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Polymeric microsphere with disaccharide-based skeleton and preparation method of polymeric microsphere

A technology of polymerizing microspheres and disaccharide groups, which is applied in the preparation of microspheres, microcapsule preparations, surgical adhesives, etc., can solve the problems of high swelling and poor biocompatibility of microspheres, and achieve good sphericity and smooth surface , The effect of simplifying the process

Active Publication Date: 2020-04-28
GUANGZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the problems of poor biocompatibility and high swelling of microspheres, and provide a polymeric microsphere with a disaccharide-based skeleton. The microspheres have excellent biocompatibility and swelling properties of 1.5 to 2 times aggregated microspheres

Method used

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  • Polymeric microsphere with disaccharide-based skeleton and preparation method of polymeric microsphere
  • Polymeric microsphere with disaccharide-based skeleton and preparation method of polymeric microsphere
  • Polymeric microsphere with disaccharide-based skeleton and preparation method of polymeric microsphere

Examples

Experimental program
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Effect test

Embodiment 1

[0046] Add 5 g of maltose (equivalent to 1 part of maltose) into a three-neck flask filled with 25 ml of pure water, stir and disperse evenly. Then add 5.302g of bromopropene (equivalent to 3 parts of bromopropene), adjust the pH to 11, and after magnetic stirring for 15min, 0.050g of tetrabutylammonium perchlorate (equivalent to 0.01 part of tetrabutylammonium perchlorate) Add to the reaction solution. The mixed solution was heated to 75° C., and the reaction was continued to stir for 24 hours. After extraction, it was washed and dried, and purified by chromatographic column to obtain allyl digose ether.

[0047] Prepare the molar ratio of photoinitiator HMPP and allyl disaccharide ether respectively as 7.43%, 13.15%, 18.98%, 21.38% and 36.50% of the mixture, evenly spread on the dried potassium bromide sheet, use Fourier transform Kinetic curves of photopolymerization were obtained by real-time infrared (RT-IR).

[0048] figure 1 is the cross-linked structure of microsphe...

Embodiment 2

[0050] Add 5 g of sucrose (equivalent to 1 part of sucrose) into a three-neck flask filled with 15 ml of pure water, stir and disperse evenly. Then add 3.535g of bromopropene (equivalent to 2 parts of bromopropene), adjust the pH to 9, and after magnetic stirring for 15min, mix 0.050g of tetrabutylammonium perchlorate (equivalent to 0.01 part of tetrabutylammonium perchlorate) Add to the reaction solution. The mixed solution was heated to 75° C., and the reaction was continued to stir for 24 hours. After extraction, it was washed and dried, and purified by chromatographic column to obtain allyl digose ether.

[0051] Prepare the molar ratio of photoinitiator 127 and allyl digose ether respectively as 2.96%, 4.72%, 7.68%, 10.49%, 14.91% and 22.14% of the mixture, evenly spread on the dried potassium bromide sheet, use Fu Kinetic curves of photopolymerization were obtained by Leaf transform real-time infrared (RT-IR). like image 3 As shown, the conversion rate of allyl disac...

Embodiment 3

[0053] Add 5 g of kojibiose (equivalent to 1 part of kojibiose) into a three-neck flask filled with 25 ml of pure water, stir and disperse evenly. Then add 5.291g of methyl chloride propene (equivalent to 4 parts of methyl chloride propene), adjust the pH to 9, and after magnetically stirring for 15 minutes, add 0.050 g of tetrabutylammonium perchlorate (equivalent to 0.02 parts of tetrabutyl perchlorate ammonium chlorate) was added to the reaction solution. The mixed solution was heated to 75° C., and the reaction was continued to stir for 24 hours. After extraction, it was washed and dried, and purified by chromatographic column to obtain allyl digose ether.

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Abstract

The invention provides a polymeric microsphere with a disaccharide-based skeleton and a preparation method of the polymeric microsphere. The polymeric microsphere is prepared by the following steps of: irradiating allyl disaccharide ether and a photoinitiator; the chemical formula of the allyl disaccharide ether is shown as a formula (I) or a formula (II), wherein R1, R2, R3, R4, R5, R6, R7 and R8are hydrogen or alkenyl groups which are independent from one another, the alkenyl groups are allyl groups and / or methyl allyl groups, the number of the alkenyl groups is 2-8, and the functional group molar ratio of the photoinitiator to the allyl disaccharide ether is 6-46: 100. The invention also provides the preparation method of the polymeric microsphere with the disaccharide-based skeleton.The microsphere has the functional characteristics of excellent biocompatibility and dispersity, and the preparation method is green and environment-friendly, can be carried out at low temperature, ishigh in conversion rate, and provides feasibility for large-batch industrial production.

Description

technical field [0001] The present invention relates to organic macromolecular compounds, more specifically, to a disaccharide-based polymeric microsphere and a preparation method thereof. Background technique [0002] Modern medicine uses interventional embolization to treat patients with advanced tumors. It has many advantages such as good targeting, minor trauma, and low complications. The embolic material used is microspheres. [0003] Chinese patent, application number 201510456136.8 "A preparation method of polysaccharide-polyvinyl alcohol embolic microspheres" The polysaccharide-polyvinyl alcohol embolic microspheres are elastic microspheres made of polyvinyl alcohol and polysaccharide natural polymers blended and crosslinked. ball. The polysaccharide-polyvinyl alcohol embolic microspheres have great flexibility and elasticity, are convenient for microcatheter delivery, and have a simple preparation method; at the same time, the embolization cycle can be controlled...

Claims

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Application Information

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IPC IPC(8): C08F116/14C08F2/48A61L24/00A61L24/06B01J13/18
CPCA61L24/001A61L24/0042A61L24/06B01J13/18C08F2/48C08F116/14
Inventor 叶国东赵笑天黄婉秋
Owner GUANGZHOU MEDICAL UNIV
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