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Slow release medical composition for treating anxiety disorders and preparation method of slow release medical composition

A technology for sustained-release medicine and composition, applied in the field of medicine, can solve the problems of hindering the development of tandospirone citrate sustained-release pharmaceutical composition, high price of hydroxypropyl methylcellulose, poor patient taking compliance, and the like, Achieve the effects of low preparation cost, low equipment dependence, and easy operation of the production method.

Inactive Publication Date: 2019-06-07
徐维亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Tandospirone citrate is a 5-HT receptor agonist used to treat generalized anxiety disorder and mixed anxiety and depression, but the blood concentration of this drug fluctuates greatly after taking ordinary tablets , patients take poor compliance, short elimination half-life in the body, after a long period of continuous medication, the accumulation of substances in the body
In order to delay the release rate of the drug from the medicament, reduce the absorption rate of the drug into the body, and achieve a better therapeutic effect, at present, there has been clinically a tandospirone citrate sustained-release pharmaceutical composition for treatment, but the prior art The sustained-release effect of the tandospirone citrate sustained-release pharmaceutical composition needs to be further improved, and the hydroxypropyl methylcellulose commonly used as a sustained-release material is expensive, and these defects hinder the slow-release effect of tandospirone citrate. In addition to the further development of drug release compositions, in addition to the long course of taking this drug and the emergence of side effects have brought distress and worry to clinicians and patients

Method used

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  • Slow release medical composition for treating anxiety disorders and preparation method of slow release medical composition

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Embodiment 1

[0028] A slow-release pharmaceutical composition for treating anxiety, made of the following raw materials in parts by weight: 45 parts of tandospirone citrate, 10 parts of 4-aminobutyric acid alginic acid co-modified copolymer, 5 parts of lactose, 3 parts of povidone, 1 part of magnesium stearate, 3 parts of Chinese herbal medicine extract, 5 parts of water; the copolymer is made by allyl β-D-glucopyranoside, sweet glucoside, 1-vinyl- 3-Butylimidazolium chloride is prepared by free radical copolymerization.

[0029] The preparation method of described 4-aminobutyric acid alginic acid co-modified copolymer comprises the steps:

[0030] Preparation of step S1 copolymer: 10 g of allyl β-D-glucopyranoside, 10 g of sweet glucoside, 2 g of 1-vinyl-3-butyl imidazolium chloride salt, and 0.1 g of azobisisobutyronitrile were added to In 60g of dimethyl sulfoxide, stirred and reacted at 70°C under nitrogen atmosphere for 6 hours, then precipitated in hexane, removed the solvent by rot...

Embodiment 2

[0035] A slow-release pharmaceutical composition for treating anxiety, made of the following raw materials in parts by weight: 47 parts of tandospirone citrate, 12 parts of 4-aminobutyric acid alginic acid co-modified copolymer, 7 parts of sucrose, 4 parts of starch, 2 parts of talcum powder, 4 parts of Chinese herbal medicine extract, and 7 parts of water; Imidazolium chloride is prepared by free radical copolymerization.

[0036] The preparation method of described 4-aminobutyric acid alginic acid co-modified copolymer comprises the steps:

[0037] Preparation of step S1 copolymer: 10 g of allyl β-D-glucopyranoside, 10 g of sweet glucoside, 2 g of 1-vinyl-3-butyl imidazolium chloride salt, and 0.15 g of azobisisoheptanonitrile were added to In 75g of N,N-dimethylformamide, stir and react at 73°C under helium gas atmosphere for 6.5 hours, then precipitate in hexane, remove the solvent by rotary evaporation, and place in a vacuum oven at 73°C Dry to constant weight;

[0038...

Embodiment 3

[0042] A slow-release pharmaceutical composition for treating anxiety, which is made of the following raw materials in parts by weight: 50 parts of tandospirone citrate, 13 parts of 4-aminobutyric acid alginic acid co-modified copolymer, 8 parts of manna, 4 parts of microcrystalline cellulose, 3 parts of silicon dioxide, 4 parts of Chinese herbal medicine extract, and 8 parts of water; 3-Butylimidazolium chloride is prepared by free radical copolymerization.

[0043] The preparation method of described 4-aminobutyric acid alginic acid co-modified copolymer comprises the steps:

[0044] Preparation of step S1 copolymer: Add 10g of allyl β-D-glucopyranoside, 10g of sweet glucoside, 2g of 1-vinyl-3-butylimidazolium chloride salt, and 0.2g of azobisisobutyronitrile into In 80g of N-methylpyrrolidone, stir and react at 76°C for 7 hours under a neon gas atmosphere, then precipitate in hexane, remove the solvent by rotary evaporation, and dry in a vacuum oven at 75°C to constant wei...

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Abstract

The invention discloses a slow release medical composition for treating anxiety disorders. The slow release medical composition is characterized by being prepared from the following raw materials in parts by weight: 45-55 parts of tandospirone citrate, 10-15 parts of 4-aminobutyric acid alginic acid co-modified copolymers, 5-10 parts of fillers, 3-5 parts of pore forming agents, 1-3 parts of a lubricant, 3-5 parts of a Chinese herbal medicine extract and 5-10 parts of water, wherein the copolymers are prepared through a co-polymerization reaction on allyl beta-D-glucopyranoside, sweet glucoside and 1-butyl-3-vinylimidazolium chloride through free radicals. The slow release medical composition for treating anxiety disorders disclosed by the invention is good in slow release effects, excellent in the effect of treating the anxiety disorders, high in efficiency, stable in treatment effects, long-lasting to act, convenient in administration, simple in preparation technology, rich in raw material sources, good in medication compliance, small in toxic and side effects and safe to use, and is suitable for clinical use.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a slow-release pharmaceutical composition for treating anxiety and a preparation method thereof. Background technique [0002] With the accelerated pace of life in modern society and the increased pressure from work, study, and life, more and more people suffer from anxiety disorders, mainly manifested in symptoms such as mental stress, poor sleep quality, insomnia, and even depression. It has brought a great impact on the normal life of patients, especially adolescents and middle-aged and elderly patients. [0003] Anxiety is a neurosis mainly characterized by anxiety, mainly manifested as paroxysmal or persistent anxiety, tension, panic and anxiety, accompanied by symptoms such as autonomic disturbance, muscle tension and movement restlessness. Anxiety is a long-term, chronic, recurrent disease with psychosomatic abnormalities. The anxiety symptoms of anxiety disorders are p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/22A61P25/22A61K31/197A61K31/506
Inventor 徐维亮许玲玲王大娟
Owner 徐维亮
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