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Argy wormwood leaf volatile oil soft capsule for assisting treatment of bronchial asthma and therapy by using soft capsule

A technology for bronchial asthma and volatile oil of mugwort leaves, which is applied in the directions of capsule delivery, non-active ingredients of oil/fat/wax, and medical preparations containing active ingredients, etc. problem, to achieve the effect of low value, abundant argyi leaf resources, and small dosage

Inactive Publication Date: 2020-05-08
YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Artemisia argyi volatile oil is easy to volatilize, and is easily affected by the outside world to change its composition. In general preparations, its properties are unstable, it is not easy to dissolve in water, and the concentration of the aqueous solution is low, which reduces the efficacy.

Method used

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  • Argy wormwood leaf volatile oil soft capsule for assisting treatment of bronchial asthma and therapy by using soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Extraction of volatile oil from leaves of Artemisia argyi

[0031] A kind of Artemisia argyi volatile oil soft capsule for auxiliary treatment of bronchial asthma and its therapy. The wormwood volatile oil is extracted by steam distillation, and the steps are as follows: Weigh 200g of dried Artemisia argyi leaves, put them in a round bottom flask, add 2000ml of distilled water, connect the volatile oil Add water from the upper end of the condenser tube to the tester and the reflux condenser tube to fill the scaled part of the volatile oil tester until it overflows into the flask, soak for 12 hours, put it in an electric heating mantle for reflux heating and extraction for 5 hours, stop heating, open the piston at the lower end of the tester, and The water was released slowly, and the volatile oil was collected and weighed. The extraction rate of the volatile oil from Artemisia argyi leaves was 0.60% (w / w).

[0032] 2. Preparation of Artemisia argyi Volatile Oil Soft ...

Embodiment 2

[0039] Example 2 In vitro bacteriostasis of Artemisia argyi volatile oil

[0040] 1.1 Materials

[0041] Tested species: Escherichia coli, Salmonella, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus.

[0042] 1.2 Method

[0043] Using the cup and saucer method and the double-layer plate method, the inhibitory effect of the volatile oil from Artemisia argyi leaves in soft capsules on the growth of the tested bacteria was determined. Invert the bottom plate first, then absorb 10 mL of the prepared bacterial solution, and mix it into 90 mL of culture medium cooled to about 45 °C, so that the final concentration of the bacterial solution is 10 6 ~10 7 cfu / mL to prepare the upper plate with bacteria. After solidification, place a sterile Oxford cup symmetrically on the plate, add 100 μL of Artemisia argyi volatile oil taken from the soft capsule of Example 1 into the Oxford cup, and carry out three parallel experiments, using sterile water as a blank control. Incu...

Embodiment 3

[0049] Example 3 Anti-inflammatory effect of Artemisia argyi volatile oil

[0050] 1.1 Experimental grouping

[0051] Blank control group: 0.5% Tween-80 saline, orally administered at a dose of 20ml / kg.

[0052] Dosing group: Take Artemisia argyi volatile oil soft capsules prepared in Example 1, take out the contents of the soft capsules, and administer them by intragastric administration at a low dose of 1 ml / kg and a high dose of 3 ml / kg.

[0053] Positive control group: dexamethasone, administered orally at a dose of 5 mg / kg.

[0054] 1.2 Method

[0055] Take 40 mice weighing 25.0±1.0 g, half male and half male, 10 mice in each group. On the basis of normal feeding, the blank control group was given intragastric administration of 0.5% Tween-80 normal saline (20ml / kg), and the treatment group was given intragastric administration once a day (low dose 1ml / kg, high dose 3ml / kg). The positive control group was administered dexamethasone (5 mg / kg) for 5 consecutive days. On...

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Abstract

The invention discloses an argy wormwood leaf volatile oil soft capsule for assisting treatment of bronchial asthma and a therapy by using the soft capsule. The soft capsule uses argy wormwood leaf volatile oil as a medicinal component, the argy wormwood leaf volatile oil is prepared in the form of a soft capsule dosage, an electronic heater is used as a drug delivery tool, the mechanical structure of the heater is used to destroy the soft capsule, the argy wormwood leaf volatile oil contained in the soft capsule is slowly released, the volatile oil is vaporized through the electrical heatingmanner and is inhaled into a respiratory tract through a mouth and nose, and medicinal molecules directly reach trachea, bronchus and lung and other lesions to realize quick positioning and play a role; the argy wormwood leaf volatile oil has antitussive antiasthmatic anti-inflammatory and antibacterial effects; and the therapy has an obvious quick-acting effect and positioning effect as a targeted drug delivery method, and can obviously relieve the symptom of the bronchial asthma, effectively reduce the dose of hormone drugs in traditional treatment, and reduce the side effects.

Description

technical field [0001] The invention belongs to the field of natural medicines, and in particular relates to a soft capsule of Artemisia argyi volatile oil for auxiliary treatment of bronchial asthma and its therapy. Background technique [0002] The English name "asthma" of bronchial asthma (bronchial asthma, referred to as asthma) originated from the ancient Greek word "aazein", which means "short breathing". Asthma is a heterogeneous disease characterized primarily by chronic airway inflammation and includes a history of changing respiratory symptoms over time, such as wheezing, shortness of breath, chest tightness, coughing, and variable expiratory airflow limitation, which It often recurs, lasts for a long time, and may cause severe damage to lung function. Symptoms of asthma include wheezing, chest tightness, shortness of breath and coughing, etc. The time and degree of attacks vary from person to person. The patient's asthma symptom control level directly affects th...

Claims

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Application Information

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IPC IPC(8): A61K36/282A61K9/48A61K47/44A61P11/06A61P11/10A61P11/14
CPCA61K9/007A61K9/4825A61K9/4858A61K36/282A61K2236/331A61P11/06A61P11/10A61P11/14
Inventor 刘胜贵王钲霖薛红芬付彬彬李智高孔令羽
Owner YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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