Sol systems, hydrogels and applications for the preparation of pH-sensitive dual network hydrogels

Abstract

The invention belongs to the field of environmental stimulus-responsive drugs, and specifically relates to a sol system for preparing pH-sensitive double network hydrogels, hydrogels and applications thereof, wherein the sol system includes acrylamidated gelatin, oxidized sodium alginate, photoinitiated agent, gentamicin, and mesoporous silica nanoparticles loaded with small molecules of phenamil drug, the sol system rapidly changes from sol to gel under ultraviolet light irradiation, and a pH-sensitive double network hydrogel can be obtained. With excellent physical and chemical properties and good biodescriptive properties, it can effectively slow and control the release of antibacterial drug GS and osteogenic differentiation drug phenamil, prevent early infection of grafts, induce osteogenic differentiation of C2C12 cells, and promote endogenous bone regeneration. Based on the characteristics of the sol system rapidly changing from sol to gel phase under ultraviolet light irradiation, in-situ gelation can be achieved by minimally invasive injection in practical applications, which can meet the requirements of complex orbital bone defect repair. have significant value.

Description

technical field [0001] The invention belongs to the field of environmental stimulus-responsive drugs, and in particular relates to a sol system for preparing pH-sensitive double-network hydrogels, hydrogels and applications thereof. Background technique [0002] Eyes are the most important organ of human senses, and about 80% of the knowledge in the brain is acquired through eyes. The orbital structure is complex. The bony orbital volume is about 30 mL, which accommodates tissues such as eyeballs, muscles, nerves, and blood vessels, and is adjacent to structures such as eyelids, nasal sinuses, brain, and deep facial tissues. As an important part of the orbit, the orbital bone not only has the physiological function of protecting the orbital contents from damage, but also plays an important role in maintaining the beauty of the face. Orbital bone defects can be caused by facial trauma, tumor invasion, congenital deformities or inflammatory diseases, often leading to serious ...

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Problems solved by technology

For example, clinically common bacterial infections on directly implanted or contacted medical devices such as catheters, contact lenses, and artificial joints adversely affect the quality of patient outcomes and lead to high medical costs

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