Bone tissue repair material based on shape memory composite material as well as preparation method and application method of bone tissue repair structure

Abstract

The invention provides a bone tissue repair structure based on a shape memory composite material as well as a preparation method and an application method of the bone tissue repair structure. The preparation method comprises the following steps: (1) diagnosing the size and the shape of a bone injury part, so that a three-dimensional figure is obtained; (2) in accordance with the three-dimensional figure, constructing a preset shape of the shape memory composite material during printing by virtue of a computer; (3) uniformly mixing the following components in parts by weight by virtue of an ultrasonic dispersion method: 90-99 parts of a shape memory polymer, 1-5 parts of a reinforcing material and 1-10 parts of magnetic nanoparticles, so as to obtain a thick liquid, curing and cutting the cured liquid so as to obtain a solid in the form of a block; and (4) sequentially conducting extrusion-molding, three-dimensional printing and ultraviolet irradiation cross-linking on the block-shaped solid, so that the bone tissue repair structure of the shape memory composite material in the preset shape is obtained. The bone tissue repair structure disclosed by the invention has the beneficial effects that bone tissue cells can be induced to grow along the recovery direction of the bone tissue repair structure when the bone tissue repair structure is driven by an external magnetic field, so that repair of bone defect is achieved and the bone cells can grow more tightly.

Description

technical field [0001] The invention relates to a bone tissue repair structure, in particular to a bone tissue repair structure based on a shape memory composite material and a preparation and application method thereof. Background technique [0002] At present, there are two types of cell scaffold materials used in bone tissue engineering, one is synthetic cell scaffold materials, and the other is natural cell scaffold materials. Iyodo et al. transplanted isolated and cultured rabbit iliac bone osteoblasts and hydroxyapatite to a 6 mm defect of autologous ulna. X-ray and histological examination confirmed that the defect had been completely repaired after 13 weeks. Good biocompatibility, but it is difficult to shape and brittle, and its application is greatly limited; Breitbart et al. made a polyglycolic acid non-woven fiber scaffold into a full-thickness bone defect with a diameter of 15 mm, and there were a large number of defects in the defect area after 12 weeks. Osteo...

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Problems solved by technology

[0003] However, with the continuous deepening of research and wide clinical application, it is found that the biomaterials currently used in clinical practice have insufficient biological activity, or unsatisfactory degradation performance, and the materials exist in the body in the state of "foreign matter", which cannot be fused with surrounding tissues Disadvantages such as participation in normal metabolic activities, which affect the clinical use of hard tissue repair materials and the satisfaction of doctors and patients

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