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Preparation process of picrorhiza detoxification casual

A technology of Huanglian Jiedu powder and preparation technology, applied in the field of preparation technology of Jiedu powder, can solve the problems of increasing the solid dispersion of Huanglian Jiedu powder, unfavorable feeding of birds, etc., and achieves excellent effects of lowering blood pressure, alleviating bitterness, and reducing immune stress.

Inactive Publication Date: 2017-11-24
杭州科帝生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Existing technologies such as Chinese Invention Authorized Patent Documents, authorized announcement number CN 102058708 B, this invention belongs to the technical field of traditional Chinese medicine for livestock and poultry, and specifically relates to a solid dispersion of Coptidis Rhizome Jiedu Powder, the ingredients of which are: Coptis chinensis, Scutellaria baicalensis, Cortex Phellodendron, Gardenia , polyethylene glycol 6000, poloxamer, glycerin or propylene glycol, the invention adopts ultra-fine pulverization technology and solid dispersion technology to prepare the solid dispersion of Coptis chinensis powder, and selects a suitable carrier, which is conducive to the effective The leaching of the components increases the dispersion and specific surface area of ​​the drug, thereby increasing the solubility and dissolution rate of the solid dispersion of Huanglian Jiedu Powder, improving the bioavailability of the drug, which is beneficial to dispensing, taking and exerting the curative effect. The invention has the functions of clearing heat, detoxifying, It has the effects of purging fire and cooling blood, detoxifying and eliminating pathogens, cooling down and stopping diarrhea, antibacterial and anti-inflammatory, etc. It can be used to treat febrile diseases such as excessive heat in livestock and poultry triple energizers, sores, yellow swelling and poison caused by viruses and bacteria, but the detoxification powder may have a bitter taste , not conducive to poultry ingestion, and there is still room for improvement in improving poultry immunity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation technology of Huanglianjiedu powder comprises the following steps:

[0023] 1) After pulverizing coptis, scutellaria, phellodendron, gardenia, rhubarb, gypenoside, and licorice, add 20% ethanol twice the volume of the Chinese herbal powder to infiltrate the drug, and set aside;

[0024] 2) Heat and melt the carrier PEG6000, and dissolve the poloxamer F68 with an appropriate amount of ethanol;

[0025] 3) Mix the carrier with the infiltrated Chinese medicine, stir at a constant speed under heating conditions, add Chinese herbal medicine additives, active peptides and sweeteners, and cure at -4°C after the solvent evaporates;

[0026] 4) After drying in a vacuum desiccator, crush to 6 mesh, sieve, and pack separately to obtain Coptidis Jiedu Powder;

[0027] Huanglianjiedu Powder is composed of the following ingredients and parts by weight: 20 parts of Coptis chinensis, 18 parts of Scutellaria baicalensis, 22 parts of Cortex Phellodendri, 0.4 parts of gyp...

Embodiment 2

[0032] The preparation technology of Huanglianjiedu powder comprises the following steps:

[0033] 1) After pulverizing coptis, scutellaria, phellodendron, gardenia, rhubarb, gypenoside, and licorice, add 25% ethanol that is 1.5 times the volume of the Chinese herbal powder to infiltrate the drug, and set aside;

[0034] 2) Heat and melt the carrier PEG6000, and dissolve the poloxamer F68 with an appropriate amount of ethanol;

[0035] 3) Mix the carrier with the infiltrated Chinese medicine, stir at a constant speed under heating conditions, add Chinese herbal medicine additives, active peptides and sweeteners, and cure at -4°C after the solvent evaporates;

[0036] 4) After drying in a vacuum desiccator, crush to 5 mesh, sieve, and pack separately to obtain Coptidis Jiedu Powder;

[0037] Huanglian Jiedu powder is composed of the following components and parts by weight: 18 parts of Coptis chinensis, 12 parts of Scutellaria baicalensis, 16 parts of Cortex Phellodendri, 0.2 ...

