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Anti-thrombosis and anti-infection titanium alloy implantation instrument with alveolate porous structure

A porous structure, titanium alloy technology, applied in the direction of human tubular structure devices, blood vessels, metal processing equipment, etc., to achieve the effect of low bacterial survival rate, ideal cell activity, and excellent super-hemophobic performance

Active Publication Date: 2019-05-10
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a titanium alloy implant device with anti-thrombosis, anti-infection and honeycomb porous structure in order to reduce the problem of thrombus formation and bacterial infection leading to the failure of medical implant devices

Method used

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  • Anti-thrombosis and anti-infection titanium alloy implantation instrument with alveolate porous structure
  • Anti-thrombosis and anti-infection titanium alloy implantation instrument with alveolate porous structure
  • Anti-thrombosis and anti-infection titanium alloy implantation instrument with alveolate porous structure

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Embodiment 1

[0039] A preparation method of a titanium alloy super-hemophobic anti-thrombosis anti-infection honeycomb porous structure surface based on electronic dynamic regulation in this embodiment includes the following specific steps:

[0040] Step 1, performing optical-grade polishing on the NiTi alloy to obtain a mirror-polished nickel-titanium alloy (P-NiTi) sample, the surface roughness of which is less than 5 angstroms;

[0041] Step 2: Clean the mirror-polished titanium alloy sample described in step 1 with an ultrasonic cleaner, the ultrasonic frequency of which is 40KHZ, submerge the surface of the sample with deionized water and absolute ethanol solution respectively, and clean them respectively at room temperature 5min;

[0042] Step 3, drying the cleaned titanium alloy sample described in step 2 with cold air to obtain a clean titanium alloy sample;

[0043] Step 4, build as figure 1 Double-pulse femtosecond laser processing system;

[0044] Step five, using the femtose...

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Abstract

The invention relates to an anti-thrombosis and anti-infection titanium alloy implantation instrument with an alveolate porous structure and belongs to the technical field of surface modification of metal materials. According to the method, a traditional femtosecond laser shaping mode is replaced with a femtosecond laser dual-pulse mode, correspondingly a local instantaneous electronic state of amaterial is adjusted and controlled, and different micro-nano composite structures can be prepared. Through dynamic regulation and control of electrons, the unique alveolate porous structure is finally processed. According to the structure, the static contact angle between the structure and fresh rabbit blood is 143.4 degrees + / - 2.6 degrees, and the rolling angle is 8.5 degrees + / - 2 degrees. Because a fluorinated material has low surface energy, certain frictional resistance and excellent bactericidal and antithrombotic capability, by conducting fluorination treatment on a NiTi alloy surfaceof the alveolate porous structure, a super blood dispersing surface is obtained, wherein the static contact angle between the super blood dispersing surface and the fresh rabbit blood is 167.3 degrees + / -3.2 degrees, and the rolling angle of the super blood dispersing surface is 1.6 degrees + / - 0.3 degree; meanwhile, the obtained surface also has excellent antibacterial performance. The method isapplicable to the surfaces of titanium alloy materials different in size and shape.

Description

technical field [0001] The invention relates to an anti-thrombosis and anti-infection titanium alloy implantation device with a honeycomb porous structure, in particular to a method for preparing the surface of a titanium alloy super-hemophobic anti-thrombosis and anti-infection honeycomb porous structure based on electronic dynamic regulation, which belongs to metal Material surface modification technology field. Background technique [0002] Biomedical implantable devices have been widely used, such as artificial blood vessels, vascular stents, artificial heart valves, and tissue engineering, which have effectively saved the lives of patients and improved their quality of life. Undoubtedly, the most important feature of an implant is biosafety, the ability to coexist with tissue without causing unacceptable damage to the human body. For medical implanted devices that come into contact with blood, biofilm formation and thrombosis are important complications. When these com...

Claims

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Application Information

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IPC IPC(8): A61F2/06A61F2/24A61F2/82A61L27/06A61L27/28A61L27/50A61L27/54A61L27/56B23K26/06B23K26/0622B23K26/36B23P15/00
Inventor 姜澜马云龙胡洁
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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