Multifunctional nanomicelle for early diagnosis and phototherapy of tumors and application of multifunctional nanomicelle

Abstract

The invention relates to a multifunctional nanomicelle for early diagnosis and phototherapy of tumors. The multifunctional nanomicelle comprises a monolayer functionalized lipid membrane shell, photosensitive molecules and optothermal absorbents, wherein the photosensitive molecules and the optothermal absorbents are embedded into the monolayer functionalized lipid membrane shell. The multifunctional nanomicelle has the advantages that the nanomicelle can be used for multi-modal imaging diagnosis such as early magnetic resonance imaging, photoacoustic imaging or near-infrared fluorescence imaging of cancer; multiple kinds of diagnosis effects can be achieved as long as a patient suffers from one contrast medium administration; since sensitivity is improved, contrast medium injecting dosage is further decreased, and toxic and side effects on the patient can be alleviated; when the tumors are under single-wavelength near-infrared laser radiation, chlorine 6 and Pdots inside the nanomicelle are capable of converting light energy into chemical energy and thermal energy effectively to produce a great number of ROS (reactive oxygen species) oxygen free radicals and overhigh heat at 50-60 DEG C, and the ROS oxygen free radicals and the overhigh heat are used for inducing apoptosis and necrosis of cancer cells, so that a photodynamic and photothermal collaborative therapy function is achieved; the multifunctional nanomicelle not only can be used as a contrast medium for cancer diagnosis, but also can be used as a therapeutic agent for collaborative therapy of the cancer.

Description

(1) Technical field [0001] The invention relates to a Pdots / Ce6lipid-Gd-DOTA multifunctional nano-micelle for early tumor diagnosis and optical therapy and application thereof. (2) Background technology [0002] Hepatocellular carcinoma is one of the common malignant tumors in the digestive system. It has the characteristics of rapid development, high degree of malignancy and poor prognosis, and its incidence is increasing year by year. As a high-incidence malignant tumor, the cancer mortality rate of liver cancer ranks first among all malignant tumors in Fujian Province, about 32 people per 100,000 people died of liver cancer. At present, the treatment of liver cancer is still based on surgical resection, but many patients lose the chance of surgical treatment due to the influence of tumor location, physical tolerance status and degree of liver cirrhosis when they are diagnosed. Although local chemotherapy, interventional therapy, radiofrequency ablation therapy, immunothe...

AI Technical Summary

Problems solved by technology

At present, the treatment of liver cancer is still dominated by surgical resection, but many patients lose the chance of surgical treatment due to the influence of tumor location, physical tolerance status and degree of liver cirrhosis when they are diagnosed

Although local chemotherapy, interventional therapy, radiofrequency ablation therapy, immunotherapy and even liver transplantation have been widely used in the comprehensive treatment of liver cancer and have achieved remarkable curative effects, the long-term survival rate of liver cancer patients is still not ideal (5-year survival The rate is less than 8%, and the 5-year recurrence and metastasis rate is as high as 50-70%)

However, the photosensitizers or photothermal conversion materials currently used have problems such as high toxicity, strong hydrophobicity, slow metabolism in the body, and easy removal by the reticuloendothelial system, which is not conducive to the further clinical application of photodynamic and photothermal therapy.

Images