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A kind of frozen analgesic aerosol and preparation method thereof

An aerosol and analgesic technology, which is applied in the field of frozen analgesic aerosol and its preparation, can solve the problems of high cost, complicated preparation method, large human body irritation, etc., and achieves reduction of phase transition temperature and strong skin penetration. Action, the effect of slowing down blood flow

Active Publication Date: 2021-01-05
ZHONGSHAN TIANTU FINE CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the invention has a good analgesic effect, the preparation method is complicated, the cost is high, the anti-inflammatory effect is general, and the wound is easy to cause infection
[0006] In summary, most of the sprays used for analgesic effect in the prior art have complex components and preparation processes, but they cannot provide long-lasting analgesia, and the drug components in the spray are difficult to be absorbed by the human body, and cannot treat damaged epidermal tissue. It has a good repairing effect, and has antibacterial and anti-inflammatory effects, which is more irritating to the human body

Method used

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  • A kind of frozen analgesic aerosol and preparation method thereof
  • A kind of frozen analgesic aerosol and preparation method thereof
  • A kind of frozen analgesic aerosol and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 A kind of freezing analgesic aerosol

[0031] The frozen analgesic aerosol consists of the following components and their weight percentages: 40.0% of pharmaceutical grade dimethyl ether, 56% of trans-1-fluoro-3,3,3-trifluoropropene, and a skin penetration accelerator 0.5%, analgesic 2.0% and hyaluronic acid 1.5%.

[0032] The skin penetration enhancer is composed of azone, menthol and chondroitin sulfate in a weight ratio of 4:9:3.

[0033] The analgesic is composed of tetrahydropalmatine, the extract of chrysanthemum and glucosamine in a weight ratio of 13:5:12.

[0034] The preparation method of described freezing analgesic aerosol, comprises the following steps:

[0035] S1 Add transdermal enhancer, analgesic and hyaluronic acid into trans-1-fluoro-3,3,3-trifluoropropene, and stir at high speed until the mixed solution forms a micron-sized microemulsion with a particle size of 1 μm solution;

[0036] S2 Pour the micron-sized microemulsion solution o...

Embodiment 2

[0037] Embodiment 2 A kind of frozen analgesic aerosol

[0038]The frozen analgesic aerosol consists of the following components and their weight percentages: 55.0% of 1,3,3,3-tetrafluoropropene, trans-1-fluoro-3,3,3-trifluoropropene 39.0%, transdermal enhancer 1.2%, analgesic 3.0% and skin tissue repair agent 1.8%.

[0039] The skin penetration enhancer is composed of azone, menthol and chondroitin sulfate in a weight ratio of 9:7:2.

[0040] The analgesic is composed of tetrahydropalmatine, the extract of chrysanthemum and glucosamine in a weight ratio of 16:3:7.

[0041] The skin tissue repairing agent is composed of eucommia extract, allantoin and aloin in a weight ratio of 3:1:1.

[0042] The preparation method of described freezing analgesic aerosol, comprises the following steps:

[0043] S1 Add transdermal enhancer, analgesic and skin tissue repair agent to trans-1-fluoro-3,3,3-trifluoropropene, high-speed shearing and stirring until the mixture becomes a micron-siz...

Embodiment 3

[0045] Embodiment 3 A kind of frozen analgesic aerosol

[0046] The frozen analgesic aerosol consists of the following components and their percentages by weight: liquefied petroleum gas 70.0%, trans-1-fluoro-3,3,3-trifluoropropene 22.2%, transdermal accelerator 1.8% %, analgesic 3.5% and aloin 2.5%.

[0047] The skin penetration enhancer is composed of azone, menthol and chondroitin sulfate in a weight ratio of 13:5:1.

[0048] The analgesic is composed of tetrahydropalmatine, the extract of chrysanthemum and glucosamine in a weight ratio of 18:1:4.

[0049] The preparation method of described freezing analgesic aerosol, comprises the following steps:

[0050] S1 Add transdermal enhancer, analgesic and aloin to trans-1-fluoro-3,3,3-trifluoropropene, high-speed shearing and stirring until the mixed solution becomes a micron-sized microemulsion solution with a particle size of 10 μm ;

[0051] S2 Pour the micron-sized microemulsion solution obtained in step S1 into the tank...

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Abstract

The invention belongs to the technical field of aerosol for medical preparations, and particularly relates to frozen analgesic aerosol and a preparation method thereof. The frozen analgesic aerosol isprepared from the following components in percentage by weight: 40.0 to 70.0% of propellant, 22.2 to 56.0% of solvent, 0.5 to 1.8% of transdermal enhancer, 2.0 to 3.5% of analgesic and 1.5 to 2.5% ofskin tissue repair agent. The frozen analgesic aerosol provided by the invention has a good analgesic effect, is fast to absorb by a human body, can achieve long-duration analgesia, is convenient tocarry, and is suitable for using when accidents happen in sports, travelling, living or working, skin damage tissues can be repaired, infection can be prevented, swelling and pain can be relieved, andthe frozen analgesic aerosol can be used for treating sports injuries and acute arthritis.

Description

technical field [0001] The invention belongs to the technical field of aerosols for medical preparations, and in particular relates to a frozen analgesic aerosol and a preparation method thereof. Background technique [0002] Sports injury refers to the anatomical damage or physiological disorder of human tissues or organs caused by mechanical and physical factors during and after exercise. It is generally divided into two types: acute injury and chronic injury. Acute injuries include joint sprains, muscle strains, ligament strains, soft tissue contusions, skin abrasions, joint dislocations, etc. Chronic injuries include arthritis, bursitis, etc. [0003] Among them, acute arthritis refers to the infection caused by suppurative bacteria in the joints, and the clinical manifestations are redness, swelling, heat, pain, dysfunction and joint deformity of the joints. More than 85% of the common pathogens are Staphylococcus aureus. Most of the routes of infection are hematogeno...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K47/06A61K36/53A61P17/02A61P19/02A61P29/00A61P31/00A61K31/4375A61K31/7008
CPCA61K9/12A61K31/4375A61K31/7008A61K36/53A61K47/06A61P17/02A61P19/02A61P29/00A61P31/00A61K2300/00
Inventor 温俊帆卢金霞梁高健张为敬雷涛
Owner ZHONGSHAN TIANTU FINE CHEM CO LTD
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