Application of composition to preparation of medicine for inhibiting inflammatory response or promoting skin cutin metabolism

Abstract

The invention relates to the field of medicines, in particular to application of a composition to preparation of a medicine for inhibiting inflammatory response or promoting skin cutin metabolism. Theinvention provides a pharmaceutical composition containing an effective dose of 1-methyl-4-(prop-1-ene-2-yl) cyclohexyl-1-ene, R, R', R''-tetramethyl-1, 3, 5, 5'-tetramethyl-1, 3', 5, 5'-tetramethyl-1, 3', 5, 5'-tetramethyl-1, 3'-pentanedione. 3R, 4S, the preparation method comprises the following steps: adding 5-(hydroxymethyl) oxacyclopentane-3, 5, 6, 7, 8-tetrahydro-4H-purine-9-yl)-5-(hydroxymethyl) oxacyclopentane-2-(6-amino-9H-purine-9-yl)-5-(hydroxymethyl) oxacyclopentane-3, 5, 8, 10-tetracarboxylic acid; the invention discloses application of a composition containing 2, 4-diol, p-hydroxybenzoic acid, (2E)-3-phenylpropyl-2-enoic acid or a mixture thereof in preparation of a medicine for inhibiting inflammatory reaction and promoting skin keratinometabolism, and the composition can effectively inhibit keratinocytes from secreting inflammatory factors and promote keratinocyte proliferation.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the use of a composition for preparing medicines for inhibiting inflammation or promoting skin keratin metabolism. Background technique [0002] The stratum corneum is located in the outermost layer of the skin epidermis. Its main function is to keep the skin water and help the skin resist various environmental damages. The stratum corneum is composed of 15 to 20 layers of keratinocytes. Keratinocytes are dead cells without nuclei and organelles. The main component of keratin is keratin, which can absorb water and keep the skin moist. Keratinocytes will fall off by themselves after a period of time, and then the cells below the stratum corneum will be keratinized and pushed upward to form a new stratum corneum. [0003] The old waste cells in the stratum corneum will fall off by themselves under normal circumstances, but often due to environmental factors, the old waste corneocytes will...

AI Technical Summary

Problems solved by technology

In order to restore keratin metabolism to normal, there are currently many exfoliating ingredients and methods on the market. However, after artificial exfoliation, although the skin will become smooth and shiny, the skin will become fragile due to the thinning of the stratum corneum , Sensitive and decreased water retention capacity

[0004] In addition, UVB in ultraviolet light has high energy, which can penetrate into the epidermis of the skin and cause sunburn, and cause symptoms such as hypertrophy of the epidermis, thickening of the stratum corneum, redness, swelling and inflammation, and once the skin is severely sunburned, the skin in the area will recover , will also become more fragile and prone to spots due to damage

[0005] In order to improve the current treatment methods for poor metabolism of old waste keratinocytes; skin redness, inflammation, and thickening of the stratum corneum after ultraviolet light irradiation; and thinning and damage of the stratum corneum, resulting in fragile, sensitive and rough skin, a There is a real need for a medicinal composition that promotes natural skin rejuvenation that can promote keratinocyte metabolism, resist skin inflammation, and increase skin protection

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