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Vaccine diluent and preparing method and application thereof

A technology of diluent and vaccine, applied in the field of vaccine diluent and its preparation, can solve the problems of short antibody maintenance time, long production time, low neutralizing antibody titer, etc.

Inactive Publication Date: 2017-03-01
SICHUAN HUASHEN ANIMAL BIOLOGICAL PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The first object of the present invention is to provide a vaccine diluent, which can solve the problems of low neutralizing antibody titer, long production time, and short antibody maintenance time after vaccine immunization, and can be combined with swine fever vaccine, porcine Pseudorabies vaccine, porcine reproductive and respiratory syndrome vaccine, porcine epidemic diarrhea vaccine, porcine transmissible gastroenteritis vaccine or porcine rotavirus disease vaccine, etc.

Method used

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  • Vaccine diluent and preparing method and application thereof
  • Vaccine diluent and preparing method and application thereof
  • Vaccine diluent and preparing method and application thereof

Examples

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Effect test

Embodiment 1

[0035] The present embodiment provides a kind of vaccine diluent, comprising:

[0036] Dissolve carbomer and levamisole in normal saline to obtain a vaccine dilution with a final concentration of 10 g / L carbomer and 10 g / L levamisole, and adjust the pH to 6.8-7.4 with sodium hydroxide.

[0037] Dilute the vaccine diluent according to a certain volume and then autoclave at 106-121°C for 15 minutes before use.

Embodiment 2

[0039] The present embodiment provides a kind of vaccine diluent, comprising:

[0040] Dissolve carbomer and levamisole in water to obtain a vaccine dilution with a final concentration of 1 g / L carbomer and 10 g / L levamisole, and adjust the pH to 6.8-7.4 with sodium hydroxide.

[0041] Divide the vaccine diluent according to a certain volume and then autoclave at 106-121°C for 30 minutes before use.

Embodiment 3

[0043] The present embodiment provides a kind of vaccine diluent, comprising:

[0044] Each 1L dilution contains: 100mM sodium chloride, 0.5mM potassium chloride, 100mM disodium hydrogen phosphate, 0.1mM potassium dihydrogen phosphate, 1g carbomer, 20g levamisole.

[0045] The preparation method of this vaccine diluent is:

[0046] Dissolve the above substances in water for injection, add sodium hydroxide to adjust the pH to 6.8-7.4, dispense according to a certain volume, and sterilize under high pressure at 106-121°C for 25 minutes before use.

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Abstract

The invention relates to the field of animal biological products, in particular to a vaccine diluent and a preparing method and application thereof. The vaccine diluent is prepared from 0.1-100g / L Carbomer and 0.1-200g / L levamisole; the adopted solvent is any one kind of water, normal saline or phosphate buffer. The vaccine diluent can solve the problems that a neutralizing antibody is low in potency after a vaccine is immunized, long in producing time and short in antibody maintenance time, and can be matched with a livestock and poultry attenuated live vaccine to use, such as a single vaccine or a mixed vaccine of viral vaccines of a swine fever live vaccine, a swine pseudorabies live vaccine, a porcine reproductive and respiratory syndrome live vaccine, a porcine epizootic diarrhea live vaccine, a swine transmissible gastroenteritis live vaccine, a porcine rotavirus disease live vaccine, a fowl pox live vaccine, a new castle disease live vaccine and the like.

Description

technical field [0001] The invention relates to the field of animal biological products, in particular to a vaccine diluent and its preparation method and application. Background technique [0002] Currently, there are no specific therapeutic drugs for common livestock and poultry viral diseases, so vaccination is the best means of prevention and control. Common livestock and poultry virus live vaccines in clinic mainly include live swine fever vaccine, porcine pseudorabies live vaccine, porcine reproductive and respiratory syndrome live vaccine, porcine epidemic diarrhea live vaccine, porcine transmissible gastroenteritis live vaccine, pig Rotavirus disease live vaccine, fowlpox live vaccine, chicken Newcastle disease live vaccine, etc. Except for some special varieties, all live vaccines are produced by freeze-drying process, so they need to be dissolved with vaccine diluent before use. The diluents of various live vaccines mainly include physiological saline and phospha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/32A61K47/22A61K47/02A61K31/429A61K39/245A61K39/12A61K39/215A61K39/225A61K39/15A61K39/17A61K39/275A61P31/20A61P37/04A61P31/14A61P31/22
CPCA61K9/08A61K31/429A61K39/12A61K47/02A61K47/22A61K47/32A61K2039/552C12N2710/12034C12N2710/16734C12N2720/12334C12N2760/18134C12N2770/10034C12N2770/20034A61K2300/00
Inventor 周远成王敖蔡雨函李碧牛婷
Owner SICHUAN HUASHEN ANIMAL BIOLOGICAL PRODS
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