Implant material for promoting bone wound healing and preparation method thereof

Abstract

The invention discloses an implant material for promoting bone wound healing and a preparation method thereof, which relate to the technical field of a medical material. The bone implant material is composed of a polylactic acid matrix and a medical magnesium alloy frame hanged in the polylactic acid matrix, the medical magnesium alloy frame is obtained by weaving the medical magnesium alloy wiresto form a wave-shape net structure through superposition, the surface of the polylactic acid matrix is modified with a porous hydroxy apatite layer, and the micropores of the hydroxy apatite layer are filled with danshinolic acid B and vancomycin microcapsules. The implant material has good biological compatibility, large specific surface area, and high amount of porosity, is suitable for newbornosteocyte growth, promotes fracture position bridging healing, has strong fixing stability during a fracture bridging healing process, and can prevent secondary fracture; danshinolic acid B and vancomycin with effective concentration can be kept in a medicine system for long-term, so that the continuous inflammation resisting and bridging healing promotion for the fracture can be realized.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an implant material for promoting bone wound healing and a preparation method thereof. Background technique [0002] Internal bone fixation is a routine method in orthopedic trauma surgery, bone defect repair surgery, and plastic surgery. Currently, internal fixation plates and screws are most commonly made of pure titanium or titanium alloy, which have stable fixation effects and superior biocompatibility. It provides a good internal environment for bone tissue healing, but it also has the following problems: (1) The elastic modulus of titanium metal is 8 times that of cortical bone, and it has a stress shielding effect on normal bone tissue, which is easy to cause osteoporosis and relapse Fracture; (2) It cannot be degraded and absorbed. If it is used for a long time, it will block X-rays and affect imaging examinations and chemotherapy for tumor patients. Therefore,...

AI Technical Summary

Problems solved by technology

[0002] Internal bone fixation is a routine method in orthopedic trauma surgery, bone defect repair surgery, and plastic surgery. Currently, internal fixation plates and screws are most commonly made of pure titanium or titanium alloy, which have stable fixation effects and superior biocompatibility. It provides a good internal environment for bone tissue healing, but it also has the following problems: (1) The elastic modulus of titanium metal is 8 times that of cortical bone, and it has a stress shielding effect on normal bone tissue, which is easy to cause osteoporosis and relapse Fracture; (2) It cannot be degraded and absorbed. If it is used for a long time, it will block X-rays and affect imaging examinations and chemotherapy for cancer patients.

However, the mechanical strength of the absorbable internal fixation polymer material is insufficient. If the absorbable polymer plate is fixed on the broken end of the fracture under a large force, as the absorbable plate degrades, the fixation force will weaken, which may lead to secondary fractures.