A kind of doxorubicin hydrochloride magnetic nanoparticles and preparation method thereof
A technology of doxorubicin hydrochloride and magnetic nanoparticles, which can be applied to pharmaceutical formulations, organic active ingredients, wave energy or particle radiation treatment materials, etc., can solve problems such as inability to achieve drug delivery, immune exclusion reactions, and high antibody prices, and achieve Increased encapsulation efficiency and drug loading, high drug loading, and stable properties
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Embodiment 1
[0043] Example 1: Optimization of preparation conditions for magnetic drug-loaded nanoparticles
[0044] 1. Investigation of preparation method
[0045] Nanoparticles can be prepared by rotary evaporation, dialysis and rotary evaporation dialysis. The rotary evaporation method is to drop the solution mixed with the drug and nanomaterials into water, and stir at a certain speed to obtain a micellar solution. In the dialysis method, the drug and nano-blocks are directly loaded into the dialysis bag, and the nano-micelle solution is obtained through dialysis. The rotary evaporation dialysis method is to combine the two, the rotary evaporation method is the same as the above, the solution obtained by the rotary evaporation is put into a dialysis bag, and dialyzed in water to obtain a micellar solution. The advantage of the rotary evaporation method is that the reaction is more thorough and purer nanoparticles are obtained.
[0046] The nanoparticles prepared by different method...
Embodiment 2
[0064] Embodiment 2: Preparation of magnetic drug-loaded nanoparticles
[0065] Accurately weigh 20mg of polymer PEG-PLA, dissolve in 4ml dimethylformamide to make solution A; accurately weigh 10mg of doxorubicin hydrochloride (protect from light), dissolve in 4ml dimethylformamide to make solution B; Add 20ul triethylamine to solution B, deionize doxorubicin hydrochloride, 30-40W, ultrasonication for 10min; accurately weigh 10mg of ferric oxide powder, dissolve in 4ml tetrahydrofuran, and ultrasonicate at 200W for 30min to make solution C; Pour the solution into a beaker, and under stirring with a magnetic stirrer, add the deionized B solution dropwise to the A solution at a rate of 20-30 drops / min; Mix the mycin and the nano-block evenly, and the organic solvent volatilizes; slowly add the C solution dropwise to the above-mentioned drug-loaded nano-micelle, and stir evenly with a glass rod; put the prepared magnetic drug-loaded nano-micelle solution into a dialysis bag for d...
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