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Novel medical biological material

A new material and biological technology, applied in the field of new medical biological materials, can solve the problems of slow degradation, insufficient bonding strength, poor impact resistance, etc., and achieve moderate curing speed, easy degradation, and improved impact resistance.

Inactive Publication Date: 2016-06-01
FOSHAN MINGQIAN TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing medical glue has the disadvantages of poor impact resistance, slow degradation speed, and insufficient bonding strength

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1 A new medical biological material, prepared from the following raw materials in parts by mass: 188 parts of butyl cyanoacrylate, 0.1 part of hydroquinone, 8 parts of aloe vera nanopowder, 55 parts of soybean protein powder, and 44 parts of chitosan , 5 parts of acetic acid; The preparation method is:

[0012] (1) Take fresh aloe vera, dry it to a moisture content of 15%, and crush it to a particle size of 300-500nm;

[0013] (2) Take each raw material according to the ratio, prepare a chitosan solution with a concentration of 30% in deionized water, then add deionized water 4 times the volume of the chitosan solution, heat to 50°C, add the rest of the components, mix and stir Evenly, adjust the solid content to 25%.

Embodiment 2

[0014] Embodiment 2 A new medical biomaterial, prepared from the following raw materials in parts by mass: 100 parts of butyl cyanoacrylate, 0.051 parts of hydroquinone, 24 parts of aloe vera nanopowder, 20 parts of soybean protein powder, and 10 parts of chitosan 1 part of acetic acid; the preparation method is:

[0015] (1) Take fresh aloe vera, dry it to a moisture content of 20%, and crush it to a particle size of 300-500nm;

[0016] (2) Take each raw material according to the ratio, prepare a chitosan solution with a concentration of 40% in deionized water, then add deionized water three times the volume of the chitosan solution, heat to 60°C, add the rest of the components, mix and stir Evenly, adjust the solid content to 30%.

Embodiment 3

[0017] Example 3 A new medical biological material, prepared from the following raw materials in parts by mass: 200 parts of butyl cyanoacrylate, 0.01 part of hydroquinone, 22 parts of aloe vera nanopowder, 35 parts of soybean protein powder, and 30 parts of chitosan , 3 parts of acetic acid; The preparation method is:

[0018] (1) Take fresh aloe vera, dry it to a moisture content of 10%, and crush it to a particle size of 300-500nm;

[0019] (2) Take each raw material according to the ratio, prepare a chitosan solution with a concentration of 20% in deionized water, then add deionized water twice the volume of the chitosan solution, heat to 40°C, add the rest of the components, mix and stir Evenly, adjust the solid content to 20%.

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PUM

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Abstract

The invention discloses a novel medical biological material, which is prepared from the following raw materials in parts by mass: 80 to 200 parts of n butyl cyanoacrylate, 0.01 to 0.1 part of hydroquinone, 5 to 24 parts of aloe nanometer powder, 20 to 55 parts of soya bean protein powder, 10 to 44 parts of chitosan, and 1 to 5 parts of acetic acid. A preparation method comprises the followings steps of preparing a chitosan solution with the concentration of 20 to 40 percent through deionized water, adding the deionized water with the volume being 2 to 4 times of the chitosan solution, heating to be 40 to 60 DEG C, adding other components, uniformly mixing and stirring, and adjusting the solid content to meet the production requirement. According to the novel medical biological material provided by the invention, the aloe nanometer powder is added to improve the shock resistance of the novel medical biological material, and natural phytoextraction essence and ingredients enables the novel medical biological material to be easier to degrade; with the chitosan component, the bacteria suppression activity of the product is increased. The product provided by the invention is moderate in curing speed, high in adhesive strength, low in heat release during adhesion, good in adhesive thin film toughness, and small in skin irritation, and has high-strength quick adhesive effect on various wounds and surgical incisions, and no scars after curing.

Description

technical field [0001] The invention relates to a new medical biological material, which belongs to the technical field of medical auxiliary products. Background technique [0002] Medical glue is an emerging medical product that replaces sewing needles. The main component of medical glue is a-cyanoacrylate, which has the fastest polymerization speed in biological tissues. Under the action of anions in wound blood and interstitial fluid, medical glue can quickly polymerize and solidify to form a film and inlay tightly with the wound, which can firmly maintain the apposition state of the wound, and the glue film can prevent blood cells and platelets from passing through. Under the joint action of protein, the broken small blood vessels on the wound surface can be effectively stopped bleeding, while the adhesive film isolates the tissue and bacteria, and also has the effect of anti-infection and protection of the wound surface. The ether chain in the polymer also has analgesi...

Claims

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Application Information

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IPC IPC(8): A61L24/10A61L24/08A61L24/00
CPCA61L24/0005A61L24/001A61L24/0015A61L24/10A61L2300/232A61L2300/404
Inventor 黄朝阳
Owner FOSHAN MINGQIAN TECH
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