Method for preparing quick-response temperature-sensitive hydrogel by adopting room-temperature eutectic solvent liquid frontal polymerization

Abstract

The invention discloses a method for preparing a quick-response temperature-sensitive hydrogel by adopting room-temperature eutectic solvent liquid frontal polymerization, and belongs to the technicalfield of preparation of functional polymer materials. The method comprises the following steps: mixing a polymerizable temperature-sensitive monomer, a hydrogen bond donor compound and a hydrogen bond acceptor compound, stirring at 80-100 DEG C until a transparent and clear liquid is formed, and cooling to room temperature to obtain a room-temperature eutectic solvent liquid; adding a cross-linking agent and an initiator into the room-temperature eutectic solvent liquid to form a mixture solution; transferring the formed mixture solution into a tubular reactor, initiating a reaction at the upper end or the lower end of the reactor by adopting a heat source or ultraviolet light, and removing the heat source or the ultraviolet light after the thermal initiation reaction is started until allthe raw materials in the whole reactor are converted into a polymer gel; and soaking and washing the obtained polymer gel with distilled water, and freeze-drying to obtain the target hydrogel. No extra liquid solvent is needed, the polymerization speed is high, the reaction time is short, and the energy consumption is low.

Description

technical field [0001] The invention specifically relates to a method for preparing rapid-response temperature-sensitive hydrogel by front-end polymerization of a room-temperature deep eutectic solvent liquid, and belongs to the technical field of preparation of functional polymer materials. Background technique [0002] Smart hydrogel is a hydrophilic polymer that can significantly swell in water but does not dissolve. It can change its structure and energy with changes in external fields such as temperature, pH value, enzymes, electric fields, light or ultrasound. . The outstanding feature of this type of hydrogel is the remarkable swelling response behavior during the change process. For this behavior of polymers, Flory and Stockmayer had already noticed it at the earliest. Tanaka first discovered the volume phase transition phenomenon of gels in the late 1970s and deduced the gel state equation, and proposed the theory of gel volume phase transitions. Since then, smart...

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Problems solved by technology

[0005] Aiming at the problems in the prior art, the present invention provides a method for preparing a rapid response temperature-sensitive hydrogel by front-end polymerization of a room-temperature deep eutectic solvent. In the method, a polymerizable temperature-sensitive monomer, a hydrogen bond donor compound and The hydrogen bond acceptor compounds are mixed and heated to obtain a stable non-toxic room temperature deep eutectic solvent liquid, and then the room temperature deep eutectic solvent liquid is used as the monomer and medium for front-end polymerization to carry out front-end polymerization to synthesize a temperature-sensitive hydrogel. The present invention The method can stably carry out front-end polymerization without using additional liquid solvent for dissolution, which can avoid the use of high-boiling point toxic organic solvent dimethyl sulfoxide, accelerate the polymerization rate of front-end polymerization, shorten the reaction time of front-end polymerization, and reduce production energy consumption , can solve the problem of using toxic high-boiling point dimethyl sulfoxide organic solvent system as the medium front-end polymerization to prepare temperature-sensitive hydrogel in the prior art, the polymerization speed is slow, the pollution of dimethyl sulfoxide to the environment is large, and it is very It is easy to remain in the polymer gel product, not easy to remove, and has the disadvantage of affecting the purity of the product

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