Scar anti-pruritic softening emulsifiable paste and preparation method thereof

A scar and cream technology, applied in the field of traditional Chinese medicine cream, can solve the problems of high storage conditions, easy to break oil and water, product deterioration, etc., to achieve the effect of optimizing the preparation process and improving stability

Inactive Publication Date: 2020-02-04
SICHUAN DEFENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the scar relieving and softening creams sold in the market have higher requirements for storage conditions, and the products are prone to demulsification and oil-water separation at higher temperatures, resulting in product deterioration and affecting the final therapeutic effect. Therefore, it is necessary to provide a new Technical solutions to solve the above problems

Method used

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  • Scar anti-pruritic softening emulsifiable paste and preparation method thereof
  • Scar anti-pruritic softening emulsifiable paste and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1.1 Extraction of Compound Galla Extract

[0029] Weigh gallnut 85.7g, Clematis 85.7g, Moutan cortex 42.9g, Eupatorium 42.9g, grind into fine powder, reflux and extract with 90% ethanol three times, add 6 times of solvent each time, reflux for 1 hour each time, filter After that, the filtrates were combined, the ethanol was recovered, concentrated to 120g, and the compound Galla gall extract was obtained.

[0030] 1.2 Preparation of scar antipruritic softening cream

[0031] (1) Weigh 110g of stearic acid, 20g of lanolin, 273g of petrolatum, 20g of liquid paraffin, 80g of Span 60, 50g of magnesium stearate, 43g of borneol, 34g of camphor, and 34g of menthol, stir and melt at 85°C to form an oil phase , heat preservation spare;

[0032] (2) Weigh 50g of glycerin, 100g of Tween 80, 1g of ethylparaben, 1g of propylparaben, 120g of extract, 38g of purified water, stir and dissolve at 85°C to form the water phase, and keep it warm for later use;

[0033] (3) Slowly add th...

Embodiment 2

[0036] 2.1 Extraction of Compound Galla Extract

[0037] Weigh gallnut 85.7g, Clematis 85.7g, Moutan cortex 42.9g, Eupatorium 42.9g, grind into fine powder, reflux and extract with 90% ethanol three times, add 6 times of solvent each time, reflux for 1 hour each time, filter After that, the filtrates were combined, the ethanol was recovered, concentrated to 120g, and the compound Galla gall extract was obtained.

[0038] 2.2 Preparation of scar antipruritic softening cream

[0039] (1) Weigh 170g of stearic acid, 20g of lanolin, 273g of vaseline, 20g of liquid paraffin, and 130g of Span 60, stir and melt at 85°C-90°C as the oil phase, and keep it warm for later use;

[0040] (2) Weigh 50g of glycerin, 28g of triethanolamine, 1g of ethylparaben, 1g of propylparaben, 120g of compound gallica extract, 50g of purified water, stir and dissolve at 85°C-90°C, use it as the water phase, and keep it warm for later use;

[0041] (3) Slowly add the water phase to the oil phase under st...

Embodiment 3

[0044] 3.1 Extraction of Compound Galla Extract

[0045] Weigh gallnut 85.7g, Clematis 85.7g, Moutan cortex 42.9g, Eupatorium 42.9g, grind into fine powder, reflux and extract with 90% ethanol three times, add 6 times of solvent each time, reflux for 1 hour each time, filter After that, the filtrates were combined, the ethanol was recovered, concentrated to 120g, and the compound Galla gall extract was obtained.

[0046] 3.2 Preparation of scar antipruritic softening cream

[0047] (1) Weigh 110g of stearic acid, 20g of lanolin, 273g of vaseline, 20g of liquid paraffin, 130g of Span 60, and 21.5g of borneol, stir and melt at 85°C, use it as the oil phase, and keep it warm for later use;

[0048] (2) Weigh 50g of glycerin, 28g of triethanolamine, 1g of ethylparaben, 1g of propylparaben, 120g of extract, and 110g of purified water, stir and dissolve at 85°C to form the water phase, and keep it warm for later use;

[0049] (3) Slowly add the water phase to the oil phase under s...

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Abstract

The invention relates to a scar anti-pruritic softening emulsifiable paste and a preparation method thereof. The paste contains the following substances: compound gallnut extractum, menthol, camphor,borneol, methyl salicylate, stearic acid, lanolin, vaseline, liquid paraffin, sorbitan monostearate, magnesium stearate, glycerin, Tween 80, ethyl hydroxybenzoate, propyl 4-hydroxybenzoate and distilled water. Compared with the prior art, the matrix formula and ratio of the paste are changed, and the preparation process is optimized, so that the stability of products is significantly improved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine cream. Background technique [0002] Pathological scars are caused by trauma, etc., and are characterized by the excessive production and deposition of a large amount of connective tissue matrix such as collagen. It is a unique fibrous metabolic disease in the human dermis, mainly including hypertrophic scars and keloids. The histological features of pathological scars are the proliferation of a large number of fibroblasts, excessive deposition of collagen, proteoglycan, and glycoprotein in the extracellular matrix, and disordered arrangement of collagen fibers (Jing Yasha, Liu Gang, Chinese Journal of Integrated Traditional Chinese and Western Medicine Dermatology, 2009, 8(4), 262-265). Hypertrophic scars are mainly due to the long-term continuous progress of collagen synthesis and metabolism, exceeding the speed of catabolism, resulting in the formation of a large number of collagen fibers. Co...

Claims

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Application Information

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IPC IPC(8): A61K36/716A61K9/107A61P17/02A61P17/04A61K35/64A61K31/045A61K31/125A61K31/618
CPCA61K9/107A61K31/045A61K31/125A61K31/618A61K35/64A61K36/53A61K36/65A61K36/71A61K36/716A61K47/44A61K2236/333A61K2236/39A61K2236/51A61P17/02A61P17/04A61K2300/00
Inventor 不公告发明人
Owner SICHUAN DEFENG PHARMA CO LTD
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