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Medicine carrying injectable implanted in-situ hydrogel

A hydrogel, in situ technology, used in anti-tumor drugs, drug combinations, drug delivery, etc., can solve the problems of slow speed and low gelation speed, and achieve increased residence time, less physical trauma, and tumor prevention. effect of recurrence

Inactive Publication Date: 2020-06-05
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these environmentally sensitive original gels change from liquid to gel at a slower rate, usually in a few minutes; when the volume is larger, the overall gelation rate may be smaller

Method used

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  • Medicine carrying injectable implanted in-situ hydrogel
  • Medicine carrying injectable implanted in-situ hydrogel
  • Medicine carrying injectable implanted in-situ hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1. Isoniazid injectable implantation in situ hydrogel

[0036] Dissolve 1 g of sodium hyaluronate with a molecular weight of 500 kDa in 100 mL of water, add an equimolar amount of sodium periodate, keep away from light, stir at room temperature for 2 h, then add 1 mL of ethylene glycol, continue stirring for 1 h, and dialyze the reaction solution with water for 3 h. Day, after freeze-drying to obtain aldylated hyaluronic acid, dissolved in phosphate buffer to obtain 20mg / mL aldylated hyaluronic acid, added 1g of isoniazid, stirred evenly as the aldylated precursor material, an equal volume of 20mg / mL carboxymethyl chitosan solution was used as the amination precursor material. After the two precursor materials were mixed, they were quickly injected into the cavity of the body to obtain isoniazid injectable implantable in situ hydrogel.

[0037] figure 1 is the synthetic route map of aldylated hyaluronic acid, figure 2 It is the H NMR spectrum of aldylated hy...

Embodiment 2

[0038] Example 2, moxifloxacin injectable implantation in situ hydrogel

[0039] Using EDC / NHS catalysis, one end of adipic acid dihydrazide and hyaluronic acid are connected through an amide bond, purified by dialysis and freeze-dried to obtain aminated hyaluronic acid as an aminated precursor material, which is prepared by sodium periodate oxidation method Aldehydated hyaluronic acid was obtained as the aldhylated precursor material, and the phosphate buffer solution of the above-mentioned concentration of 20 mg / mL aldylated hyaluronic acid and aminated hyaluronic acid was mixed in equal volumes, and moxifloxacin was added , to obtain a mixed solution containing 10 mg / mL moxifloxacin, and quickly inject it into the cavity of the body to obtain an injectable implantable in situ hydrogel of moxifloxacin.

Embodiment 3

[0040] Example 3, Paclitaxel injectable implantation in situ hydrogel

[0041] Prepare aldylated sodium alginate by sodium periodate oxidation method as the aldylated precursor material, lyophilize after dialysis purification, add phosphate buffer to prepare a 30mg / mL alginated sodium alginate solution, add paclitaxel and stir Uniformly, the alginate sodium alginate solution containing 10mg / mL paclitaxel is obtained, and an equal volume of 20mg / mL carboxyethyl chitosan phosphate buffer solution is injected into the body cavity simultaneously with two syringes to obtain paclitaxel. Injection implanted in situ hydrogel.

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Abstract

The invention discloses a medicine carrying injectable implanted in-situ hydrogel which is characterized by being formed at an injection part in situ on the basis of a Schiff base reaction in a chemical bond cross-linking mode, and the hydrogel has self adaptability to the shape of an injection cavity, and is long in retention time in the cavity, and medicines are in controlled release. The hydrogel is used for filling of cavities after a tumor operation, the cavities can be rapidly filled through flowability of the in-situ hydrogel, the hydrogel can be in close contact with edge tissue aftertumor excision, residual tumor cells can be well eliminated, and a remarkable effect of preventing tumor recurrence can be achieved.

Description

technical field [0001] The invention relates to the field of medical implant preparations, in particular to drug-loaded injectable implantable in situ hydrogels. Background technique [0002] Cancer (malignant tumor) is a major disease that seriously threatens human health, with high morbidity and mortality. Currently, the commonly used clinical treatment methods mainly include surgery, chemotherapy and radiotherapy. Depending on tumor size and pathological stage, surgery is often used as the first-line treatment. After tumor surgical resection, the in situ recurrence and metastasis rate of the tumor is high, and about 70% of the patients eventually fail to treat due to recurrence and metastasis. Therefore, postoperative radiotherapy, chemotherapy and other methods are often used to suppress tumor recurrence and metastasis. Radiation therapy and systemic chemotherapy generally cause serious side effects and reduce the quality of life of patients. Therefore, there is a nee...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/36A61K47/61A61K31/704A61K31/7068A61P35/00
CPCA61K9/06A61K9/0024A61K47/36A61K47/61A61K31/704A61K31/7068A61P35/00A61K2300/00
Inventor 金义光庄波杜丽娜
Owner ACADEMY OF MILITARY MEDICAL SCI
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