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Anhydrous toothpaste repairing demineralized enamel and dentin and preparation method thereof

A technology of toothpaste and mass ratio, applied in the field of daily chemical products, can solve the problems of thermodynamic imbalance, unstable paste, chemical reaction, etc., and achieve the effects of uniform and stable paste, reduced pore size, and simple process

Active Publication Date: 2017-03-22
HANGZHOU JIAOJIE ORAL HEALTH CARE PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, some water-soluble phosphates such as disodium hydrogen phosphate and calcium carbonate have thermodynamic imbalance in the water-containing paste, and chemical reactions will occur, causing the paste to be unstable

Method used

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  • Anhydrous toothpaste repairing demineralized enamel and dentin and preparation method thereof
  • Anhydrous toothpaste repairing demineralized enamel and dentin and preparation method thereof
  • Anhydrous toothpaste repairing demineralized enamel and dentin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0046] The method for preparing anhydrous toothpaste includes the following steps:

[0047] S1. Put the above components in a mixer and stir for 40 minutes at 800 rpm;

[0048] S2, vacuum degass into a paste.

[0049] Example toothpaste 2

[0050] This embodiment provides an anhydrous toothpaste 2, which is calculated by mass percentage and consists of the following raw materials:

[0051] Polyethylene glycol 400 6.0 wt%, micron calcium carbonate 8 wt%, hydrated silica 22 wt%, disodium hydrogen phosphate with a mass ratio of 3.41 wt%, carbomer 0.4 wt%, saccharin 0.22 wt%, lemon Zinc acid 0.1 wt%, sodium lauryl sulfate 2.0 wt%, sodium monofluorophosphate 0.76 wt%, flavor 1.2 wt%, and the rest is glycerin; the micron calcium carbonate is calcite crystal form, filtered through a 1200 mesh sieve , The average particle size is 13 µm or less.

[0052] The method for preparing anhydrous toothpaste includes the following steps:

[0053] S1. Put the above components in a mixer and stir for 40 mi...

experiment example 1

[0067] Experimental example 1 In vitro restoration experiment of demineralized tooth enamel

[0068] First, prepare simulated oral saliva (SOF), the specific components are as follows: 137.35 mM NaCl, 4.17 mM NaHCO 3 , 3.01 mM KCl, 7.17 mM K 2 HPO 4 • 3H 2 O, 1.53 mM MgCl 2 • 6H 2 O, 20.00 mM HCl, 0.90 mM CaCl 2 , 0.51 mM Na 2 Adjust the pH to 7.0 with SO4 and Tris.

[0069] Use a low-speed diamond cutting machine (SYJ-160 low-speed diamond cutting machine) to cut ox teeth to prepare enamel slices with a thickness of 2 mm, which are then polished with 200, 400, 1000, 2000 and 4000 mesh silicon carbide water sandpaper to a bright surface Smooth; finally polished with 3M polishing paper (3 microns), and ultrasonically cleaned in deionized water for 3 minutes, and set aside. Use the micro Vickers hardness tester (HV-1000Z, load 500gf, 15 seconds) to measure the micro Vickers hardness of the enamel surface. According to the hardness, select the appropriate enamel sample and randomly di...

experiment example 2

[0072] Experimental Example 2 In vitro restoration experiment of demineralized dentin

[0073] The healthy third molars extracted due to orthodontics (patient informed consent) were collected in the dental hospital, thoroughly cleaned and put into 0.5wt% thymol aqueous solution. Use a low-speed diamond cutting machine (SYJ-160 low-speed diamond cutting machine) to prepare dentin flakes with a thickness of 2mm, and then polish them with 200, 400, 1000, 2000, and 4000 mesh silicon carbide water sandpaper to a bright and smooth surface; finally, use 3M Polishing paper (3 microns) is polished smooth, and ultrasonically cleaned in deionized water for 3 min, and set aside.

[0074] Before use, put each dentin tablet in a 36 wt% phosphoric acid aqueous solution for 2 minutes for demineralization, then rinse with deionized water for 3 minutes, and take out 3 dentin samples as pre-treatment samples for characterization and analysis. Into 4 groups, 3 tablets in each group. The dentin table...

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Abstract

The invention relate to anhydrous toothpaste containing water-soluble phosphate, micron-sized calcium carbonate and fluoride. The mass percent of water-soluble phosphate is larger than 2.0 wt%, the mass percent of micron-sized calcium carbonate is less than 40 wt%, the mass ratio range of water-soluble phosphate and micron-sized calcium carbonate is 1 / 10-5, and the mass concentration of fluorine of fluoride in the toothpaste is less than 8.0 wt%. When the anhydrous toothpaste containing water-soluble phosphate and micron-sized calcium carbonate is used, biological mineralization can be helped to be conducted on demineralized enamel and demineralized dentin slices, the enamel surface is repaired, the bore diameters of dental canaliculi on the dentin dental face is reduced, and even dentinal tubules are blocked. At the same time, fluoride is hydrolyzed to generate fluoride ions, the mineralization process of hydroxyapatite in teeth is promoted, and the repairing function of the toothpaste on enamel and dentin is improved.

Description

Technical field [0001] The invention belongs to the technical field of daily chemical products, and specifically relates to an anhydrous toothpaste capable of mineralizing and repairing demineralized tooth enamel and demineralized dentin and a preparation method thereof. Background technique [0002] Toothpaste has become a necessity in people's daily life. With the improvement of people's living standards, the production of unhealthy diet structure and the intake of high-content sugar threaten people's oral health. High sugar, especially sucrose, remains in the oral cavity and is decomposed into acid, which erodes tooth enamel and dentin exposed on the surface, resulting in demineralization of tooth enamel and dentin, and severely causes tooth decay, tooth loss or tooth sensitivity A series of diseases have seriously affected people's health. Therefore, it is of great significance to develop a toothpaste that can repair demineralized enamel surface and demineralized dentin. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/24A61K8/19A61Q11/00
CPCA61K8/19A61K8/24A61K2800/31A61Q11/00
Inventor 丁观军程吉平吴兴合
Owner HANGZHOU JIAOJIE ORAL HEALTH CARE PRODS
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