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Composite aureomycin and chloramphenicol nano emulsion as well as preparation method and application thereof

A technology of compound aureomycin and nanoemulsion, which is applied in the field of medicine, can solve the problems of low antibacterial activity of antibacterial drugs, inaccurate disinfection effect, and toxic and side effects of drugs, so as to reduce drug dosage, improve bioavailability, and good compatibility Effect

Inactive Publication Date: 2018-06-15
XIANYANG VOCATIONAL TECHN COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Common antibacterial drugs have low antibacterial activity, narrow antibacterial range, large dosage, and large environmental pollution, which have certain limitations in clinical application.
Moreover, in the process of use, due to the instability or failure of the drug, it is easy to lead to inaccurate disinfection effect and the generation of toxic and side effects of the drug.

Method used

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  • Composite aureomycin and chloramphenicol nano emulsion as well as preparation method and application thereof
  • Composite aureomycin and chloramphenicol nano emulsion as well as preparation method and application thereof
  • Composite aureomycin and chloramphenicol nano emulsion as well as preparation method and application thereof

Examples

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preparation example Construction

[0025] The preparation method for compound aureomycin and chloramphenicol nanoemulsion of the present invention comprises the following preparation steps:

[0026] (1) Preparation of surfactant phase

[0027] Weigh the surfactant according to the formula ratio, and determine the HLB value of the system. The HLB values ​​of common emulsifiers can be found in some chemical handbooks, such as "Chemical Product Handbook" published by Chemical Press. Since the hydrophilic-lipophilic balance (HLB) value of the surfactant is additive, the HLB value of the surfactant can be obtained by the mass average method. For example, after two surfactants A and B are mixed, the hydrophilic-lipophilic balance HLB of the mixed surfactant AB Values ​​are:

[0028] HLB AB =(W A HLB A +W B HLB B ) / (W A +W B )

[0029] Where: W A , W B - the quality of mixture surfactants A and B;

[0030] HLB A , HLB B —— HLB values ​​of surfactants A and B.

[0031] (2) Preparation of oil phase

[...

Embodiment 1

[0036] A preparation method of compound aureomycin and chloramphenicol nanoemulsion, comprising the following preparation steps:

[0037] Mix 40.0g of hydrogenated castor oil polyoxyethylene ether, 5.0g of isopropyl myristate, 5.0g of snake oil, 1.0g of aureomycin and 1.0g of chloramphenicol. Slowly add distilled water, and stir while adding distilled water. At the beginning, the system has a low viscosity and is in a liquid state. As the amount of water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion, continue to drop Add distilled water and keep stirring. When the system suddenly becomes thinner, it changes from liquid crystal state to liquid state to obtain O / W type yellow transparent compound aureomycin and chloramphenicol nanoemulsion, and the obtained compound aureomycin and chloramphenicol nanoemulsion The weight is 100.0g.

Embodiment 2

[0039] A preparation method of compound aureomycin and chloramphenicol nanoemulsion, comprising the following preparation steps:

[0040]Mix 40.0g of castor oil polyoxyethylene ether, 5.0g of isooctyl palmitate, 5.0g of castor oil, 1.5g of chlortetracycline and 1.5g of chloramphenicol, stir at 22°C to mix them evenly, and slowly Add distilled water and stir while adding distilled water. At the beginning, the system has a low viscosity and is in a liquid state. As the amount of water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion, continue to drop Distilled water and constantly stirring, when the system suddenly becomes thinner, it changes from a liquid crystal state to a liquid state to obtain an O / W type yellow transparent compound aureomycin and chloramphenicol nanoemulsion, and the obtained compound aureomycin and chloramphenicol nanoemulsion The weight is 100.0 g.

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Abstract

The invention provides a composite aureomycin and chloramphenicol nano emulsion as well as a preparation method and application thereof. The nano emulsion comprises the following raw materials: a surfactant, oil, aureomycin, chloramphenicol and water. The nano emulsion is simple in preparation process, free of phase separation or precipitate, and high in storage stability. The composite aureomycinand chloramphenicol nano emulsion provided by the invention is high in antibacterial activity, relatively good in aging stability, thermal storage stability, anti-freezing stability and accelerationstability, is free of conspicuous stimulus response phenomenon, is a wide-spectrum antibiotic, and can be applied to treatment on infections caused by gram-positive bacteria, gram negative bacteria, rickettsia, Chlamydia, mycoplasma, spirochete, actinomycetes and protozoons. The dosage of the medicine can be reduced, drug resistance of bacteria can be reduced or avoided, a slow release property isachieved, the medicine action time is prolonged, the toxic and side effects of the medicine are reduced, the bioavailability and the stability of the medicine are improved, and medicinal effects canbe brought into play sufficiently.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a compound aureomycin and chloramphenicol nanoemulsion and a preparation method and application thereof. Background technique [0002] Antibacterial drugs have the advantages of fast onset of action and low production cost in the treatment of infectious diseases, making them widely used in clinical medicine. However, due to the limitations of traditional dosage forms and the gradual increase of drug resistance, the cost of treatment has increased and the efficacy has declined. Combination drugs are often used clinically to achieve the purpose of expanding antibacterial spectrum, enhancing curative effect, reducing dosage, reducing or avoiding toxic and side effects, and reducing or delaying the emergence of drug-resistant strains. [0003] Chlortetracycline is extracted from Streptomyces culture solution, its hydrochloride is golden yellow or yellow crystal, the color gradually becomes ...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/44A61K31/65A61K31/165A61P31/04A01N37/44A01N37/20A01N25/04A01P1/00
CPCA01N25/04A01N37/20A01N37/44A61K9/1075A61K31/165A61K31/65A61K47/44A61K2300/00Y02A50/30
Inventor 吴旭锦朱小甫张文娟
Owner XIANYANG VOCATIONAL TECHN COLLEGE
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