Embodiment 3

[0042] Weigh Coptis chinensis, Scutellaria baicalensis, Cortex Phellodendron, Gardenia, Rhubarb, Gypenoside, and Glycyrrhizae, add appropriate amount of ethanol to the 200-mesh traditional Chinese medicine powder to infiltrate the drug, then heat and melt the carrier PEG6000, and dissolve the poloxamer F68 with an appropriate amount of ethanol; Mix with the infiltrated medicine, add Chinese herbal medicine additives, sweeteners and active peptides under heating conditions, and stir at a constant speed for a period of time. After the solvent evaporates, quickly place it at -4°C to solidify it; after drying in a vacuum dryer, pulverize , through a No. 5 sieve, and then packed; experimented with 0%, 5%, and 10% doses respectively, and fed pigs of the same species. After 1 month, the results are shown in the table below.

[0043]

Prevalence

weight gain

0% add group

53%

93%

5% add group

37%

121%

10% add group

21%

144%

[...

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PUM

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Abstract

The invention discloses a preparation process of picrorhiza detoxification casual. The preparation process comprises the following steps that coptidis rhizoma, radix scutellariae, cortex phellodendri chinensis, fructus gardeniae, rheum officinale, gypenosides and radix glycyrrhizae are infiltrated and reserved after crushed; a carrier PEG 6000 is heated and melted, and poloxamer F68 is dissolved with an appropriate amount of ethanol; the carrier and infiltrated traditional Chinese medicine are mixed and stirred at a constant rate under the heating condition, Chinese herbal medicine additives, active peptides and sweetening agents are added, and curing is conducted after a solvent is volatilized; and the picrorhiza detoxification casual is obtained through crushing, screening and subpackage after drying in a vacuum drier. The picrorhiza detoxification casual is composed of the following components of the coptidis rhizoma, the radix scutellariae, the cortex phellodendri chinensis, the fructus gardeniae, the rheum officinale, the radix glycyrrhizae, the Chinese herbal medicine additives and the sweetening agents. The picrorhiza detoxification casual has the functions of purging fire, detoxifying, and enhancing immunity, is good in phagostimulating effect without bitterness, is mainly used for healing dampness-heat in triple energizer, sore, yellow swelling and toxin, and is widely applied to horses, cattle, sheep, pigs and poultry.

Description

technical field [0001] The invention relates to a preparation process of Jiedu Powder, in particular to a preparation process of Huanglian Jiedu Powder. Background technique [0002] Huanglian Jiedu Powder is the essence of traditional Chinese medicine, with a classic formula. It is recorded in famous Chinese medicine works such as Wang Tao's "Waitai Secret Yao" and Sun Simiao's "Yinhai Jingwei". , reduce swelling and relieve pain, improve the body's immunity, enhance disease resistance, and promote the rapid recovery of livestock and poultry. It has a good clinical effect on the prevention and treatment of various livestock and poultry diseases. [0003] Coptidis Jiedu Powder is a prescription included in the second part of "The Veterinary Medicine of the People's Republic of China" 2010 edition. It is composed of four traditional Chinese medicines: Coptis chinensis, Scutellaria baicalensis, Cortex Phellodendron, and Gardenia. It has the effect of purging fire and detoxifyi...

Claims

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Application Information

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IPC IPC(8): A61K38/16A61K36/756A61K9/14A61K47/10A61K47/22A61K47/26A61K47/14A61K47/12A61K47/36A61K47/46A61P31/04A61P31/12A61P1/12A61P37/04A61P9/12A61K31/216
CPCA61K9/145A61K9/146A61K9/148A61K31/216A61K36/195A61K36/28A61K36/315A61K36/355A61K36/424A61K36/484A61K36/539A61K36/61A61K36/704A61K36/708A61K36/718A61K36/744A61K36/756A61K38/16A61K2300/00
Inventor 陈剑英
Owner 杭州科帝生物科技有限公司
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