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Maimateng extract with high content of Maimatengin C and its manufacturing method

A manufacturing method and technology of extract, which is applied in the field of Maimateng extract and its manufacture, can solve the problems such as non-disclosure, increased intake, etc., and achieve the effects of expanding use, improving reaction speed, and reducing usage

Active Publication Date: 2022-06-21
HOSODA SHC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent Document 1 discloses a method for producing Mateng extract matured at normal temperature to 70°C. It is a method that utilizes the production of Gnetin C caused by the enzymatic reaction during ripening. The content of Gnetin C is less than 15%, in order to obtain the above-mentioned various effects, there is a tendency to increase the intake
And, in said document, for the promotion of the enzymatic reaction in ripening, of course, all do not propose to disclose
In addition, the method of investigating the production state is only a qualitative test using ultraviolet absorption spectroscopy and thin layer chromatography (TLC)

Method used

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  • Maimateng extract with high content of Maimatengin C and its manufacturing method
  • Maimateng extract with high content of Maimatengin C and its manufacturing method
  • Maimateng extract with high content of Maimatengin C and its manufacturing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 18

[0207] Example 18 (Manufacture of extract)

[0208] To 250 mL of water containing 0.2 g of citric acid was added 50 g of the marigold powder prepared in Test Example 1, and the mixture was stirred at 60°C for 2 days, followed by filtration. As a result of HPLC analysis of the filtrate in the same manner as in Test Example 1, GCA was 2609114, GGA was 3138350, TGA was 5747464, 100GCA / TGA was 45.4%, GLA was 187489, and GLA / GCA was 0.072.

[0209] The filtrate was concentrated under reduced pressure, 50 mL of ethanol was added to the obtained concentrate for filtration, and the filtrate was concentrated under reduced pressure to obtain 0.9 g of maize vine extract with a high Gnetin C content in a pale yellowish brown resinous state. The Gnetin C content was 25.2%.

Embodiment 19

[0210] Example 19 (Manufacture of extract)

[0211] 30 g of the marigold powder prepared in Test Example 1 was added to a mixture containing 0.1 g of adipic acid, 1 g of sucrose stearate (HLB15, リョートーシュガーエステル L-1570, manufactured by Mitsubishi Chemical Foods) and propylene glycol monopalmitic acid. Esters (HLB3.8, Rigel PP-100, manufactured by Riken Vitamin Co., Ltd.) 0.2 g in 150 mL of water were stirred at 50° C. for 2 days, and then filtered. As a result of HPLC analysis of the filtrate as in Test Example 1, GCA was 2295142, GGA was 1001508, TGA was 3296650, 100GCA / TGA was 69.6%, GLA was 216987, and GLA / GCA was 0.095.

[0212] The filtrate was concentrated under reduced pressure, 30 mL of acetone was added to the concentrate for filtration, and the filtrate was concentrated under reduced pressure to obtain 0.7 g of Maima Teng extract with a high Gnetin C content as a light yellow-brown resinous substance. The Gnetin C content was 72.8%.

Embodiment 20

[0213] Example 20 (Manufacture of extract)

[0214] After adding 70 g of the M. cane powder prepared in Test Example 1 to a mixed solvent of 300 mL of 0.1w / v% sulfuric acid, 40 mL of propylene glycol, 30 mL of dichloromethane and 0.3 mL of 2-aminoethanol, the mixture was stirred at 60°C for 2 days. , filter with filter cloth. As a result of HPLC analysis of the filtrate in the same manner as in Test Example 1, GCA was 311326, GGA was 443912, TGA was 755238, 100GCA / TGA was 41.2%, GLA was 31935, and GLA / GCA was 0.103.

[0215] The filtrate was extracted twice with 200 mL of ethyl acetate, the ethyl acetate layer was washed with saturated brine, dried with magnesium sulfate, and concentrated under reduced pressure to obtain a pale yellow-brown resinous substance with high Gnetin C content. g. The Gnetin C content was 47.8%.

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Abstract

The present invention provides a method for preventing and / or treating diseases such as metabolic syndrome, diabetes, high blood pressure, gout, cancer, collagen disease, periodontal disease, and cosmetic and / or skin care by reducing intake, serving amount or usage amount. Or protection is useful Gnetin C-rich Gnetin C-rich Mai Mateng extract. A mixed solvent prepared by combining at least one of an emulsifier, a cyclodextrin and an acid with water and / or an organic solvent is used as an extractant to extract the extract from the fruit of Maimaiteng.

Description

technical field [0001] The present invention relates to a Gnetin extract represented by the following formula (1) with a high content of Gnetin (maifengin) C and a method for producing the same. [0002] [Chemical formula 1] [0003] Background technique [0004] A variety of biological effects have been disclosed for the ingredients of hemp vines. Patent Document 1, Patent Document 2, and Non-Patent Document 1 disclose the antioxidant action, antibacterial action, lipase inhibitory action, and amylase inhibitory action of Gnetin C. Non-Patent Document 2 discloses the angiogenesis inhibitory action and antitumor action of Gnetin C. Non-patent document 3 discloses the antitumor effect of GnetinC. Non-Patent Document 4 discloses the apoptosis-inducing effect of Gnetin C in human leukemia cells. Patent Document 3 and Non-Patent Document 5 disclose the immunostimulatory effect of Maima Teng extract. Non-patent document 6 discloses the antibacterial action of Maima Teng e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/13A23L33/105A61K8/9755A61K31/343A61K47/26A61P1/02A61P3/06A61P3/10A61P9/12A61P17/00A61P19/06A61P35/00A61P37/00A61Q19/00
CPCC07D307/80A61P1/02A61P17/00A61P19/06A61P3/04A61P35/00A61P35/02A61P3/06A61P3/10A61P37/00A61P37/06A61P9/12A61K36/17A61K2236/00A61K8/9778A61Q19/08A23L33/105
Inventor 加藤荣信细田真也
Owner HOSODA SHC
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