External compound tincture for treating dermatitis and preparation method of such external compound tincture

Abstract

The invention discloses an external compound tincture for treating dermatitis and a preparation method of such external compound tincture. The external compound tincture for treating the dermatitis comprises fluocinolone acetonide, salicylic acid, resorcinol, borneol, clathrate, a co-solvent, an antioxidant, a pH modifier and a solvent. Every 1000 g of tincture is prepared from, by weight, 0.1-10 g of fluocinolone acetonide, 5-100 g of salicylic acid, 20-200 g of resorcinol, 5-50 g of borneol, 1-10 g of clathrate, 2-40 g of co-solvent, 0.30-0.4 g of antioxidant, 2-10 g of pH modifier and 200-800 g of solvent. The external compound tincture for treating the dermatitis and the preparation method of such external compound tincture have the advantages that a reasonable formula and the preparation method are screened to solve the problems that the content of the fluocinolone acetonide is instable and relative substances exceed standards; with the aid of an inclusion technique and by means of an orthogonal experiment, an optimal inclusion rate, an optimal stirring speed and optimal time are determined with the content of the fluocinolone acetonide and the relative substances as indexes so as to generate an explicit and operable preparation process.

Description

technical field [0001] The invention relates to a compound external tincture for treating dermatitis and a preparation method thereof, belonging to the field of chemical preparations. Background technique [0002] The exact cause of neurodermatitis is still unclear, but it is generally believed to be a neuropsychiatric skin disease and related to cerebral cortex dysfunction. It is difficult to treat and easy to relapse. External use of glucocorticoid preparations is an important treatment. Because neurodermatitis often requires long-term treatment, the curative effect of some topical glucocorticoids such as halcinonide solution often decreases after repeated use, and the recurrence rate is high. Fluocinolone containing a halogen-based structure is a potent glucocorticoid, which has anti-inflammatory and antipruritic effects. External application can shrink dermal capillaries and inhibit the proliferation or regeneration of connective tissue cells; it can stabilize intracellu...

AI Technical Summary

Problems solved by technology

[0005] Fluocinonide acetate is a glucocorticoid, and its degradation is mainly caused by the hydrolysis of the 16a, 17-(1-methylethylene) dioxygen bond of fluocinonide acetate. Its stability is affected by high temperature, light, acid and alkali, etc. Larger, the main drug is easy to degrade. Refer to the research results of the commercially available compound fluocinolone acetate by Mr. Kang Jun and Liu Aining from the Liaoyang Drug Control Institute. Seriously affect the safety and effectiveness of medication

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