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Cannabidiol composition and application thereof

A cannabidiol and composition technology, applied in the field of cannabidiol-containing compositions, can solve problems such as potential safety hazards, dangers, etc., and achieve the effects of high stability, consistent pharmacokinetic behavior, and reduction of unpredictable risks

Pending Publication Date: 2019-12-17
YUNNAN HANSU BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] 3) John Merrick, Brian Lane, etc. disclosed the situation of cannabidiol in simulated artificial gastric juice in the article Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid, pointing out that under the experimental conditions, cannabidiol was degraded in 60 minutes 85% and 98% were degraded in 120 minutes, which is very unfavorable. What is even more frightening is that after the degradation of cannabidiol in the artificial gastric juice, the substance transformed into the psychoactive substance tetrahydrocannabinol is Very dangerous, and will inevitably bring huge security risks in practical applications

Method used

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  • Cannabidiol composition and application thereof
  • Cannabidiol composition and application thereof
  • Cannabidiol composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1: Preparation of self-made poloxamer P-HY and determination of performance parameters

[0070] 1. The synthetic route of poloxamer (P-HY):

[0071]

[0072] (1) Condensate propylene oxide onto 1,2-propanediol to obtain a polyoxypropylene chimeric segment; wherein basic 1,2-propanediol is used as an inducer, and the molar ratio of each substance is propylene oxide: 1,2- Propylene glycol: KOH / NaOH=(220-320):1:(2-0.5), the reaction temperature is 90-120°C, the reaction end point (time) varies with different reaction conditions, and the reference standard is the end of the reflux state.

[0073] (2) Under the catalysis of potassium hydroxide (or sodium hydroxide) and EDTA, the ethylene oxide is condensed to the two ends of the polyoxypropylene chimeric segment obtained in step (1), and the molar ratio of the control starting material is ethylene oxide: Polyoxypropylene: potassium hydroxide (or sodium hydroxide): EDTA = (450-650): 1: (0.5-1): (0.05-0.1), the rea...

Embodiment 2

[0107] Embodiment 2: Preparation and performance measurement of cannabidiol composition

[0108] 1. Preparation process of cannabidiol composition

[0109] The cannabidiol composition described in this application can be prepared by the following process:

[0110] a) Physical grinding: Weigh the components of the prescription amount, place them in a suitable size mortar or a special machine for grinding, fully grind until the components described in the prescription are mixed evenly, and then mix the uniformly mixed materials Pulverize by means of physical or jet milling or passing through pharmacopoeia sieve;

[0111] b) Heating and melting: put each component of the prescription amount in a container of suitable size, heat to above 65°C, so that each component of the prescription is in a molten state, and then fully stir evenly at this temperature, and then Cool to room temperature, adopt the method described in a) to pulverize the homogeneous mixture;

[0112] c) Spray d...

Embodiment 3

[0153] Example 3: Biological Activity Evaluation of Cannabidiol Compositions

[0154] According to the method disclosed by GW PHARMA LTD in patent application GB2380129A and Russell Hobart Stebbins in patent application US20160143972A1, two samples for comparative research were prepared to evaluate the technical effect of the cannabidiol composition described in this application, mainly Including stability in gastric juice, bioavailability, plasma protein binding rate and so on.

[0155] Sample to be tested:

[0156] 1) Select the following nine groups of optimized formulas in Example 2 to prepare the composition according to the method described in a) in 1 and carry out subsequent experiments:

[0157] a. Prescription 1: Poloxamer P-HY:CBD:citric acid=100:1:0.01;

[0158] b. Prescription 2: Poloxamer P-HY:CBD:citric acid=50:1:0.01;

[0159] c. Prescription 3: Poloxamer P-HY:CBD:citric acid=100:1:0.02;

[0160] d Prescription 4: Poloxamer P-HY:CBD:citric acid=100:1:0.1;

...

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Abstract

The invention relates to cannabidiol compositions and application thereof. Specifically, the invention relates to a cannabidiol composition containing cannabidiol and a surfactant. The composition cansignificantly improve the water solubility of cannabidiol to make cannabidiol to be better applied in the fields of medicine, daily chemical, food, health products and the like.

Description

technical field [0001] This application relates to the field of chemistry, in particular to a composition containing cannabidiol (CBD), which can significantly improve the water solubility of cannabidiol, making it better used in medicine, daily chemicals, food, health products and other fields. Background technique [0002] Cannabis (scientific name: Cannabis sativa L.) is a plant of the Cannabis family and the genus Cannabis, also known as hemp, hemp, hemp, mountain silk seedlings, jute, and has important agricultural and medicinal values. Marijuana contains a toxic component, tetrahydrocannabinol (THC), which can make people hallucinogenic and addictive. It can be used as a drug and has been banned for a long time. [0003] Cannabis varieties exclusively for industrial use (referred to as "industrial hemp") have a THC content of less than three per thousand in the flowers and leaves during the growth period, and do not have the value of extracting the toxic component THC...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K9/107A61K47/10A61K8/34A61K8/06A61K8/86A61P1/06A61P19/02A61P21/02A61P25/08A61P25/22A61P25/24A61P29/00A61P31/12A61P35/00A61P37/02A61Q19/00A23L33/00
CPCA61K31/05A61K8/347A61K47/10A61K8/86A61K8/068A61K9/1075A61P37/02A61P19/02A61P29/00A61P25/08A61P31/12A61P35/00A61P25/22A61P25/24A61P1/06A61P21/02A61Q19/00A23L33/00A61K2800/21
Inventor 张可谭昕于朝晖柳旭常坦然金倩高伟博
Owner YUNNAN HANSU BIO TECH CO LTD
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