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Preparation method of nanoparticles for self-controlled temperature magnetic-induction hyperthermia

A magnetic induction hyperthermia and nanoparticle technology, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, wave energy or particle radiation treatment materials, etc., can solve Curie point fluctuations, affect temperature control performance, and chemical stability of nanoparticles gender issues

Active Publication Date: 2016-04-06
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The former is represented by copper-nickel alloy nanoparticles, etc. A.A.Kuznetsov et al. (A.A.Kuznetsov, V.G.Leontiev, V.A.Brukvin, J.Magn.Magn.Mater., 2007, Vo311, 197) prepared a Curie point at 40-60 ℃ Copper-nickel alloy nanoparticles meet the needs of self-temperature control in magnetic hyperthermia, but the nanoparticles have poor chemical stability and are easily converted into oxides directly in the complex human environment, resulting in fluctuations in their Curie point and affecting temperature control performance
The latter is represented by manganese zinc ferrite nanoparticles. Tang et al. (Q.Tang, D. Zhang, X. Cong, M. Wan, L. Jin, Biomaterials, 2008, Vo29, 2673) prepared Curie It is manganese zinc ferrite nanoparticles at 89.56°C. The nanoparticles have a spinel structure and have good chemical stability, but their Curie point does not meet the needs of self-temperature control of magnetic hyperthermia.

Method used

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  • Preparation method of nanoparticles for self-controlled temperature magnetic-induction hyperthermia
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  • Preparation method of nanoparticles for self-controlled temperature magnetic-induction hyperthermia

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Configure 150 mL of 0.4 mol / L NaOH aqueous solution as a precipitating agent.

[0032] (2) Weigh 0.00253mol of CoCl 2 ·6H 2 O, 0.00297 mol of ZnCl 2 ,0.0033mol of CrCl 3 ·6H 2 O and 0.0077mol of FeCl 3 ·6H 2O, dissolved in 80mL of deionized water to obtain a 0.2mol / L metal salt ion solution as a precursor solution; CoCl 2 ·6H 2 O, FeCl 3 ·6H 2 O, CrCl 3 ·6H 2 O and ZnCl 2 The molar ratio is 1.00:3.00:1.30:1.17.

[0033] (3) Add the aqueous NaOH solution obtained in step (1) dropwise into the metal salt ion solution obtained in (2), and stir thoroughly for 30 minutes to obtain a reaction solution.

[0034] (4) Transfer the reaction solution obtained in step (3) to the autoclave and seal it, set the temperature at 250°C, the heating rate at 3°C / min, the magnetic stirring speed at 500r / min, and the pressure at 3.5Mpa. After 2 hours, it was naturally cooled to obtain black particles.

[0035] (5) Open the autoclave, filter the black particles with deioniz...

Embodiment 2

[0038] (1) Configure 150 mL of 0.6 mol / L NaOH aqueous solution as a precipitating agent.

[0039] (2) Weigh 0.00281mol of CoCl 2 ·6H 2 O, 0.00352mol of ZnCl 2 ,0.00408mol of CrCl 3 ·6H 2 O and 0.00958mol of FeCl 3 ·6H 2 O, dissolved in 80mL of deionized water to obtain a 0.25mol / L metal salt ion solution as a precursor solution; CoCl 2 ·6H 2 O, FeCl 3 ·6H 2 O, CrCl 3 ·6H 2 O and ZnCl 2 The molar ratio is 1.00:3.40:1.45:1.25.

[0040] (3) Add the aqueous NaOH solution obtained in step (1) dropwise into the metal salt ion solution obtained in (2), and stir thoroughly for 30 minutes to obtain a reaction solution.

[0041] (4) Transfer the reaction solution obtained in step (3) to the autoclave and seal it, set the temperature to 300°C, the heating rate is 5°C / min, the magnetic stirring speed is 600r / min, and the pressure is 4.0Mpa. After 3 hours, it was naturally cooled to obtain black particles.

[0042] (5) Open the autoclave, filter and wash the black particles ...

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Abstract

The invention discloses a preparation method of nanoparticles for self-controlled temperature magnetic-induction hyperthermia, and belongs to the technical field of magnetic-induction hyperthermia for treating tumors. In a spinel cobalt ferrtte structure, sublattices are divided into tetrahedral sites and octahedral sites, and all Co2+ and one half of Fe3+ are on octahedral sites while the other half of Fe3+ is on the tetrahedral sites; the level of a Curie point is directly determined by the strength of an exchange interaction between the tetrahedral sites and the octahedral sites. According to the method, Cr3+ and Zn2+ are doped into cobalt ferrtte by virtue of a hydrothermal method, so that the number of magnetic ions on the tetrahedral sites and the octahedral sites in the spinel structure is reduced, and subsequently the exchange interaction is weakened; therefore, the Curie point is lowered. By virtue of the spinel structure, the stable chemical properties of the obtained product are guaranteed, and the product, due to the property of low Curie point, is applicable to the self-controlled temperature magnetic-induction hyperthermia. The preparation method is economic and convenient and is easy for popularization.

Description

technical field [0001] The invention belongs to the technical field of tumor magnetic induction hyperthermia, relates to the preparation of nanoparticles for magnetic induction hyperthermia, in particular to a method for preparing nanoparticles for self-temperature-controlling magnetic induction hyperthermia. Background technique [0002] Cancer seriously endangers human health and life, has become the number one killer of human beings, and is the largest public health problem in the world. The main methods currently used for cancer treatment are radiotherapy, chemotherapy and surgery. However, radiotherapy and chemotherapy are usually accompanied by severe side effects, while surgical treatment is mainly suitable for early-stage patients. [0003] Biomedical studies have shown that compared with normal tissue cells, tumor tissue cells have stronger heat sensitivity due to incomplete blood supply. Generally speaking, the temperature for inhibiting the growth of tumor cells...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/14A61P35/00
CPCA61K9/14A61K41/0052
Inventor 张伟左旭东吴承伟
Owner DALIAN UNIV OF TECH
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