Preparation method of antibacterial peptide gynecological gel

Abstract

The invention discloses a preparation method of antibacterial peptide gynecological gel which has the advantages of moderate absorption, lasting curative effect and capability of adjusting the ecological balance of a vagina. The preparation method comprises the following steps: 1) taking honeybees; heating and drying the honeybees; crushing the dried honeybees to obtain honeybee powder; 2) addingthe honeybee powder into a glycerol-acetic acid solution containing arginine; immersing for 12h to 20h and carrying out ultrasonic vibration for 10min to 20min to obtain a mixed solution; 3) filteringthe mixed solution to remove filter residues; heating filtrate at 80 DEG C to 100 DEG C for 40min to 60min; concentrating to obtain a honeybee extracting solution; 4) adding towel gourd juice and aloe powder into the honeybee extracting solution and stirring at 30 DEG C to 50 DEG C for 20min to 40min; then adding an MgCl2 solution; after stirring, carrying out freeze-drying; recovering room temperature in air with the relative humidity of 60 percent to 80 percent to obtain the antibacterial peptide gynecological gel.

Description

technical field [0001] The invention relates to the technical field of gynecology, in particular to a preparation method of an antibacterial peptide gynecological gel. Background technique [0002] Under the action of endocrine hormones in the vagina of healthy women, the epithelial cells proliferate, and the surface cells are rich in glycogen, which is conducive to the growth of Lactobacillus, which accounts for more than 90% of the vagina. The presence of a large number of such lactobacilli inhibits the growth of other pathogenic bacteria and forms a normal ecological balance in the vagina. [0003] When a large number of external pathogens invade and destroy the defense function of the vagina, the microecological balance of the normally parasitic vaginal flora becomes imbalanced, beneficial bacteria such as Lactobacillus in the vagina decrease while other bacteria proliferate in large numbers, and anaerobic bacteria reproduce and produce amines and alkalis at the same tim...

AI Technical Summary

Problems solved by technology

[0004] At present, gynecological gel uses nano-silver ions, which have anti-inflammatory, bactericidal, and antipruritic effects, and can significantly inhibit the growth of pathogenic microorganisms such as Staphylococcus aureus, Escherichia coli, Neisseria gonorrhoeae, Candida albicans, fungi, and yeasts. Antibiotics are mainly used Treatment, but also kills the beneficial flora (lactobacillus, vaginal bifidobacteria), destroying the ecological balance of the vaginal flora

And the manufacturing cost is high, and the contact reaction is strong, so it is not suitable for preventive use

[0005] CN101099815A discloses gynecological antibacterial gel and preparation method thereof, specifically discloses a medicinal composition for antibacterial cleaning of gynecological diseases with reed tea, sulfadiazine silver dry powder, borneol, etc. as characteristic components; the preparation method is to combine carboxymethyl Base cellulose is dissolved in water, and mixed with aloe mesophyll gum, sulfadiazine silver dry powder, and borneol to form a gel. The added sulfadiazine silver dry powder and borneol have a strong bactericidal effect and quickly kill beneficial bacteria. It is suitable for short-term emergency treatment of diseases, but not suitable for prophylaxis with mild absorption and long-lasting effects

Therefore, there is currently a lack of gynecological gels with low cost, smooth absorption, long-lasting curative effect, and regulating vaginal ecological balance.