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Isoliensinine dropping pill and preparation method thereof

A technology of isoliensinine and alkali dripping pills, which is applied in pill delivery, anti-drugs, pharmaceutical formulations, etc., can solve the problems of patients’ pain, unsuitable oral administration, inconvenience, etc., and achieve improved stability, bioavailability, contact small area effect

Inactive Publication Date: 2015-03-18
宋金春 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, commonly used drugs for cardiovascular and cerebrovascular diseases are often prepared into oral preparations. Generally speaking, oral preparations are absorbed through the mucosa of the gastrointestinal tract. For drugs that are unstable, irritating, and have obvious first-pass effects , not suitable for oral administration; in the past, these drugs were generally administered by injection, and long-term medication would cause great pain and inconvenience to patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 1 g of isoliensinine, 5 g of 75% PEG4000 composite matrix (PEG4000 and PEG6000), 2 g of sodium laurate, heat to 85°C in a water bath and stir, so that isoliensinine and PEG composite matrix and sodium laurate are fully melted Mixing; keep the above-mentioned mixture of isoliensinine and PEG at 75°C, drop it into simethicone oil at 5°C by pill drop method, and condense into a drop pill. The dropping pills were wiped dry with filter paper, dried in a desiccator for 24 hours, and then coated to obtain the dropping pill samples. Each pill weighs about 40mg, and the drug content of each pill is about 5mg.

Embodiment 2

[0019] Weigh 2.5g of isoliensinine, 10g of 75% PEG4000 composite matrix, 2g of sodium laurate, heat to 90°C in a water bath and stir, so that isoliensinine, PEG and sodium laurate are melted and fully mixed; the above-mentioned isoliensinine Keep the mixture of cardiac base and PEG at 80°C, drop it into simethicone oil at 10°C by the pill drop method, and condense into a drop pill. The dropping pills were wiped dry with filter paper, put in a desiccator to dry for 24 hours, and then coated to obtain the dropping pill samples. Each pill weighs about 40mg, and each pill contains about 10mg of medicine.

Embodiment 3

[0021] Weigh 5 g of isoliensinine, 25 g of 75% PEG4000 composite matrix, and 4 g of sodium laurate, heat to 90 ° C in a water bath and stir to make the total alkaloids, PEG, and sodium laurate of lotus seeds melt and fully mix; the above-mentioned lotus seeds The mixture of total alkaloids and PEG in the heart was kept at 80°C, and was dripped into simethicone oil at 10°C by the pill drop method, and condensed into drop pills. The dropping pills were wiped dry with filter paper, put in a desiccator to dry for 24 hours, and then coated to obtain the dropping pill samples. Each pill weighs about 50mg, and the drug content of each pill is about 15mg.

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese pharmacology. The invention discloses an isoliensinine dropping pill which is prepared by using a water-soluble matrix (preferably polyethylene glycol) as a carrier. The mass ratio of the isoliensinine to polyethylene glycol in the pill is 1:1-6. The isoliensinine dropping pill of the present invention is prepared by weighing the matrix and the main drug according to the ratio, mixing, stirring, co-melting, and dropping pill preparation. The isoliensinine dropping pill of the present invention can be absorbed rapidly through sublingual mucous membrane, and thus the bioavailability is improved.

Description

technical field [0001] The invention relates to a medicinal dosage form of isoliensinine, in particular to a preparation method of a dripping pill preparation of isoliensinine. [0002] Background technique [0003] The lotus seed heart is Nelumbo nucifera Gaertn, a plant of the Nymphaeaceae family. The green germ of mature seeds has the effect of "clearing heart-fire and consolidating essence and blood". It is recorded in Chinese Pharmacopoeia as a traditional Chinese medicine. Isoliensinine is a bisbenzyl isoquinoline alkaloid extracted from the lotus seed heart, which has the functions of lowering blood pressure, antiarrhythmia, antihyperlipidemia, antilipid peroxidation, protecting cerebral ischemia, etc. Cardiac and cerebrovascular system activity, and pharmacological effects such as inhibiting platelet aggregation, anti-oxidation and scavenging active free radicals, relaxing smooth muscle, strengthening the heart, anti-cancer, improving acute lung injury and pulmonar...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4725A61K47/34A61P9/12A61P9/06A61P3/06A61P9/10A61P7/02A61P39/06A61P11/00A61P3/10A61P35/00
Inventor 宋金春宋杨一嫣彭燕
Owner 宋金春
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