Method for improving taste of compound polyethylene glycol electrolyte powder

Abstract

The invention discloses an improving agent for improving the taste of a compound polyethylene glycol electrolyte powder oral solution, and a preparation method. The compound polyethylene glycol electrolyte powder is characterized in that active ingredients comprise 1 part of polyethylene glycol 4000, 0.05-0.12 part of anhydrous sodium sulfate, 0.01-0.05 part of sodium bicarbonate, 0.01-0.06 part of sodium chloride, 0.007-0.028 part of potassium chloride, and 0.001-0.004 part of saccharin sodium. The preparation method of the compound polyethylene glycol electrolyte powder is as follows: respectively crushing and sieving anhydrous sodium sulfate, sodium bicarbonate, sodium chloride, potassium chloride, and sodium saccharin; then weighing a prescription amount of polyethylene glycol 4000, anhydrous sodium sulfate, sodium bicarbonate, sodium chloride, potassium chloride and sodium saccharin for standby application; putting the above-mentioned materials for standby application into a mixerfor mixing, performing sampling and testing an intermediate content; and calculating a filling amount based on the intermediate content, performing sub-packing, and performing sealing to obtain the compound polyethylene glycol electrolyte powder.

Description

technical field [0001] The invention belongs to the technical field of oral pharmaceutical excipients, and in particular relates to an agent for improving the mouthfeel of a compound polyethylene glycol electrolyte powder oral solution and a preparation method thereof. Background technique [0002] The purpose of preoperative bowel preparation is to assist patients to expel accumulated feces and gas, empty the intestinal tract, reduce intraoperative flatulence, facilitate the exposure of the surgical field of view, and avoid stool contamination of the operating table due to anesthetic relaxation of the anal sphincter during surgery. An ideal bowel preparation drug needs to meet the requirements of clean bowel without feces, reduce irritation and damage to the lesion, avoid intestinal wall edema, reduce pain of patients, and be easy for patients to accept. According to the mechanism of action, the commonly used drugs for intestinal cleansing can be divided into stimulant laxa...

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Problems solved by technology

[0004] At present, the compound preparation of polyethanol electrolyte mainly contains commercially available compound polyethylene glycol electrolyte powder (trade name Hengkang Zhengqing, Jiangxi Hengkang Pharmaceutical Co., Ltd.); Heshuang (trade name Heshuang, produced by Shenzhen Wanhe Pharmaceutical Co., Ltd.), Polyethylene glycol electrolyte powder (trade name Shutaiqing, produced by Shutaishen Beijing Pharmaceutical Co., Ltd.), has a bad taste when used clinically, because the prescription contains sodium chloride and potassium chloride, and the taste will feel salty , polyethylene glycol (4000) has a slightly bitter taste and a special smell, so the compound polyethylene glycol electrolyte powder oral solution will feel bitter and salty when taken, which will give people a poor taste experience and reduce the compliance

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