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Palmatine ophthalmic gel and preparation method thereof

A technology of gel and palmatine, applied in the field of medicine, to achieve high affinity, prolong action time, and high cure rate

Inactive Publication Date: 2015-04-08
昆明振华制药厂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no eye drop product with palmatine in the market, only the patents "A Kind of Eye Drops" (authorization number CN100335035C) and "Ophthalmic preparation with palmetine as the main drug" (application number is CN102488688A ) mentions the use of palmatine in ophthalmic preparations

Method used

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  • Palmatine ophthalmic gel and preparation method thereof
  • Palmatine ophthalmic gel and preparation method thereof
  • Palmatine ophthalmic gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Mix and dissolve 0.1g of xanthan gum, 2g of sodium thiosulfate and 3g of disodium edetate with water for injection, add 0.1g of sodium hydroxide and stir well to obtain a matrix solution; weigh another 5g of patinate, add water for injection to dissolve , then add 0.1 g of ethylparaben, 5 g of phenylethyl alcohol and 1 g of sodium chloride and mix well, add to the above matrix solution, add water for injection to 1 L, filter through a microporous membrane, sterilize, dispense and shake well.

Embodiment 2

[0026] Mix 7.5g of chitosan, 7.5g of xylan, 4g of sodium pyrosulfite with water for injection, mix and dissolve, add 20g of triethanolamine and stir well to obtain a matrix solution; weigh another 30g of patinol, add water for injection to dissolve, and then add benzalkonium Mix 0.1 g of ammonium chloride and 100 g of glucose, add to the above matrix solution, add water for injection to 1 L, filter through a microporous membrane, sterilize, dispense and shake well.

Embodiment 3

[0028] Mix and dissolve 7.5g of xylan, 1g of sodium bisulfite and 2g of sodium cyclohexanediaminetetraacetate with water for injection, add 5g of disodium hydrogen phosphate and stir well to obtain a matrix solution; Dissolve in water, then add 0.1 g of benzalkonium bromide and 50 g of mannitol, mix well, add to the above matrix solution, add water for injection to 1 L, filter through a microporous membrane, sterilize, dispense and shake well.

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PUM

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Abstract

The invention relates to palmatine ophthalmic gel and a preparation method thereof. The method comprises the following steps: adding water for injection into a matrix and an antioxidant in a formula dosage, mixing, swelling or dissolving; adding a pH regulator for uniformly stirring, thereby obtaining a matrix liquid; weighing palmatine according to the formula dosage, adding the water for injection for dissolving, adding a preservative and an isoosmotic adjusting agent, uniformly mixing, adding the mixture into the matrix liquid, adding the water for injection to 1L, uniformly shaking, filtering by virtue of a micro-aperture filter membrane, sterilizing, and split charging, thereby obtaining the product. The gel comprises the following components: 0.5-30g of palmatine, 0.1-30g of a matrix, 0.1-20g of a pH regulator, 1-100g of an isoosmotic adjusting agent, 0.01-8g of a preservative and 0.02-5g of an antioxidant. Compared with palmatine liquid type eye drops, the product disclosed by the invention has certain advantages in the dosage form, the administration frequency can be reduced, loss of the medicine in the eyes is avoided, and the effect of the medicine for treating conjunctivitis and keratitis can be obviously improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a palmatine ophthalmic gel and a preparation method thereof. Background technique [0002] The ophthalmic drug delivery system is a drug delivery system with local therapeutic characteristics. It is mainly used clinically for sterilization, anti-inflammation, mydriasis, anesthesia, treatment of glaucoma and reduction of intraocular pressure. Eye drops account for about 70% of ophthalmic preparations, most of which are solution type. Because it is easy to prepare, cheap and easy to use, it is easy to accept. However, because the eyes have very effective protection mechanisms such as tearing and blinking reflex, the liquid medicine dripped into the eye is quickly eliminated from the front area of ​​the cornea, and the biological barrier function of the cornea restricts the medicine from reaching the target tissue in the eye. Therefore, there are certain limitations i...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/4375A61K47/36A61K47/32A61P31/04A61P27/02
Inventor 梅艳李俊
Owner 昆明振华制药厂有限公司
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