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Titanium dioxide/strontium and fluorine-containing hydroxyapatite bioactive nano-composite coating as well as preparation method and application thereof

A technology of strontium fluorine hydroxyapatite and nanocomposite coating, which is applied in the direction of coating, surface reaction electrolytic coating, electrolytic coating, etc. Phase impurity and other problems, to achieve the effect of high bonding strength and structural stability, simple composition and low price

Active Publication Date: 2015-06-24
宝鸡卡斯特医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing technologies such as plasma spraying, magnetron sputtering, and sol-gel method can obtain strontium-containing fluorohydroxyapatite on the surface of dense metal substrates, but the bonding strength of the obtained strontium-containing fluorohydroxyapatite coating to the substrate Low, easy to peel off during the planting process; the coating phase is impure, and there are impurities; and it is not in the form of nanometers

Method used

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  • Titanium dioxide/strontium and fluorine-containing hydroxyapatite bioactive nano-composite coating as well as preparation method and application thereof
  • Titanium dioxide/strontium and fluorine-containing hydroxyapatite bioactive nano-composite coating as well as preparation method and application thereof
  • Titanium dioxide/strontium and fluorine-containing hydroxyapatite bioactive nano-composite coating as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1) Preprocessing:

[0033] Polish the titanium disc (size Ф14×2mm) with 180#, 360#, 800#, 1000#, 1500# sandpaper in sequence, and then use 99.5% acetone, 99.7% absolute ethanol, and deionized water to ultrasonically for 20 minutes each;

[0034] 2) Electrolyte preparation:

[0035] Will (CH 3 COO) 2 Ca, (CH 3 COO) 2 Sr, β-C 3 h 7 Na 2 o 6 Dissolve P(β-GP) and NaF in water, mix well, and prepare electrolyte; in electrolyte (CH 3 COO) 2 The concentration of Ca is 0.2mol / L, (CH 3 COO) 2 The concentration of Sr is 0.1mol / L, the concentration of β-GP is 0.02mol / L, and the concentration of NaF is 0.01mol / L;

[0036] 3) Micro-arc oxidation:

[0037]With titanium sheet as the anode and stainless steel as the cathode, a DC pulse power supply is used under the conditions of positive voltage 550 volts, negative voltage 100 volts, frequency 100 Hz, duty cycle 26%, distance between cathode and anode plates 9 cm, and electrolyte temperature 20°C The titanium sheet was s...

Embodiment 2

[0043] 1) Preprocessing:

[0044] Polish the titanium disc (size Ф14×2mm) with 180#, 360#, 800#, 1000#, 1500# sandpaper in sequence, and then use 99.5% acetone, 99.7% absolute ethanol, and deionized water to ultrasonically for 20 minutes each;

[0045] 2) Electrolyte preparation:

[0046] Will (CH 3 COO) 2 Ca, (CH 3 COO) 2 Sr, β-C 3 h 7 Na 2 o 6 Dissolve P(β-GP) and NaF in water, mix well, and prepare electrolyte; in electrolyte (CH 3 COO) 2 The concentration of Ca is 0.15mol / L, (CH 3 COO) 2 The concentration of Sr is 0.15mol / L, the concentration of β-GP is 0.02mol / L, and the concentration of NaF is 0.015mol / L;

[0047] 3) Micro-arc oxidation:

[0048] With titanium sheet as the anode and stainless steel as the cathode, a DC pulse power supply is used under the conditions of positive voltage 550 volts, negative voltage 100 volts, frequency 100 Hz, duty cycle 26%, distance between cathode and anode plates 9 cm, and electrolyte temperature 20°C The micro-arc oxidat...

Embodiment 3

[0050] 1) Preprocessing:

[0051] Polish the titanium disc (size Ф14×2mm) with 180#, 360#, 800#, 1000#, 1500# sandpaper in sequence, and then use 99.5% acetone, 99.7% absolute ethanol, and deionized water to ultrasonically for 20 minutes each;

[0052] 2) Electrolyte preparation:

[0053] Will (CH 3 COO) 2 Ca, (CH 3 COO) 2 Sr, β-C 3 h 7 Na 2 o 6 Dissolve P(β-GP) and NaF in water, mix well, and prepare electrolyte; in electrolyte (CH 3 COO) 2 The concentration of Ca is 0.1mol / L, (CH 3 COO) 2 The concentration of Sr is 0.2mol / L, the concentration of β-GP is 0.02mol / L, and the concentration of NaF is 0.02mol / L;

[0054] 3) Micro-arc oxidation:

[0055] With titanium sheet as the anode and stainless steel as the cathode, a DC pulse power supply is used under the conditions of positive voltage 550 volts, negative voltage 100 volts, frequency 100 Hz, duty cycle 26%, distance between cathode and anode plates 9 cm, and electrolyte temperature 20°C The micro-arc oxidation...

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Abstract

The invention provides a titanium dioxide / strontium and fluorine-containing hydroxyapatite bioactive nano-composite coating as well as a preparation method and an application thereof. The method comprises the following steps: firstly preparing an electrolyte containing calcium ions, strontium ions, fluorine ions and phosphate anions; and then by taking titanium or a titanium alloy as an anode and stainless steel as a cathode, directly preparing the titanium dioxide / strontium and fluorine-containing hydroxyapatite bioactive nano-composite coating on the surface of a titanium or titanium alloy substrate by virtue of a micro-arc oxidation technology. The coating consists of an inner layer combined on the surface of the substrate and a surface layer combined on the surface of the inner layer, wherein the inner layer is a titanium dioxide layer in a form of a nano crystal and the surface layer is a nano-particle strontium and fluorine-containing hydroxyapatite layer. No non-continuous interfaces are available between the coating and the substrate and the coating has high combining strength and structural stable performance; the coating is relatively small in solubility in a simulated body fluid, so that the coating is effectively implanted and used; and the nano-particle strontium and fluorine-containing hydroxyapatite layer in the surface layer can remarkably promote the osteogenic function of the cells to form new bones and inhibit bacterial adhesion and growth.

Description

technical field [0001] The invention belongs to the technical field of bioactivation modification of the surface of medical metal materials, and relates to a titanium dioxide / strontium-containing fluorohydroxyapatite bioactive nanocomposite coating and a preparation method and application thereof. Background technique [0002] Titanium metal has the advantages of good corrosion resistance, strong chemical stability, high specific strength, and excellent biocompatibility, and has important application potential in orthopedics, orthopedics, and stomatology. However, titanium metal is a biologically inert material. After implantation, titanium metal cannot form a chemical combination with the host bone, nor has the ability to promote new bone formation. It is also susceptible to bacterial infection, which seriously affects the implantation effect. Therefore, it needs to be surface bioactivated. modified. [0003] The chemical composition of hydroxyapatite (HA) is similar to th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/26A61L27/32A61L27/54A61L27/50
Inventor 周建宏冯爱玲段旭朝张亚妮王参军张建伟
Owner 宝鸡卡斯特医疗科技有限公司
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