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Oxygen-microbubble-containing hydrogel for treating diabetic feet, and preparation method and purpose thereof

A diabetic foot and hydrogel technology, which is applied in the direction of microcapsules, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of oxygen-carrying preparations that have not been seen in the treatment of diabetic foot ulcers and gangrene Report and other issues, to achieve the effect of promoting microcirculation blood flow, preventing thrombus, and increasing blood oxygen concentration

Pending Publication Date: 2020-06-05
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there have been no reports of any oxygen-carrying preparations for the treatment of diabetic foot ulcers and gangrene

Method used

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  • Oxygen-microbubble-containing hydrogel for treating diabetic feet, and preparation method and purpose thereof
  • Oxygen-microbubble-containing hydrogel for treating diabetic feet, and preparation method and purpose thereof
  • Oxygen-microbubble-containing hydrogel for treating diabetic feet, and preparation method and purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0040] A preparation method of the hydrogel containing oxygen microbubbles for the treatment of diabetic foot comprises the following steps:

[0041] 1) placing the freeze-dried powder of phospholipid vitamin E composite membrane microbubbles in a vial filled with oxygen, and sealing;

[0042] 2) Dissolve the cell growth factor in water equal to the volume of the phospholipid vitamin E composite film microbubble freeze-dried powder to form a cell growth factor solution, inject it into the vial in step 1), shake it gently to form a phospholipid that wraps oxygen Vitamin E composite membrane microbubble solution;

[0043] 3) The heparin-poloxamer polymer is dissolved in water to form a heparin-poloxamer polymer gel, which is added to the phospholipid vitamin E composite membrane microbubble solution wrapped in oxygen in step 2) to form oxygen-containing microbubbles Hydrogels.

[0044] In one embodiment of the present invention, preferably, the heparin-poloxamer polymer in ste...

Embodiment 1

[0052] A hydrogel containing oxygen microbubbles for the treatment of diabetic foot

[0053] Experimental group 1-10: According to the composition of the hydrogel experimental group containing oxygen microbubbles in Table 1, measure each component, and prepare the hydrogel containing oxygen microbubbles according to the following method:

[0054] (1) Place the freeze-dried powder of phospholipid vitamin E composite film microbubbles in a vial full of high-purity oxygen, and seal it with a rubber stopper;

[0055] (2) The cell growth factor is dissolved in water equal to the volume of the phospholipid vitamin E composite membrane microbubble freeze-dried powder to form a cell growth factor solution, which is injected into the vial of (1), shaken gently to form a package high Pure oxygen phospholipid vitamin E composite film microbubble solution;

[0056] (3) The heparin-poloxamer polymer is dissolved with 2 times the volume of water to form a heparin-poloxamer polymer gel, whi...

Embodiment 2

[0067] Example 2 Animal Model Application Effect Evaluation of Hydrogel Containing Oxygen Microbubbles

[0068] (1) Diabetic foot ulcer and gangrene model animals

[0069] According to the literature, animal models of diabetic foot ulcer and gangrene were established. The method is briefly described as follows: select Wistar rats and induce diabetes with streptozotocin. From the second week of modeling, the rats were allowed to swim for 15 minutes every day, and the rats were placed on ice for 30 minutes. One week later, the skin of the hind limbs of the rats was cold and the color was dark purple. At the end of the second week, each hind limbs of the rats were frozen 3 times with liquid nitrogen cotton swabs, 2Os each time, and the next freezing was performed after the skin was rewarmed. Local congestion and edema of the hind limbs occurred after freezing with liquid nitrogen cotton swabs. The congested and edema area of ​​the hind limbs expanded on the 2nd day after freezin...

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Abstract

The invention discloses oxygen-microbubble-containing hydrogel for treating diabetic feet. The hydrogel comprises heparin-poloxamer polymer gel, cell growth factors and phospholipid vitamin E composite membrane microbubbles. The preparation method of the hydrogel disclosed by the invention comprises the following steps of (1) putting freeze-dry powder of the phospholipid vitamin E composite membrane microbubbles into a vial fully filled with oxygen, and performing sealing; (2) dissolving the cell growth factors to form a cell growth factor solution, and injecting the cell growth factor solution into the vial to form an oxygen coated phospholipid vitamin E composite membrane microbubble solution; and (3) dissolving heparin-poloxamer polymers by water to form the heparin-poloxamer polymer gel, and adding the heparin-poloxamer polymer gel into the microbubble solution in step (2) to form the oxygen-microbubble-containing hydrogel. The invention also discloses a purpose of the hydrogel toultrasonic gel preparation equipment and reagents.

Description

technical field [0001] The invention belongs to the technical field of medical equipment, and relates to a hydrogel containing oxygen microbubbles, in particular to a hydrogel containing oxygen microbubbles for treating diabetic feet, a preparation method and application thereof. Background technique [0002] Diabetes is a disorder of hyperglycemia due to insufficient secretion of insulin. About 15% of diabetic patients will develop diabetic foot disease in their lifetime, and diabetic foot disease has become the main cause of chronic skin wounds. Diabetic foot disease is extremely harmful, and severe cases can lead to amputation of toes, limbs, and even death. The treatment measures for diabetic foot disease mainly include: timely revascularization, pain relief, comprehensive treatment, hyperbaric oxygen therapy, stem cell therapy, etc. Among them, hyperbaric oxygen therapy can improve tissue hypoxia, enhance perfusion, improve edema, reduce inflammation, promote fibrobla...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K41/00A61K9/06A61K9/50A61K31/727A61K33/00A61K47/10A61K47/60A61K47/22A61K47/24A61P3/10A61P9/14A61P17/02A61K36/07A61K38/17
CPCA61K38/1866A61K38/18A61K33/00A61K31/727A61K41/0028A61K9/06A61K9/5015A61K47/10A61K47/60A61P3/10A61P9/14A61P17/02A61K36/07A61K38/1767A61K2300/00Y02A50/30
Inventor 鲁翠涛赵应征姚情徐荷林薛鹏鹏韩永辉翟媛媛
Owner WENZHOU MEDICAL UNIV
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