive and using method thereof

A water-based, medical technology, applied in the field of medical adhesives and medical water-based adhesives, can solve the problems of lack of scientific evidence and inconvenient use

Active Publication Date: 2020-12-22
STOMATOLOGICAL HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chinese invention CN108421080A discloses the preparation method of giant salamander secretion hydrogel, which needs to apply external pressure in the process of preparing the gel. In vivo animal experiment effect
[0007] The above shows that the medical materials prepared from giant salamander skin mucus still have defects to be solved urgently

Method used

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  • Medical water-based adhesive and using method thereof
  • Medical water-based adhesive and using method thereof
  • Medical water-based adhesive and using method thereof

Examples

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preparation example Construction

[0026] Such as figure 1 As shown, the preparation method of the medical water-based adhesive provided by the present invention includes the following steps: step 1 obtains mucus from the skin of a living giant salamander, and freeze-dries the mucus; step 2 pulverizes the freeze-dried mucus in a frozen state to obtain a particle size Powder less than 1000 μm; Step 3: Sterilize the powder to obtain freeze-dried powder of giant salamander skin mucus; The weight ratio is mixed to form a medical water-based adhesive.

[0027] The method of collecting mucus in step 1 should be carried out in strict accordance with China's animal protection law, without killing the giant salamander and without causing permanent disability of the giant salamander. Scratching method or electrical stimulation method can be used, which is not limited in the present invention.

[0028] In step 2, the collected giant salamander skin mucus is freeze-dried, pulverized by a ball mill at a low temperature an...

Embodiment 1

[0033] Example 1: Preparation of medical water-based viscose and analysis of swelling rate

[0034] The preparation of the medical water-based adhesive of the present invention adopts the weight ratio of the freeze-dried powder of giant salamander skin mucus to the aqueous solution of 1:2 to 1:6, that is, 1 part of the freeze-dried powder of giant salamander skin mucus and 2 to 6 parts by weight of The medical water-based adhesive is obtained after the aqueous solution is mixed.

[0035] When the giant salamander skin mucus freeze-dried powder is mixed with an aqueous solution, the polypeptide cross-linked network expands rather than dissolves, and after mixing, the entangled protein network driven by hydrogen bonds in the giant salamander skin mucus freeze-dried powder is changed to form a gel. This process is called into glue. During the gelation process, the amino acid residues of the polypeptide chain undergo a conformational transformation to form a gel-like adhesive, an...

Embodiment 2

[0043] Embodiment 2: Structural analysis of medical water-based adhesive of the present invention

[0044] The medical water-based adhesive provided by the invention has a porous structure after being gelled, so that it can facilitate the exchange of nutrients and metabolites in interstitial fluid during clinical application.

[0045] Analyze the porous structure of the medical water-based adhesive obtained in Example 1 of the present invention with a scanning electron microscope (Hitachi, S-3400N II, Japan), as Figure 3A shown. The freeze-dried powder of giant salamander skin mucus formed after the freeze-drying of giant salamander skin mucus is a white powder, which is shown as uneven lumps by scanning electron microscope analysis. However, when the lyophilized powder of giant salamander skin mucus was mixed with an aqueous solution, the polypeptide chains in the clumps would expand and interpenetrate to form a medical water-based adhesive with a three-dimensional honeycom...

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Abstract

The invention provides medical water-based adhesive. The medical water-based adhesive provided by the invention is applied to adhesion of skin and tissues of surgical wound surfaces or other wounds byutilizing the characteristic that andrias davidianus blanchard mucus is made into freeze-dried powder and can generate strong adhesion performance after being mixed with various bioactive solvents. The medical water-based adhesive provided by the invention has good effects of being good in biological safety, capable of being degraded in vivo, and capable of promoting regeneration, also has antibacterial and hemostatic effects, is suitable for being used as a tissue adhesive or dressing for surgical wound surfaces or tissue injury parts, and is an ideal material for meeting the requirements for tissue wound repair and healing.

Description

technical field [0001] The invention belongs to the field of biological materials and relates to medical adhesives, in particular to a medical water-based adhesive prepared by using natural ingredients as raw materials and a method for using the same. Background technique [0002] Closing surgical wounds is an essential part of surgical treatment, and more than 60% of wounds are closed clinically with sutures and skin staples. However, the second visit to the doctor due to stitch removal not only increases the number of doctor visits, but also may cause scar hyperplasia, contracture, foreign body infection and other risks due to tension. The use of sutureless methods such as biomedical glue can simplify surgical procedures, shorten recovery times, and improve the quality of patient care. [0003] For difficult-to-heal wounds, deep wounds caused by puncture, and wounds that are difficult to bandage in wet environments, whether medical adhesives can be used to seal the wound ...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L26/00
CPCA61L24/0005A61L24/001A61L24/0015A61L24/0031A61L24/0036A61L26/0057A61L26/0061A61L26/0066A61L26/008A61L26/0085A61L2300/404A61L2300/412A61L2400/04
Inventor 张曦木
Owner STOMATOLOGICAL HOSPITAL OF CHONGQING MEDICAL UNIV
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