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4D deformed reticulated hollowed degradable vascular stent with concave-convex structures on inner and outer surfaces, preparation method and application method thereof

A technology with concave-convex structure and inner and outer surfaces, which is applied in the field of intelligent shape memory polymer materials and biomedical devices, can solve the problems of complex equipment, waste of materials, and complicated processes, so as to improve adherence, reduce thrombus formation, and enhance compatibility sexual effect

Pending Publication Date: 2020-08-28
LINYI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of this, the manufacture of shape memory polymer degradable scaffolds is still limited to weaving, laser processing and 3D printing. There are problems such as complex equipment, complicated process, time-consuming and waste of materials. At present, there is still a lack of a fast forming speed and material source Wide range, low production cost, simple synthesis method and process steps for the preparation of shape memory 4D deformable degradable vascular stents

Method used

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  • 4D deformed reticulated hollowed degradable vascular stent with concave-convex structures on inner and outer surfaces, preparation method and application method thereof
  • 4D deformed reticulated hollowed degradable vascular stent with concave-convex structures on inner and outer surfaces, preparation method and application method thereof
  • 4D deformed reticulated hollowed degradable vascular stent with concave-convex structures on inner and outer surfaces, preparation method and application method thereof

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Effect test

Embodiment 1

[0041] The present invention provides a method for preparing and using a 4D deformed mesh hollow degradable vascular stent with concave-convex structures on both inner and outer surfaces, comprising the following steps:

[0042] Step 1: Synthesizing the material of the degradable vascular stent, which is a thermosetting polymer containing dynamic covalent bonds or a thermoplastic polymer or thermosetting polymer containing further cross-linkable functional groups. This step belongs to the prior art and will not be repeated here.

[0043] Step 2: Laser cut the raw material film prepared in Step 1 into a paper-cut pattern with the desired structure.

[0044] Step 3: Heat the material with the cutting pattern in step 2 above the transition temperature, stretch the material, and after stretching to a certain strain, keep the external force, and reduce the temperature of the material below the transition temperature, and the inner and outer surfaces can be obtained in one step. Re...

Embodiment 2

[0049] Weigh 6 g of polycaprolactone diol (molecular weight 2000) and 1.26 g of hexamethylene isocyanate trimer (PHDI) and dissolve them in 20 ml of dichloromethane, add two drops of dibutyltin dilaurate, mix well, Pour it into a polytetrafluoroethylene mold, volatilize the solvent at 25 °C for 24 h, then heat it to 50 °C for vacuum drying, and continue to cure for 12 h. After the reaction, the polymer sheet with a thickness of 0.5 mm was demoulded. The shape memory transition temperature of the obtained polymer sheet is around 43 °C, as figure 2 As shown; the material contains a large number of ester bonds, at different temperatures, transesterification dynamic bonds (transesterification reaction mechanism such as image 3 shown) the time to complete the exchange is as Figure 4 As shown, in this embodiment, the molding temperature is selected as 140°C, and the molding time is 50 min.

[0050] The technical process of preparing the mesh hollow vascular stent with the polym...

Embodiment 3

[0053] Weigh 3 g polycaprolactone (molecular weight 1500), 1.2 g 1,4-butanediol, 10 g anhydrous N,N-dimethylformamide, two drops of dibutyltin dilaurate (DBTDL) and 5.2 g Isophorone diisocyanate was added to a dry three-necked flask. Under nitrogen protection, stir and react at 90°C for 4 h, after the reaction time ends, the temperature in the flask is cooled to 50°C, then add 1.65 g of acrylate-2-hydroxyethyl ester, and heat up to 80°C to continue the reaction for 4 h. After the reaction was completed, it was lowered to room temperature, 0.015g of photoinitiator UV184 was added, it was poured into a polytetrafluoroethylene mold, dried at 80°C for 2 h, then placed in a vacuum oven, and dried in vacuum at 80°C for 2 h. After cooling down to room temperature, the film was demolded to obtain a thermoplastic polycaprolactone-based shape-memory polyurethane sheet containing photocurable double bonds. The shape memory transition temperature (melting point) of the obtained polymer ...

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Abstract

The invention discloses a 4D deformed reticulated hollowed degradable vascular stent with concave-convex structures on the inner and outer surfaces, a preparation method and a use method thereof. A thermoplastic polymer containing a dynamic covalent bond, a thermosetting polymer containing a functional group capable of further crosslinking or a thermosetting polymer is used as a raw material, theraw material is cut or clipped to form a desired hollowed structure, the material is heated to more than or equal to the transition temperature and then stretched to obtain a reticulated hollowed pattern with concave-convex structures on the inner and outer surfaces, the raw material is rolled into a tubular shape and fixed, then bond exchange of the dynamic covalent bond is activated or the functional group is initiated for crosslinking, molding is finished, and a shape-permanent vascular stent product is obtained. The brand-new method for producing in-vivo stents provided by the invention has the characteristics of simple operation, high molding speed, simple process steps, no need of professional equipment and the like, and the integrated design of once molding of the complex stent shape, rapid manufacturing and 4D self-deformation function is realized.

Description

technical field [0001] The invention relates to a preparation method of a 4D deformed mesh hollow degradable vascular stent with concave-convex structures on both inner and outer surfaces and the resulting product, belonging to the field of intelligent shape memory polymer materials and biomedical devices. Background technique [0002] Cardiovascular disease has become the number one health killer worldwide. At present, the most effective treatment for this disease is balloon transluminal coronary angioplasty (PTCA), which uses stent materials to provide radial support for blood vessels to prevent restenosis, so as to achieve the purpose of treatment. At present, vascular stents have undergone three revolutionary developments, namely, the first-generation bare metal stents, the second-generation drug-eluting stents, and the third-generation biodegradable polymer stents. In recent years, it has been found that the most reliable method is to use a fully degradable stent, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C69/00B29C53/60B29C53/80B29C71/00A61F2/86
CPCA61F2/86A61F2210/0004A61F2210/0023B29C53/60B29C53/8008B29C69/001B29C71/0072B29L2031/753
Inventor 李兴建张静郑玉林杨继龙侯晴范宇飞
Owner LINYI UNIVERSITY
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