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A veterinary Fengli granule and its application in chicken necrotizing enteritis

A technology for chicken necrotic enteritis and granules, which is applied in the direction of anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc., can solve problems such as harm to the human body, water and soil pollution, and hidden safety hazards, and achieve The effect of reducing exudation and preventing chicken diarrhea

Active Publication Date: 2020-12-01
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Some people in the industry said that human medicine has not been tested on animals, including dosage and safety tests. If human medicine is used for veterinary use, the dose is not accurate, and there is a great potential safety hazard
In addition, human antibiotics accumulated in animals will be excreted into the environment in the form of prototype or metabolites through feces, polluting water and soil, thus causing the threat of "drug-resistant bacteria" in water and soil, and further harming the human body

Method used

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  • A veterinary Fengli granule and its application in chicken necrotizing enteritis
  • A veterinary Fengli granule and its application in chicken necrotizing enteritis
  • A veterinary Fengli granule and its application in chicken necrotizing enteritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] A kind of extraction process of Polygonum japonica of embodiment 1

[0066] Weigh 20 g of Polygonum japonica powder (Materia japonica: Polygonum japonica = 2:1), place it in a 500ml round bottom flask, use ethanol with a concentration of 55%-75% by volume as the extraction solvent, and the amount of ethanol solution added is 8-12 times as much as the mixture of Polygonum spicosa, soak for 1 hour, and carry out reflux extraction, the extraction time is 60-120 minutes, and the number of extractions is 1-3 times. Set up 7 treatment groups according to different ethanol concentrations, addition amount of ethanol solution, extraction times, and reflux time, see Table 1 for details, the extracts were filtered and combined to obtain the alcohol extract of Polygonum japonica.

[0067] Table 1 The ethanol extraction process of Polygonum japonica

[0068]

[0069] Water was used as the extraction solvent for the control. Weigh 20g of maple leaf powder (Aerial maple: Polygonu...

Embodiment 2

[0138] Embodiment 2 A kind of preparation technology of Fengyao granule

[0139] Mix 1160g Fructus Fructus Fructus and 580g Polygonum capericum, add 10 times the weight of 65% ethanol to reflux and extract twice, each time for 60min, and combine the extracts; centrifuge the combined extracts at 6000r / min for 10min; take the supernatant in Concentrate under reduced pressure at 60°C at 0.08mpa to a relative density of 1.15-1.25 to obtain the extract of Polygonum punctatus, with a yield of 23%, and an average content of total flavonoids in the extract of 30.28±0.45mg / g; vacuum-dried at 80°C into powder to obtain 400 g of Polygonum japonica extract, and the total flavonoid content in the Polygonum japonica extract was 18.67±0.58 mg / g.

[0140] Dextrin and sucrose are mixed according to the weight ratio of 3:2 to obtain auxiliary materials, and the extract of Polygonum japonica and auxiliary materials are mixed according to the weight ratio of 1:1.5, and 85% ethanol is used as a we...

Embodiment 3

[0145] Embodiment 3 A kind of preparation technology of maple Polygonum granule

[0146] Mix 1160g maple japonica and 580g Polygonum capericum, add 10 times the amount of 65% ethanol to reflux for extraction twice, each time for 60min, and combine the extracts; centrifuge the combined extracts at 6000r / min for 10min; take the supernatant at 0.08 Concentrate under reduced pressure at 50°C-70°C under mpa to a relative density of 1.15-1.25 to obtain Polygonum officinalis extract, and determine the average content of total flavonoids in the extract. The experimental results are shown in Table 12. The extract was vacuum-dried at 80°C into powder to obtain the Polygonum japonica extract.

[0147] Table 12 Concentration test result table (n=3)

[0148]

[0149] It can be seen from Table 12 that the total flavonoid content is the highest at 60°C and the lowest at 70°C, there is little difference between 50°C and 60°C, but the difference between 70°C and 60°C is relatively large, b...

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Abstract

The invention discloses a veterinary-use radix daphniphylli calycini and red-knees herb granule and application thereof to chicken necrotic enteritis. The radix daphniphylli calycini and red-knees herb granule is prepared from radix daphniphylli calycini, red-knees herb and auxiliary materials, wherein the active ingredients of the radix daphniphylli calycinum and the red-knees herb in the radix daphniphylli calycini and red-knees herb granule are radix daphniphylli calycini and red-knees herb extracts obtained through performing reduced pressure concentration and vacuum drying on the radix daphniphylli calycini and red-knees herb alcohol extraction liquid; the auxiliary materials are a mixture of dextrin and saccharose. The alcohol extraction process of the radix daphniphylli calycini and red-knees herb is optimized; under the optimum process conditions, 33.01+ / -0.30mg / g of general flavone, 271.31+ / -0.37 mug / g of quercetin and 23.16+ / -0.47 percent of extraction rate can be realized. Through the study, the analgesic effect of the radix daphniphylli calycini and red-knees herb granule on the nervus centralis is a little weaker than the analgesic effect on peripheral nerves; the effusion of early-stage inflammatory tissue fluid can be effectively reduced; the dose-effect relationship is shown, i.e., the inhibition rate is higher when the dose is greater; when the granule is combined with antibiotics, the chicken necrotic enteritis can be effectively prevented and treated.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and in particular relates to a veterinary Fengyao granule and its application in chicken necrotic enteritis. Background technique [0002] Acute and chronic gastroenteritis is a common and frequently-occurring disease. Clinically, abdominal discomfort, abdominal pain, nausea and vomiting, abdominal distension and diarrhea, belching and pantothenic acid, and loss of appetite are the main clinical manifestations. The cause of the disease is often overeating and unclean diet Due to history. It has been found in clinical medicine that the Fengyao preparation composed of Niuerfeng and Cape Polygonum has the functions of regulating qi, invigorating the stomach, dehumidification and stagnation, and is used for acute gastroenteritis and abdominal distension caused by unhealthy middle movement, stagnation of qi and dampness. , abdominal pain and diarrhea and other dyspepsia, clinically achieved good re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/704A61K45/06A61K9/16A61P1/12A61P29/00A61P31/04A61K31/43
CPCA61K9/1652A61K31/43A61K36/185A61K36/704A61K45/06A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 彭新宇蒋琪高彪袁明贵尹烨华徐志宏
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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