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An enhanced azo-salen Schiff base fluorescent probe, its synthesis and application

A fluorescent probe, enhanced technology, applied in the field of fluorescent probes, can solve the problems of large slope changes of curves, great influence on reagent purity, long reaction time, etc., achieve low detection limit, easy control of reaction conditions, and simple synthesis method Effect

Active Publication Date: 2021-05-04
HEZE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Traditional detection of Al 3+ The catechol ultraviolet spectrophotometry method of content has the disadvantages of tedious operation, large change of curve slope, and the method is greatly affected by the purity of reagents during use, while the other two methods also have shortcomings such as too long reaction time and inconvenient operation. Therefore, a sensitive and accurate selective determination of Al 3+ method, which has extremely important practical significance

Method used

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  • An enhanced azo-salen Schiff base fluorescent probe, its synthesis and application
  • An enhanced azo-salen Schiff base fluorescent probe, its synthesis and application
  • An enhanced azo-salen Schiff base fluorescent probe, its synthesis and application

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Example 1 Preparation and Characterization of Enhanced Azo-Salen Schiff Base Fluorescent Probe

[0038] Synthetic azo compounds:

[0039] Dissolve 1.5318g (10mmol) of 3,4-dimethoxyaniline and 2mL of concentrated hydrochloric acid in a 100mL round bottom flask with 15mL of distilled water, and then weigh sodium nitrite (NaNO 2 ) 2.4835g (12mmol), stir well and control the temperature at 0-5°C, and react for 30 minutes.

[0040] Add 1.7218 g (10 mmol) of 2-hydroxyl-1-naphthaldehyde in ethanol solution dropwise to the above solution, stir for 3 hours, add sodium carbonate (Na 2 CO 3 ) aqueous solution to adjust the pH to 7-8, let stand, filter with suction, and recrystallize from absolute ethanol to obtain 16 g of yellow solid powder, yield: 81.26%.

[0041] Synthetic fluorescent probes:

[0042] Dissolve 2.6989 g (8 mmol) of the yellow solid and 0.3606 g (4 mmol) of dihydrazide carbonate in absolute ethanol, add 2 to 3 drops of concentrated phosphoric acid, and stir a...

Embodiment 2

[0051] Embodiment 2 Enhanced azo-Salen Schiff base fluorescent probe detection method for metal ions

[0052] Mix various metal salts (aluminum nitrate, cobalt chloride, zinc acetate, lead nitrate, manganese acetate, ferric chloride, magnesium sulfate, cadmium sulfate, copper nitrate, chromium chloride, high mercury chloride, nickel nitrate) into 1×10 -4 mol / L aqueous solution. The enhanced azo-Salen Schiff base fluorescent probe was dissolved in acetonitrile to make 5×10 -4 mol / L standard solution. The method for measuring the fluorescence intensity of metal ions on the enhanced azo-Salen Schiff base fluorescent probe: add 0.1 mL of enhanced azo-Salen Schiff base standard solution and 5 mL of acetonitrile into the colorimetric tube, then add various metal ions respectively, and set Make up to 10mL, and measure the fluorescence intensity after 3 hours of reaction. The fluorescence excitation wavelength is 440nm, and the slit width is 10nm / 10nm.

Embodiment 3

[0053] Embodiment 3 Enhanced azo-Salen Schiff base fluorescent probe pair Al 3+ selective identification of

[0054] In order to investigate the effect of the enhanced azo-Salen Schiff base fluorescent probe on Al 3+ The selectivity of different metal ions (Al 3+ 、Co 2+ , Zn 2+ , Pb 2 , Mn 2+ , Fe 3+ , Mg 2+ 、Cd 2+ 、Cu 2+ 、Cr 3+ , Hg 2+ 、Ni 2+ ) in the presence of enhanced azo-Salen Schiff base fluorescence probe fluorescence emission spectrum (metal ion concentration is 1×10 -5 mol / L), see Figure 4 .

[0055] Depend on Figure 4 It can be seen that when Co 2+ , Zn 2+ , Pb 2 , Mn 2+ , Fe 3+ , Mg 2+ 、Cd 2+ 、Cu 2+ 、Cr 3+ , Hg 2+ 、Ni 2+ , the fluorescence intensity of the system has no obvious change, when adding Al 3+ After that, the fluorescence intensity of the system is greatly enhanced, which shows that the azo-Salen Schiff base has a strong effect on Al 3+ Produced a clear fluorescent response and good selective recognition, which can be used as...

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Abstract

The invention discloses an enhanced azo-Salen Schiff base fluorescent probe, its synthesis and application, and belongs to the technical field of fluorescent probes. The chemical formula of the fluorescent probe of the present invention is C 39 h 34 N 8 o 7 , the structural formula is: the fluorescent probe of the present invention is paired with Al 3+ It has good selectivity, good linear relationship, high sensitivity, strong fluorescence response, low detection limit and low cost, and can be widely used in the detection of Al in the environment 3+ ion. It can provide twice as many coordination sites, and it is easier to combine with Al 3+ After coordination, a dinuclear complex with multiple coordination sites is formed. After coordination, the rigidity of the molecular plane is enhanced, and the photoinduced electron transfer effect of the Schiff base nitrogen atom is suppressed, resulting in a strong chelating fluorescence enhancement effect. Moreover, the synthesis method is simple, the yield is high, and the reaction conditions are easy to control.

Description

technical field [0001] The invention relates to the technical field of fluorescent probes, in particular to an enhanced azo-Salen Schiff base fluorescent probe, its synthesis and application. Background technique [0002] Aluminum is the most abundant metallic element in the earth's crust and exists as ions in most biological tissues. Aluminum is a metal with a wide range of uses in life, but at the same time it is one of the metal elements that are extremely harmful to human health. For some essential elements to maintain human physiological activities, such as magnesium, calcium, iron, etc., because aluminum elements have similar atomic radii and similar valence states, aluminum ions can be used as a competitive inhibitor in biological processes, thereby Affect the normal physiological activities of the human body. With the aggravation of environmental pollution, especially the increase of acid rain, Al in soil and water 3+ The concentration gradually increases, which h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C245/08C09K11/06G01N21/64
CPCC07C245/08C09K11/06C09K2211/1003C09K2211/1007C09K2211/1011G01N21/643G01N2021/6421G01N2021/6432
Inventor 庞艳玲武利顺孟德素汪涛卢金凤
Owner HEZE UNIV
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