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Menthol extraction method

An extraction method, menthol technology, applied in chemical instruments and methods, separation/purification of hydroxyl compounds, bulk chemical production, etc., can solve the problems of poor quality, low product purity, low extraction rate, etc., to achieve easy precipitation, Good crushing effect and improved extraction rate

Active Publication Date: 2018-05-08
SICHUAN JINSUIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For above-mentioned existing prior art, the present invention provides a kind of menthol extraction method, to solve the technical problem of low purity, poor quality and low extraction rate of menthol extraction product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Raw material processing: take 500g of fresh and mature mint leaves, wash and dry them, put them into a mortar and grind them, add 50ml of grinding liquid in 5 times during the grinding process, and the grinding liquid includes cellulase with a mass fraction of 1wt%. And the talcum powder that mass fraction is 1wt%; After grinding, add decomposition solution 800ml in the mortar, and adjust solution pH to 6 with hydrochloric acid, decomposition solution includes the cellulase that mass fraction is 3wt%; Stir at room temperature 1min, then Ultrasonic oscillation at 40°C for 20 minutes, with an ultrasonic frequency of 40MHz, to obtain mint pulp;

[0026] (2) Concentration by filtration: filter mint pulp by vacuum filtration; after filtration, put the filtrate into a rotary evaporator and concentrate at 120°C to obtain concentrate A; put the filter residue into a Soxhlet extractor, leaching with 75% ethanol aqueous solution, after the leaching is completed, put the extra...

Embodiment 2

[0030] (1) Raw material processing: take 500g of fresh and mature mint leaves, wash and dry them, put them into a mortar and grind them, add 40ml of grinding liquid in 5 times during the grinding process, and the grinding liquid includes cellulase with a mass fraction of 2wt%. and talcum powder with a mass fraction of 0.5 wt %; after grinding, add 1000 ml of decomposition solution to the mortar, and adjust the pH of the solution to 5 with hydrochloric acid, the decomposition solution includes cellulase with a mass fraction of 2 wt %; stir at room temperature for 2 min, Then ultrasonically oscillate at 45°C for 15 minutes at an ultrasonic frequency of 50 MHz to obtain mint pulp;

[0031] (2) Concentration by filtration: filter mint pulp by vacuum filtration; after filtration, put the filtrate into a rotary evaporator and concentrate at 110°C to obtain concentrate A; put the filter residue into a Soxhlet extractor, and use volume fraction leaching with 80% ethanol aqueous soluti...

Embodiment 3

[0035] (1) Raw material processing: take 500g of fresh and mature mint leaves, wash and dry them, put them into a mortar and grind them, add 45ml of grinding liquid in 5 times during the grinding process, and the grinding liquid includes cellulase with a mass fraction of 2wt%. and talcum powder with a mass fraction of 1 wt%; after grinding, add 1000 ml of decomposition solution to the mortar, and adjust the pH of the solution to 5 with hydrochloric acid, the decomposition solution includes cellulase with a mass fraction of 3 wt%; stir at room temperature for 1 min, then Ultrasonic oscillation at 45°C for 20 minutes at an ultrasonic frequency of 50 MHz to obtain mint pulp;

[0036] (2) Concentration by filtration: filter mint pulp by vacuum filtration; after filtration, put the filtrate into a rotary evaporator and concentrate at 115°C to obtain concentrate A; put the filter residue into a Soxhlet extractor, and use volume fraction leaching with 80% ethanol aqueous solution, af...

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Abstract

The invention discloses a menthol extraction method. The menthol extraction method comprises the following steps: adding a grinding fluid into mint leaves for grinding; then adding a decomposition liquor for decomposition; performing ultrasonic concussion; after that, filtering mint syrup by means of filtration under a reduced pressure; directly concentrating the filtrate; extracting filter residues by means of a Soxhlet extractor; concentrating the extract; after finish of concentration, merging the concentrated solutions; performing freeze drying on the merged concentrated solutions under avacuum condition; crushing the dry product; placing the crushed dry product into a supercritical extractor for supercritical extraction; after finish of extraction, performing fractional distillationon a crude product; and collecting fractions at 160-280 DEG C to obtain menthol. By adoption of the menthol extraction method, the technical problems of low purity, poor quality and low extraction ration of a menthol extraction product can be effectively solved, the menthol extraction ratio can reach 1.65% or above, and the product purity exceeds 92%.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, and in particular relates to a menthol extraction method. Background technique [0002] Mint is a mint plant of the Labiatae family. It is a widely used Chinese medicinal material and one of the three major spices in the world. As a large number of commonly used traditional Chinese medicines, there are as many as 45 kinds of commonly used Chinese patent medicines containing peppermint and its mint oil and menthol recorded in the Pharmacopoeia of the People's Republic of China. Menthol is widely used in medicine and hygiene, daily chemical industry, and food processing. [0003] In the prior art, steam distillation is commonly used to extract menthol, but this method has defects such as poor quality, low product purity and low extraction rate. Contents of the invention [0004] Aiming at the prior art mentioned above, the present invention provides a menthol extraction method to solve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C29/76C07C29/86C07C35/12
CPCC07C29/76C07C29/86C07C35/12Y02P20/54
Inventor 韩业详王洪侯嘉
Owner SICHUAN JINSUIFANG PHARMA
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