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UCNPs @ MIL-53 nano composite material and preparation method thereof

A nanocomposite material, MIL-53 technology, applied in the design and preparation of UCNPs@MIL-53 nanocomposite materials, can solve the problems of poor biodistribution, poor pharmacokinetics, adverse side effects, etc., and achieve tissue penetration depth Deep, low biotoxicity, good biocompatibility

Inactive Publication Date: 2019-01-18
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional direct drug delivery will bring more adverse side effects, poor pharmacokinetics and poor biodistribution

Method used

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  • UCNPs @ MIL-53 nano composite material and preparation method thereof
  • UCNPs @ MIL-53 nano composite material and preparation method thereof
  • UCNPs @ MIL-53 nano composite material and preparation method thereof

Examples

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Effect test

preparation example Construction

[0049] A preparation method of said UCNPs@MIL-53 (i.e. MIL-53 coated UCNPs) nanocomposite material, which comprises the following steps:

[0050] Step S1, preparing mother core particles

[0051] Ln(CH 3 COO) 3 (Ln=Y, Yb, Er, molar ratio Y:Yb:Er=78%:20%:2%) was dissolved in water, added oleic acid, and removed moisture in an inert atmosphere, then added 1-octadecene, Cool to room temperature, respectively add 1 mol / L sodium hydroxide and 0.4 mol / L ammonium fluoride methanol mixed solution, stir at room temperature for more than 2 hours, and obtain the mother nucleus solution;

[0052] Step S2, UCNPs nanoparticle crystallization growth

[0053] Dehydrate and remove methanol from the mother nucleus solution in the above step S1 in a high vacuum environment, specifically, vacuum once at room temperature until the solution has no bubbles, then heat up to 120°C to remove water and methanol that has not been removed in a vacuum until Until the solution has no bubbles, the vacuum...

Embodiment 1

[0073] (1) 4mmol of Ln(CH 3 COO) 3 (Ln=Y, Yb, Er where Y:Yb:Er=78%:20%:2%) was dissolved in 20ml of water, added 24ml of oleic acid, heated to 150°C-170°C with argon, kept for 30min, and stopped After heating, add 64ml of 1-octadecene, cool to room temperature, add 10ml of 1mol / L sodium hydroxide and 40ml of 0.4mol / L-ammonium fluoride in methanol, and stir for 2 hours at room temperature.

[0074] (2) Vacuumize the solution in the above (1) step to remove methanol for 0.5h, then raise the temperature to 120°C to remove water and remove methanol for 1h, stop vacuuming, heat up to 280°C±2°C with argon gas, keep it for 75min, and cool to At room temperature, ethanol was added for precipitation.

[0075] (3) Centrifuge the solution of the above (2) step at 11000rpm for 10min to collect the product, and wash it 3 times with a mixed solution of cyclohexane: ethanol = 1:1, and finally the obtained NaYF 4 : Yb, Er dispersed in 20ml chloroform.

[0076] (4) Disperse 150 mg of NaYF4...

Embodiment 2

[0080] (1) 4mmol of Ln(CH 3 COO) 3 (Ln=Y, Yb, Er where Y:Yb:Er=78%:20%:2%) was dissolved in 20ml of water, added 24ml of oleic acid, heated to 150°C-170°C with argon, kept for 30min, and stopped After heating, add 64ml of 1-octadecene, cool to room temperature, add 10ml of 1mol / L sodium hydroxide and 40ml of 0.4mol / L ammonium fluoride in methanol, and stir for 2 hours at room temperature.

[0081] (2) Vacuumize the solution in the above (1) step to remove methanol for 0.5h, then raise the temperature to 120°C to remove water and remove methanol for 1h, stop vacuuming, heat up to 300°C±2°C with argon gas, keep it for 75min, and cool to At room temperature, ethanol was added for precipitation.

[0082] (3) Centrifuge the solution of the above (2) step at 11000rpm for 10min to collect the product, and wash it 3 times with a mixed solution of cyclohexane: ethanol = 1:1, and finally the obtained NaYF 4 : Yb, Er dispersed in 30ml chloroform.

[0083] (4) Disperse 150 mg of NaYF4...

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Abstract

The invention relates to a UCNPs @ MIL-53 nano composite material and preparation method thereof, comprise up-converting fluorescent material UCNPs of parent nucleus and organically coat that parent nucleus UCNPs; Metal skeleton material MIL-53, and that particle size of the parent nucleus UCNPs is 153-0nm, UCNPs@MIL The particle size of 53 nanocomposites is 50-100nm. The UCNPs @ MIL-53 nanocomposites will upconvert the unique fluorescence properties of fluorescent nanomaterials with MIL-53 Combined with excellent drug-loading materials, it is expected to achieve a dual-functional therapeuticsystem integrating biological imaging and drug controlled release.

Description

technical field [0001] The invention belongs to the technical field of composite nanomaterials, and in particular relates to a design and preparation method of a UCNPs@MIL-53 nanocomposite material. Background technique [0002] Cancer is a threat to human health, and millions of people die from cancer every year. The traditional direct drug delivery method will bring more adverse side effects, poor pharmacokinetics and poor biodistribution. New and effective cancer treatments have always been a major challenge in the medical field, and various efforts have been made in the development of nano-drug carriers to achieve controlled drug release, thereby reducing side effects and improving therapeutic efficacy, compared with traditional chemotherapy. Multiple advantages open up new avenues for cancer treatment. Metal-organic framework materials (referred to as MOFs materials) have the advantages of high immobilization rate, controlled release and good biocompatibility, and hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K45/00A61K47/69A61P35/00
CPCA61K45/00A61K47/6949A61K49/0019A61K49/0052A61K49/0054A61P35/00
Inventor 李国玲丛海林于冰贾菲菲申有青
Owner QINGDAO UNIV
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