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Oral drug solution formula with function of resisting coccidium and preparation

An anti-coccidian and drug technology, which is applied in the direction of medical preparations, pharmaceutical formulas, anti-infectives, etc. of non-active ingredients, can solve the problems of poor water solubility, achieve good water solubility, improve bioavailability, and facilitate clinical use The effect of using

Inactive Publication Date: 2019-10-01
SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to overcome the deficiency of poor water solubility of samizuril, and provide a combination formula of anticoccidial drugs suitable for drinking water administration, easy to use and stable

Method used

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  • Oral drug solution formula with function of resisting coccidium and preparation
  • Oral drug solution formula with function of resisting coccidium and preparation
  • Oral drug solution formula with function of resisting coccidium and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 Preparation method of anticoccidial drug formula combination

[0013] 1. Drug formulation combination and preparation method

[0014] Table 1 Anticoccidiostat formulation combination and solubility properties

[0015]

[0016] Preparation:

[0017] (1) Mix the drug, organic solvent and solubilizer according to the components in Table 1, stir and heat to 70°C±5°C, until the drug is completely dissolved, let cool to room temperature to obtain the mixed solution 1;

[0018] (2) Take the stabilizer and antioxidant, add it to the mixed liquid 1 cooled to room temperature, and stir until dissolved;

[0019] (3) adding ethanol to 100mL to prepare a pharmaceutical formula combination with anticoccidial properties;

[0020] (4) Filtrate and pack into high-density polyethylene bottles with sealed membranes for oral liquid bottles.

[0021] Water solubility test: Take each formula sample, add water to the drug concentration of 10ppm and 1000ppm respectively, and l...

Embodiment 2

[0023] Embodiment 2 stability test

[0024] The formula combination drug of the coccidiostat solution is samizuril, later called samizuril solution, which is the product in this patent.

[0025] In drug research, in order to monitor the stability of drugs, in view of the changes in their content and related substances under relatively severe conditions, understand the factors that affect their stability, possible explanation pathways and degradation products, and provide support for the production process of pharmaceutical preparations, Packaging, storage conditions and the establishment of degradant analysis methods provide a scientific basis, which is an essential part of new drug research. The general investigation conditions are high temperature, high humidity and light.

[0026] Take the drug formula 2 in Example 1, because the product in this patent is a liquid preparation, so only investigate the stability under 2 conditions of high temperature and light:

[0027] (1) ...

Embodiment 3

[0035] The anticoccidial activity of embodiment 3 samizuril solution

[0036] Chicken coccidiosis is an acute epidemic parasitic disease caused by one or more kinds of coccidiosis. The anticoccidiosis drug preparations used for clinical prevention and treatment are mainly premixes, and samizuril is a new class of veterinary drugs newly developed. Appropriate preparation technology and dosage form can improve the bioavailability of drugs, facilitate clinical use and generate greater social and economic benefits. Considering that samizuril is also a triazine anticoccidial compound, but its physical and chemical properties show that it has better water solubility and other characteristics. Improve bioavailability.

[0037] In this study, the anticoccidial activity of samizuril solution was compared with that of toltrazuril solution (toltrazuril solution). Poisonous, Eimeria tenella, Eimeria turkey glandularis, Eimeria turkey, Eimeria turkey minor all have killing effect. It ma...

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Abstract

The invention relates to an oral drug solution formula with the function of resisting coccidium and preparation, in particular to a compound formula for improving the water solubility of a bioactivitylipophilic drug. According to the specific compound formula, the drug is mixed with one or more of organic solvents, and then mixed with various stabilizers. According to the composition formula, thedrug dosage form is made according to a making method of common drug dosage forms. After the drug dosage form made according to the method is clinically used, after the drug is diluted with water inproportion, the drug is administrated to poultry while the poultry drink water, the solubility and stability of the drug in water are improved, drug absorption is improved, and the bioavailability isimproved.

Description

technical field [0001] The invention relates to a formula combination and preparation of an anticoccidial drug solution, in particular to a method for preparing a samizuril solution, which belongs to the technical field of veterinary drugs. Background technique [0002] Chicken coccidiosis is an acute epidemic parasitic disease caused by one or more coccidiosis. The pathogen is the coccidia of the genus Eimeria in the protozoa. There are 7 recognized species, among which Aimeria tenderis Eimeria tenella, Eimeria necatrix, Eimeria acervulina and Eimeria maxima are highly pathogenic and are The main cause of clinical coccidiosis. [0003] Shamizuril is a new triazine anticoccidial drug independently developed by the Shanghai Veterinary Research Institute of the Chinese Academy of Agricultural Sciences. It has no cross-resistance with diclazuril and toltrazuril, and it has no cross-resistance with Compared with Lee, its anti-coccidial effect is more obvious, without oocysts a...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/53A61K47/10A61K47/18A61K47/26A61P33/02
CPCA61K9/08A61K31/53A61K47/10A61K47/18A61K47/26A61P33/02
Inventor 王霄旸张可煜张丽芳费陈忠薛飞群王米王春梅刘迎春
Owner SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
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